Classification of Canine Urinary Bladder Urothelial Tumours Based on the World Health Organization/International Society of Urological Pathology Consensus Classification

Patrick, Daniel J.; Fitzgerald, Scott D.; Sesterhenn, Isabell A.; Davis, Charles J.; Kiupel, Matti

doi:10.1016/j.jcpa.2006.07.002

Cited by 61 publications

(40 citation statements)

References 10 publications

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“…Although neoplastic cells may be present in the urine of 30% of dogs with TCC, 4 neoplastic cells often are indistinguishable from reactive epithelial cells associated with inflammation. 4,21 Methods for obtaining tissue for histopathologic diagnosis include cystotomy, cystoscopy (see Figure 29-2), and traumatic catheterization. A bladder or urethral mass may raise suspicion for TCC, but as discussed previously, other conditions can cause bladder and urethral masses (see Figures 29-2 and 29-3 and Table 29-2).…”

Section: Diagnosis and Differential Diagnosesmentioning

confidence: 99%

Tumors of the Urinary System

Knapp¹,

McMillan²

2013

Withrow and MacEwen's Small Animal Clinical Oncology

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Section: Diagnosis and Differential Diagnosesmentioning

confidence: 99%

Tumors of the Urinary System

Knapp¹,

McMillan²

2013

Withrow and MacEwen's Small Animal Clinical Oncology

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“…Primary lung cancer is the leading cause of cancer-related mortality worldwide and has a poor prognosis compared with other types of cancer (1). Approximately 80% of all lung cancer cases are histologically classified as non-small cell lung cancer (NSCLC) (2).…”

Section: Introductionmentioning

confidence: 99%

Clinical significance of the induction of macrophage differentiation by the costimulatory molecule B7-H3 in human non-small cell lung cancer

et al. 2013

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B7-H3, a member of the B7 family of molecules, is expressed in certain types of human cancer and is important in tumor development and progression. Although several studies have reported that the expression of B7-H3 is correlated with poor outcomes in patients with cancer, its exact role in cancer remains unknown. In the present study, the expression levels of B7-H3 in the pathological specimens of 105 patients treated for non-small cell lung cancer (NSCLC) were examined by immunohistochemistry. A high expression level of B7-H3 was observed in 46.9% of the 105 NSCLC tissue specimens. These patients demonstrated a more advanced tumor grade and a shorter survival time. In addition, we also examined the levels of tumor-associated macrophages (TAMs) in NSCLC tissues and observed that the levels were positively correlated with the expression of B7-H3, and that higher levels of macrophages were associated with lower levels of infiltrating T cells and a shorter survival time. These results demonstrated that TAMs are important in the evasion of tumor immune surveillance in NSCLC. Furthermore, through knockdown of B7-H3 by RNA interference, we observed that soluble B7-H3 was capable of inducing macrophages to express higher levels of macrophage mannose receptor (MMR) and lower levels of human leukocyte antigen (HLA)-DR, as well as higher levels of interleukin-10 (IL-10) and lower levels of IL-1β in vitro. These observations are characteristic of an anti-inflammatory/reparatory (alternative/M2) phenotype. Therefore, our data suggests that B7-H3 proteins are involved in the progression of NSCLC by inducing the development of monocytes into anti-inflammatory cells.

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“…cauliflower-like proliferation bulging into the lumen of the urinary bladder can be noticed. Other neoplasms which may occur in the urinary bladder are: adenocarcinoma, poorly differentiated cell carcinoma, papilloma, fibroma, and leiomyoma (Schwarz et al 1989, Maxie et al 1993, Sapierzyński 2000, Patrick et al 2006. …”

Section: Urinary Bladdermentioning

confidence: 99%