Classification of gastric carcinoma using the Goseki system provides prognostic information additional to TNM staging

Songun, Ilfet; Velde, Cornelis J.H. van de; Arends, Jan Willem; Blok, P.; Grond, A. J. K.; Offerhaus, G. Johan A.; Hermans, J.; Krieken, J.H.J.M. van

doi:10.1002/(sici)1097-0142(19990515)85:10<2114::aid-cncr3>3.0.co;2-u

Cited by 39 publications

(36 citation statements)

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“…According to Goseki classification, it should be noted that somewhat inconsistent results were shown by the two independent studies finding significant differences in survival of patients with gastric carcinoma Songun et al, 1999). The 5-year survival rates or median survival times varied according to Goseki grades in different ways in the two studies: Martin et al (1994) observed longer survival in Goseki grade III when compared with grade IV patients, while the contrary was found by Songun et al (1999).…”

Section: Discussionmentioning

confidence: 90%

“…It is based on two cancer features: tubular differentiation and the degree of mucus production by the tumour cells. Previous reports have suggested that mucus production could be of greater importance than tubular differentiation in the assessment of prognosis (Goseki et al, 1992;Martin et al, 1994;Songun et al, 1999). Mucins are heavily glycosylated glycoproteins that are the main components of the mucous viscous gel covering the surface of epithelial tissues.…”

Section: Discussionmentioning

confidence: 99%

“…The prognostic value of Goseki classification has been evaluated in only a few studies in patients with gastric cancer with contradictory results Dixon et al, 1994;Guglielmi et al, 1997;Roy et al, 1998;Songun et al, 1999), although some authors have suggested selecting patients for adjuvant therapy after curative resection of cancer according to the Goseki classification .…”

Section: Discussionmentioning

confidence: 99%

“…According to the Goseki classification, four grades of histologic features were defined: group I) -well-differentiated tubules, poor intracellular mucus; group II) -well-differentiated tubules, rich intracellular mucus; group III) -poorly differentiated tubules, poor intracellular mucus; group IV) -poorly differentiated tubules, rich intracellular mucus. The high reliability (inter-and intra-observer agreement) of this classification system has been demonstrated by other research groups Songun et al, 1999). Two recent studies found that the Goseki histological classification was predictive of survival in patients with gastric cancer Songun et al, 1999), although two other studies did not (Guglielmi et al, 1997;Roy et al, 1998), and thus the prognostic value of the system remains controversial.…”

mentioning

confidence: 86%

“…The high reliability (inter-and intra-observer agreement) of this classification system has been demonstrated by other research groups Songun et al, 1999). Two recent studies found that the Goseki histological classification was predictive of survival in patients with gastric cancer Songun et al, 1999), although two other studies did not (Guglielmi et al, 1997;Roy et al, 1998), and thus the prognostic value of the system remains controversial. To our knowledge, the Goseki histologic classification has so far not been applied in patients with cardia adenocarcinoma.…”

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confidence: 88%

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Prognostic value of Goseki histological classification in adenocarcinoma of the cardia

et al. 2003

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Various histologic classification systems have been proposed as prognostic factors for gastric cancer. We assessed the prognostic value of Goseki classification as well as the TNM staging system, histological tumour grading, Lauren, WHO, Goseki and Siewert classifications in 100 patients with cardia carcinoma undergoing curative surgery. Two patients were lost at follow-up. The median time of follow-up in the remaining patients was 32.9 months after surgery (range: 0.1 -142.1 months). No differences in survival rates were observed according to tumour grading, Lauren or WHO histologic or Siewert topographical classification. No differences were found according to Goseki classes, when considering either the mucin content of the carcinoma (types I and III vs II and IV) or the differentiation grade (types I and II vs III and IV). Multivariate analysis showed that the only lymph node positivity was a significant predictor of survival: 7.2% of patients with, but 41.5% of those without nodal involvement were alive after five years (P ¼ 0.0001). In conclusion, we found no prognostic role for Goseki or the traditional histological indexes, while the TNM staging system and particularly lymph node positivity were the main predictors of survival in patients with cardia adenocarcinoma.

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Section: Discussionmentioning

confidence: 90%

Section: Discussionmentioning

confidence: 99%