The small sample universal hypothesis testing problem is investigated in this paper, in which the number of samples is smaller than the number of possible outcomes . The goal of this paper is to find an appropriate criterion to analyze statistical tests in this setting. A suitable model for analysis is the high-dimensional model in which both and increase to infinity, and . A new performance criterion based on large deviations analysis is proposed and it generalizes the classical error exponent applicable for large sample problems (in which ). This generalized error exponent criterion provides insights that are not available from asymptotic consistency or central limit theorem analysis. The following results are established for the uniform null distribution: 1) The best achievable probability of error decays as for some . 2) A class of tests based on separable statistics, including the coincidence-based test, attains the optimal generalized error exponents. 3) Pearson's chi-square test has a zero generalized error exponent and thus its probability of error is asymptotically larger than the optimal test. Index Terms-Bahadur efficiency, Chernoff efficiency, error exponent, hypothesis testing, large alphabet, large deviations, separable statistic, small sample.