The purpose of this study was to develop a wearable waist exoskeleton to provide back support for industrial workers during repetitive lifting tasks and to assess reductions in back muscular activity. The ergonomic mechanical structure is convenient to employ in different applications. The exoskeleton attaches to the wearer’s body with 4 straps, takes only 30 s to put the exoskeleton on without additional help, weighs just 5 kg and is easy to carry. The mechanical clutch can assist the wearer as needed. Inertia Measurement Unit (IMU) was used to detect wearers’ motion intention. Ten subjects participated in the trial. Lower back muscle integrated electromyography (IEMG) of the left and right lumbar erector spinae (LES), thoracic erector spinae (TES), latissimus dorsi (LD) were compared in symmetrical lifting for six different objects (0, 5, 10, 15, 20, 25 kg) under two conditions of with and without the exoskeleton. The exoskeleton significantly reduced the back muscular activity during repetitive lifting tasks. The average integrated electromyography reductions were 34.0%, 33.9% and 24.1% for LES, TES and LD respectively. The exoskeleton can reduce burden and the incidence of strain on lumbar muscles during long-term lifting work.