The ocean thermal energy conversion (OTEC) systems, as renewable energy-based power plants, have the potential to play a significant role in meeting future electricity demands due to the vast expanse of the world's oceans. These systems employ the temperature difference between surface ocean waters and deep ocean waters to drive a thermodynamic cycle and produce electricity. The temperature of deep ocean waters, approximately 1000 m below the surface, is approximately 4 °C, while surface ocean temperatures typically range between 20 and 30 °C. The generated power of OTEC systems is dependent on these temperature differences and may vary with changes in surface ocean temperatures. In this study, the main focus is to find the impact of temperature variation on the failure rates of OTEC system components and the generated power output of these plants. The findings indicate that as the demand for the power system increases, its reliability decreases. In order to improve the reliability of the power system, the integration of a new generation unit, such as the close cycle OTEC power plant under investigation, could be necessary. The findings also indicate the importance of considering temperature variation in the evaluation of the reliability of such types of power plants based on renewable energy.