Classification of Spectroscopically Encoded Resins by Raman Mapping and Infrared Hyperspectral Imaging

Fenniri, Hicham; Terreau, Owen; Chun, Sangki; Oh, Sung Joon; Finney, William F.; Morris, Michael D.

doi:10.1021/cc050128i

Cited by 31 publications

(31 citation statements)

References 119 publications

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“…One of the applications envisioned for Raman flow cytometry involves the preparation and screening of combinatorial libraries prepared on encoded polymeric beads(15,16). For this reason we chose the Union Biometrica COPAS large particle sorter as a platform for the implementation of Raman detection capabilities.…”

Section: Resultsmentioning

confidence: 99%

Spectral measurements of large particles by flow cytometry

et al. 2009

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Flow cytometers designed to analyze large particles are enabling new applications in biology and chemistry. Similarly, flow spectroscopy approaches are extending the capabilities of the flow cytometry platform. Here, we report on the adaptation of a commercial large particle analyzer to measure fluorescence and Raman spectra of individual particles at high speeds. We modified a Union Biometrica COPAS Plus instrument to allow red excitation and optical fiber-based light collection and spectral analysis using a spectrograph and CCD array detector. These modifications did not compromise the ability of the instrument to resolve different sized particles based on their extinction and time of flight signals. The modified instrument has the sensitivity and spectral resolution to measure the fluorescence and Raman signals from individual particles with signal integration times of 10 usec. The high speed spectral analysis of individual particles in flow will enable new applications in biological and chemical analyses. ' 2009International Society for Advancement of Cytometry

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Section: Resultsmentioning

confidence: 99%

Spectral measurements of large particles by flow cytometry

et al. 2009

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“…700 BCRs available thus far 87 —can then be used as a data point for pattern recognition, increasing the accuracy of symptom specific and disease-specific response for the e-nose device. 87–93 …”

Section: Technological Advances and Applications: Barcoded Resin Tmentioning

confidence: 99%

Biomimetic cross-reactive sensor arrays: prospects in biodiagnostics

Fitzgerald

Fenniri

2016

RSC Adv.

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Biomimetic cross-reactive sensor arrays have been used to detect and analyze a wide variety of vapour and liquid components in applications such as food science, public health and safety, and diagnostics. As technology has advanced over the past three decades, these systems have become selective, sensitive, and affordable. Currently, the need for non-invasive and accurate devices for early disease diagnosis remains a challenge. This review provides an overview of the various types of Biomimetic cross-reactive sensor arrays (also referred to as electronic noses and tongues in the literature), their current use and future directions, and an outlook for future technological development.

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“…Fourier transform infrared (FTIR) imaging in particular has been applied as a high throughput technique for the characterization and reaction monitoring of bead-supported organic materials,3, 4 heterogeneous catalysts,3, 5, 6 and pharmaceuticals 7. FTIR imaging employs a focal plane array (FPA) detector, which provides two-dimensional spatial resolution that is utilized as a means to acquire spectra from multiple samples simultaneously.…”

Section: Introductionmentioning

confidence: 99%

Parallel Spectroscopic Method for Examining Dynamic Phenomena on the Millisecond Time Scale

2009

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An infrared spectroscopic technique based on planar array infrared (PAIR) spectroscopy has been developed that allows the acquisition of spectra from multiple samples simultaneously. Using this technique, it is possible to acquire spectra over a spectral range of 950–1900cm−1 with a temporal resolution of 2.2ms. The performance of this system was demonstrated by determining the shear-induced orientational response of several low molecular weight liquid crystals. Five different liquid crystals were examined in combination with five different alignment layers, and both primary and secondary screens were demonstrated. Implementation of this high throughput PAIR technique resulted in a reduction in acquisition time as compared to both step-scan and ultra-rapid-scanning FTIR spectroscopy.

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Classification of Spectroscopically Encoded Resins by Raman Mapping and Infrared Hyperspectral Imaging

Cited by 31 publications

References 119 publications

Spectral measurements of large particles by flow cytometry

Spectral measurements of large particles by flow cytometry

Biomimetic cross-reactive sensor arrays: prospects in biodiagnostics

Parallel Spectroscopic Method for Examining Dynamic Phenomena on the Millisecond Time Scale

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