Classification of Subtypes of Ischemic Stroke

Adams, Harold P.; Biller, José

doi:10.1161/strokeaha.114.007773

Cited by 92 publications

(39 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Stroke severity was quantified using the National Institutes of Health Stroke Scale (NIHSS) at the admission and 7 th day of hospitalization. Acute ischemic stroke was classified according to the TOAST system, that differentiates large artery arteriosclerosis, small artery occlusion, cardioembolism, other demonstrated cause, and cryptogenic stroke [14]. …”

Section: Methodsmentioning

confidence: 99%

Predictive value of serum transthyretin for outcome in acute ischemic stroke

et al. 2017

View full text Add to dashboard Cite

IntroductionThe impact of choroid plexus with its blood–cerebrospinal fluid barrier in the ischemic stroke pathology is poorly explored. Transthyretin (TTR) is a protein synthesized in liver and just in choroid plexus.ObjectivesThe current study was designed to assess the prognostic value of serum TTR for functional outcome (at the time of hospital discharge) and long-term (one-year) overall mortality in ischemic stroke patients.Patients and methodsWe conducted a prospective observational study. Patients (n = 81) with acute (< 24 hours of symptoms onset) ischemic stroke consecutively admitted to Stroke Unit were included. An unfavorable outcome was defined as a modified Rankin Scale (mRS) score ≥ 3. The relationships between serum TTR levels and clinical outcome were analyzed using multivariate analysis. One-year mortality was analyzed by Kaplan–Meier survival curves stratified by mean value of TTR.ResultsCompared with patients with mRS <3, patients with an unfavorable outcome at hospital discharge had significantly lower TTR levels on admission (P < 0.0001). In non-survivals serum TTR levels were significantly lower compared with patients who survive one year of observation (P = 0.009). Using multivariate analysis, transthyretin emerged as an independent predictor for unfavorable outcome at the day of hospital discharge (adjusted odds ratio = 0.96; 95% CI: 0.9–0.99, P <0.05). A one-year mortality of patients with the lower TTR levels was significantly higher than in patients with TTR levels above mean value (P = 0.02).ConclusionsSerum level of TTR at admission was a predictor of functional outcome after ischemic stroke and was also associated with one-year mortality in stroke survivals.

show abstract

Section: Methodsmentioning

confidence: 99%

Predictive value of serum transthyretin for outcome in acute ischemic stroke

et al. 2017

View full text Add to dashboard Cite

show abstract

“…18 A modified version of CCI (MCCI), excluding 2 items (cerebrovascular disease and hemiplegia), 2 was computed for each patient. Further information on comorbidities not included in the original database was collected through review of medical records.…”

Section: Methodsmentioning

confidence: 99%

Validity of the Modified Charlson Comorbidity Index as Predictor of Short-term Outcome in Older Stroke Patients

Denti

Artoni

Casella

et al. 2015

Journal of Stroke and Cerebrovascular Diseases

View full text Add to dashboard Cite

“…Carotid artery occlusion was assessed by ultrasound and, if necessary, by contrast‐enhanced MR angiography, and graded according to NASCET criteria . In addition, stroke etiology was rated on DWI according to the TOAST classification . The study was approved by the local ethics committee.…”

Section: Methodsmentioning

confidence: 99%