Classification of the degenerative grade of lesions of supraspinatus rotator cuff tendons by FT-Raman spectroscopy

Fogazza, Bianca Palma; Carvalho, Carolina da Silva; Penteado, Sergio Godoy; Meneses, Cláudio Santos; Martin, Aírton Abrahão; Martinho, Herculano da Silva

doi:10.1117/12.702203

Cited by 1 publication

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The goal of the work presented here was to determine whether Raman spectroscopy could be used as this auxiliary aid, enabling real-time diagnosis of the degenerative state of rotator cuff supraspinatus tendons. In a pilot study, 20 our group previously showed that Raman spectroscopy enabled the classification of normal and degenerative tendon tissues.…”

Section: Introductionmentioning

confidence: 99%

Diagnosis of degenerative lesions of supraspinatus rotator cuff tendons by Fourier transform-Raman spectroscopy

et al. 2008

View full text Add to dashboard Cite

The Fourier transform (FT)-Raman spectroscopy technique is used to assess the biochemical alterations that occur in the degenerative process of the rotator cuff supraspinatus tendon. The main alterations observed occur in the glycine, proline, hydroxyproline, cysteine, cistine, phenylalanine, tyrosine, collagen I and III, nucleic acid, lipids, glycosaminoglycans, and metalloproteinases bands. An increasing intensity for these bands is found in degenerated tendons, a finding well correlated with hyaline state and cellular activity. Statistical analysis (principal components analysis and clustering) shows a clear separation of the spectra into nonhyalinized and hyalinized clusters, which enables the construction of a binary diagnosis model based on logistic regression. Best diagnosis provided a sensitivity of 66.0% and a specificity of 74.7% with 79.6% concordant pairs. The discriminating power of the diagnostic test is assessed by computing the area under the receiving-operator characteristic curve (AUC), which indicates good accuracy (AUC=0.81). In principle, these results indicate that Raman spectroscopy can be used as an auxiliary aid to improve shoulder tendon surgery quality by guiding anchoring onto more healthy (nonhyaline) pieces of tendons. This should contribute to a decrease in the current high rerupture rate (13 to 68%) for this procedure.

show abstract

Section: Introductionmentioning

confidence: 99%