Classification, staging and prognosis of lung cancer

Beadsmoore, Clare; Screaton, Nicholas

doi:10.1016/s0720-048x(02)00287-5

Cited by 124 publications

(130 citation statements)

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“…We found that surgical intervention fractions in this study (16.7% for NSCLC and 12.4% NSCLC/SCLC) were approximately two thirds of the European rates and one half of that reported from Victoria and in the review article, but similar to those reported from Scotland and Virginia (Campbell et al, 2002, Smith et al, 1995. The small proportion of patients with SCLC in this study who received surgery was consistent with figures reported by Beadsmoore et al (2003) of approximately one per cent. As elsewhere WA also saw a shift to less extensive surgery and away from pneumonectomy to lobectomy and resection (Waller, 2001).…”

Section: Discussionsupporting

confidence: 89%

“…Given that most lung cancer is smokingrelated (Beadsmoore et al, 2003), the continued efforts of health promoters, health care workers and others to reduce the prevalence of smoking in the community is the cornerstone to lung cancer control. Results of tobacco control policies are already being seen in the reduced incident rate of lung cancer in males (AIHW, 2002, AIHW & AACR, 2002.…”

Section: Discussionmentioning

confidence: 99%

“…Non-small cell lung cancer (NSCLC) comprises about 80% of all lung cancer and consists of adenocarcinoma (including bronchoalveolar carcinoma), adenosquamous, squamous and large cell. The prognosis after a diagnosis of NSCLC is poor with only 10-15% of patients surviving five years or longer (Beadsmoore et al, 2003, van Dijck et al, 2001, Novello et al, 2001, Alpard et al, 1999, Richardson et al, 2000, AIHW & AACR, 2003, whilst for small cell lung cancer (SCLC) the five-year survival is even worse at 1-5% (Beadsmoore et al, 2003). A reason for the poor prognosis of lung cancer in general is the lateness of presentation, with many already having lymph-node involvement and metastatic spread (van Dijck et al, 2001).…”

Section: Introductionmentioning

confidence: 99%

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The influence of socio-economic and locational disadvantage on patterns of surgical care for lung cancer in Western Australia 1982-2001

Hall¹,

Holman²,

Sheiner³

2004

Aust. Health Review

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Objective: Patterns of in-hospital surgical care for lung cancer in Western Australia were examined, including the effects of demographic, locational and socio-economic disadvantage and the possession of private health insurance, on the likelihood of receiving surgery. Patients and methods:The WA Record Linkage Project was used to extract hospital morbidity, cancer and death records of all people with lung cancer in Western Australia from 1982 to 2001. The likelihood of receiving lung cancer surgery was estimated, after adjustment for co-variates, using logistic regression.Results: Overall, 16% of patients received surgery for their lung cancer, although this varied according to histology. Patients who received surgery were typically younger, female, non-indigenous and had less comorbidity. Patients from socio-economically disadvantaged groups tended to be less likely to receive surgery (OR 0.79; 95% CI 0.61-1.04) although this was not significant for each category of disadvantage. Those who had their first hospital admission, with a mention of lung cancer, in a rural hospital were less likely to receive surgery (OR 0.26; 95% CI 0.19-0.36) than those in metropolitan hospitals, although residential location generally had less effect (OR 0.36; 95% CI 0.14-0.92). Patients admitted as a private patient either to a private or public hospital for their first mention of lung cancer had increased likelihood of receiving surgery (OR 1.15; 95% CI 1.02-1.30); however first admission to a private hospital had no effect (OR 0.99: 95% CI 0.85-1.16). Conclusion:The utilisation of lung cancer surgery was low with several factors found to affect the rate. Patients from socio-economically or locationally disadvantaged backgrounds, indigenous patients or patients without private health insurance were less likely to receive lung cancer surgery than those from more advantaged groups.

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Section: Discussionsupporting

confidence: 89%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The influence of socio-economic and locational disadvantage on patterns of surgical care for lung cancer in Western Australia 1982-2001

Hall¹,

Holman²,

Sheiner³

2004

Aust. Health Review

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“…Bronchioloalveolar carcinoma, defined as a non-invasive subtype of lung adenocarcinoma, 3 is recognized as ground-glass opacity lesion on computed tomography and is reported to have a good prognosis. 4 However, the overall 5-year survival of patients with stageIA (T1N0M0: T1, tumor greatest dimension r30 mm and surrounded by pleura; N0, no regional lymph node metastasis; M0, no distant metastasis) 5 adenocarcinomas does not reach 80%, 6,7 which indicates the existence of a poor prognostic group. Factors including smoking history, serum level of carcinoembryonic antigen, and tumor size, as well as lymphatic and venous invasion have been identified as poor prognostic factors for lung adenocarcinoma.…”

Section: Introductionmentioning

confidence: 99%

Histopathological features and prognostic significance of the micropapillary pattern in lung adenocarcinoma

et al. 2008

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The micropapillary pattern is characterized by small papillary tufts with no fibrovascular core lying in spaces and has been reported as an aggressive variant of carcinoma in several organs. We investigated the histopathobiological properties of the micropapillary pattern with immunohistochemistry, serial sections, and electron microscopy in lung adenocarcinoma. We further analyzed its clinicopathological character and prognosis. The subjects included 383 adenocarcinoma cases, of which 184 (48%) were micropapillary patternpositive and 199 (52%) were micropapillary pattern-negative. On histology, micropapillary tufts seemed to float in the alveolar space or spaces encased by connective tissues, whereas serial sections revealed that most tufts had continuity with other tufts and even with the main tumor. Positive staining for the adhesion molecules E-cadherin and b-catenin suggested the preservation of tight adhesion, and electron microscopy showed the existence of intercellular junctions. Negative staining for laminin and loss of basement membrane as determined by electron microscopy suggest a loss of cell-matrix contact. Positive staining for Ki-67 indicates that cells constituting micropapillary tufts retained their proliferation potency. There were no CD34-positive cells in micropapillary tufts, and the loss of the vascular core was confirmed. In micropapillary pattern-positive cases, lymphatic invasion was identified significantly more frequently than in micropapillary pattern-negative cases (Po0.001), even at stageIA (without lymph node metastasis, N ¼ 197) (Po0.001). The 5-year and 10-year overall survival rates of the micropapillary pattern-positive stageIA group were 77.6 and 67.6%, respectively, which were significantly less than those of the micropapillary pattern-negative stageIA group (98.1 and 98.1%) (P ¼ 0.001). In conclusion, cells constituting the micropapillary pattern are likely to have acquired anchorage-independent growth and a potential for high malignancy.

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“…Despite complete surgical resection, its prognosis is generally poor (1), with recurrence rates of 15-30% and 5-year survival rates of 60-70% (3). Lung cancer is commonly classified into four histological types: squamous cell carcinoma (SqCC), adenocarcinoma, large cell carcinoma, and small cell carcinoma (1,11), and adenocarcinoma and SqCC are considered as the two major types. Customized chemotherapy for unresectable or recurrent lung cancers is more frequently used for adenocarcinoma than for SqCC (19,21).…”

mentioning

confidence: 99%

<b>Podoplanin expression is correlated with the prognosis of lung squamous cell car</b><b>cinoma </b>

et al. 2015

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Podoplanin is a 38 kDa transmembrane protein that is involved in cell migration and cancer cell invasion. Some studies have reported that podoplanin expression was correlated with poor prognosis in lung squamous cell carcinoma (SqCC). However, there have been no clinicopathological studies of podoplanin membrane expression and localization in lung SqCC. In this study, we focused on the intensity and localization of podoplanin membrane expression, and its clinicopathological significance for lung SqCC. Strong membrane expression of podoplanin was significantly associated with lymph node metastasis, lymphatic invasion, and histological differentiation.

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Classification, staging and prognosis of lung cancer

Cited by 124 publications

References 40 publications

The influence of socio-economic and locational disadvantage on patterns of surgical care for lung cancer in Western Australia 1982-2001

The influence of socio-economic and locational disadvantage on patterns of surgical care for lung cancer in Western Australia 1982-2001

Histopathological features and prognostic significance of the micropapillary pattern in lung adenocarcinoma

<b>Podoplanin expression is correlated with the prognosis of lung squamous cell car</b><b>cinoma </b>

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