Classification, structure and mechanism of antiviral polysaccharides derived from edible and medicinal fungus

Guo, Yuxi; Chen, Xuefeng; Gong, Pin

doi:10.1016/j.ijbiomac.2021.05.139

Cited by 63 publications

(31 citation statements)

References 214 publications

(349 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Edible fungi, which belong to the phylum fungi, can form large fleshy (or colloidal) fruiting bodies or sclerotia tissues and can be used for food or medicine ( Guo et al, 2021 ). Polysaccharides extracted and purified from the fruiting body or mycelium have multiple physiological functions.…”

Section: Discussionmentioning

confidence: 99%

Scorias spongiosa Polysaccharides Promote the Antioxidant and Anti-Inflammatory Capacity and Its Effect on Intestinal Microbiota in Mice

Zhang

Feng

et al. 2022

Front. Microbiol.

View full text Add to dashboard Cite

Scorias spongiosa, as an edible fungus, has multiple health benefits. However, the effects of S. spongiosa on intestinal health are rarely explored. Hence, our study aims to elaborate on the influences of S. spongiosa polysaccharides (SSPs) on antioxidant, anti-inflammatory, and intestinal microflora in C57BL/6J mice. In the present study, 18 male mice were randomly distributed into three groups: (1) Control group (CON); (2) Low dose SSPs group (LSSP); (3) High dose SSPs group (HSSP). After 14-day administration, the jejunum and serum samples were collected for detection. The results showed that SSPs exert no effects on the growth performance of mice regardless of doses. Meanwhile, SSPs administration reduced the serum pro-inflammatory cytokines and elevated the anti-inflammatory cytokines. Moreover, the antioxidant capacity was elevated by SSPs administration, as evidenced by the increased contents of T-AOC, GSH-Px, and the decreased content of MDA. Mechanistically, the administration of SSPs enhanced the protein abundances of p-Nrf2, Keap1, and HO-1 in mice. The results of 16S rDNA demonstrated that the microbial community and composition were altered by SSPs administration. To summarize, SSPs benefit intestinal health in C57BL/6J mice via a mechanism that involves elevating antioxidant and anti-inflammatory activities and regulating intestinal microbiota.

show abstract

Section: Discussionmentioning

confidence: 99%

Scorias spongiosa Polysaccharides Promote the Antioxidant and Anti-Inflammatory Capacity and Its Effect on Intestinal Microbiota in Mice

Zhang

Feng

et al. 2022

Front. Microbiol.

View full text Add to dashboard Cite

show abstract

“…Polysaccharides have been derived from Coriolus versicolor, Poria cocos, Polyporus umbellatus, Lentinula edodes, and Lentinula edodes. These drugs are involved in the treatment of chronic hepatitis and some immune disorders and are also used to reduce the side effects of chemotherapeutic agents [74].…”

Section: Polysaccharides With Antiviral Activitiesmentioning

confidence: 99%

Polysaccharides and Their Derivatives as Potential Antiviral Molecules

Claus-Desbonnet

Nikly

Nalbantova

et al. 2022

Viruses

View full text Add to dashboard Cite

In the current context of the COVID-19 pandemic, it appears that our scientific resources and the medical community are not sufficiently developed to combat rapid viral spread all over the world. A number of viruses causing epidemics have already disseminated across the world in the last few years, such as the dengue or chinkungunya virus, the Ebola virus, and other coronavirus families such as Middle East respiratory syndrome (MERS-CoV) and severe acute respiratory syndrome (SARS-CoV). The outbreaks of these infectious diseases have demonstrated the difficulty of treating an epidemic before the creation of vaccine. Different antiviral drugs already exist. However, several of them cause side effects or have lost their efficiency because of virus mutations. It is essential to develop new antiviral strategies, but ones that rely on more natural compounds to decrease the secondary effects. Polysaccharides, which have come to be known in recent years for their medicinal properties, including antiviral activities, are an excellent alternative. They are essential for the metabolism of plants, microorganisms, and animals, and are directly extractible. Polysaccharides have attracted more and more attention due to their therapeutic properties, low toxicity, and availability, and seem to be attractive candidates as antiviral drugs of tomorrow.

show abstract

“…Therefore, the development of a natural drug with fewer side effects has become a major point of current diabetes mellitus research [2]. In recent years, several plant polysaccharides have been shown to exhibit improved hypoglycemic activity and can improve insulin resistance (IR) with low toxicity and side effects [3][4][5][6][7][8][9][10].…”

Section: Introductionmentioning

confidence: 99%

Structural Characteristics, Antioxidant and Hypoglycemic Activities of Polysaccharide from Siraitia grosvenorii

et al. 2022

Self Cite

View full text Add to dashboard Cite

The structural characterization, the in vitro antioxidant activity, and the hypoglycemic activity of a polysaccharide (SGP-1-1) isolated from Siraitia grosvenorii (SG) were studied in this paper. SGP-1-1, whose molecular weight is 19.037 kDa, consisted of Gal:Man:Glc in the molar ratio of 1:2.56:4.90. According to the results of methylation analysis, GC–MS, and NMR, HSQC was interpreted as a glucomannan with a backbone composed of 4)-β-D-Glcp-(1→4)-, α-D-Glcp-(1→4)-, and 4)-Manp-(1 residues. α-1,6 linked an α-D-Galp branch, and α-1,6 linked an α-D-Glcp branch. The study indirectly showed that SGP-1-1 has good in vitro hypoglycemic and antioxidant activities and that these activities may be related to the fact that the SGP-1-1’s monosaccharide composition (a higher proportion of Gal and Man) is the glycosidic-bond type (α- and β-glycosidic bonds). SGP-1-1 could be used as a potential antioxidant and hypoglycemic candidate for functional and nutritional food applications.

show abstract

Classification, structure and mechanism of antiviral polysaccharides derived from edible and medicinal fungus

Cited by 63 publications

References 214 publications

Scorias spongiosa Polysaccharides Promote the Antioxidant and Anti-Inflammatory Capacity and Its Effect on Intestinal Microbiota in Mice

Scorias spongiosa Polysaccharides Promote the Antioxidant and Anti-Inflammatory Capacity and Its Effect on Intestinal Microbiota in Mice

Polysaccharides and Their Derivatives as Potential Antiviral Molecules

Structural Characteristics, Antioxidant and Hypoglycemic Activities of Polysaccharide from Siraitia grosvenorii

Contact Info

Product

Resources

About