Classifications of atherosclerotic plaque components with T1 and T2* mapping in 11.7 T MRI

2D Projection Maps of WSS and OSI Reveal Distinct Spatiotemporal Changes in Hemodynamics in the Murine Aorta during Ageing and Atherosclerosis

“…The 2D analysis of histological sections does not reflect the 3D properties of the aortic arch and regional characteristics of the plaque. Therefore, a three-dimensional assessment of plaque characteristics, such as morphological measurements with MRI [ 42 ] or utilization of light sheet microscopy techniques [ 43 ], combined with spatially resolved WSS mapping, should be applied to further uncover the interrelationship of hemodynamics and atherosclerosis development and progression in the future. The results of this study furthermore point to a possible link between radial strain and radial aortic dilatability.…”

Microstructural and mechanical insight into atherosclerotic plaques: an ex vivo DTI study to better assess plaque vulnerability

“…In comparison to ultrasound, computed tomography and optical coherence tomography, MRI is both non-ionising and offers unparalleled soft tissue contrast. A number of studies have used ex vivo MRI to characterise plaque components (Harteveld et al 2016 ; Truong, et al 2021 ; Azuma et al 2020 ; Meletta et al 2015 ; Karmonik et al 2006 ; Morrisett et al 2003 ; Clarke et al 2003 ; Shinnar et al 1999 ). These studies utilise different combinations of T1-, T2-, proton-density, and diffusion weighted imaging to gain insight into the plaque composition.…”

“…These studies utilise different combinations of T1-, T2-, proton-density, and diffusion weighted imaging to gain insight into the plaque composition. The presence of necrotic cores (Meletta et al 2015 ; Clarke et al 2003 ), lipid cores (Harteveld et al 2016 ; Truong, et al 2021 ; Meletta et al 2015 ; Karmonik et al 2006 ; Shinnar et al 1999 ; Toussaint et al 1997 ), calcifications (Harteveld et al 2016 ; Azuma et al 2020 ; Meletta et al 2015 ; Karmonik et al 2006 ; Morrisett et al 2003 ; Clarke et al 2003 ; Shinnar et al 1999 ), fibrous tissue (Harteveld et al 2016 ; Truong, et al 2021 ; Azuma et al 2020 ; Karmonik et al 2006 ; Morrisett et al 2003 ; Clarke et al 2003 ; Shinnar et al 1999 ) and fibrous caps (Harteveld et al 2016 ; Meletta et al 2015 ; Toussaint et al 1997 ), inflammation (Truong, et al 2021 ; Meletta et al 2015 ), hemorrhage (Truong, et al 2021 ), red blood cells (Azuma et al 2020 ), hemosiderin (Azuma et al 2020 ; Meletta et al 2015 ), neovascularization (Meletta et al 2015 ), thrombus (Karmonik et al 2006 ), and solid-state and liquid-lipid (Morrisett et al 2003 ) have all been investigated. While knowledge of the composition of atherosclerotic plaques is beneficial in characterising them, there still lacks a direct connection between composition and mechanical integrity.…”

Microstructural and mechanical insight into atherosclerotic plaques– an ex vivo DTI study to better assess plaque vulnerability

“…In comparison to ultrasound and computed tomography, magnetic resonance imaging (MRI) is both non-ionising and offers unparalleled soft tissue contrast. A number of studies have used ex vivo MRI to characterise plaque components [28][29][30][31][32][33][34][35] . These studies utilise different combinations of T1-, T2-, proton-density, and diffusion weighted imaging to gain insight into the plaque composition.…”

“…These studies utilise different combinations of T1-, T2-, proton-density, and diffusion weighted imaging to gain insight into the plaque composition. The presence of necrotic cores 31,34 , lipid cores 28,29,31,32,35,36 , calcifications 28,[30][31][32][33][34][35] , fibrous tissue [28][29][30][32][33][34][35] and fibrous caps 28,31,36 , inflammation 29,31 , hemorrhage 29 , red blood cells 30 , hemosiderin 30,31 , neovascularization 31 , thrombus 32 , and solid-state and liquid-lipid 33 have all been investigated. While knowledge of the composition of atherosclerotic plaques is beneficial in characterising them, there still lacks a direct connection between composition and mechanical integrity.…”