Classifying the Severity of Corneal Ulcers by Using the “1, 2, 3” Rule

Vital, Mark C.; Belloso, Marcel; Prager, Thomas C.; Lanier, Jeffrey Day

doi:10.1097/ico.0b013e31802b2e47

Cited by 36 publications

(42 citation statements)

References 8 publications

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“…One physician stated that his/her decision to culture was based on the "1, 2, 3" rule, which classifies corneal ulcers into 2 categories ("rarely sight-threatening" and "potentially sightthreatening") based on infiltrate size, location, and severity of anterior chamber reaction. 19 Results for the frequency of Gram staining were similar to the frequency of culturing, with cornea specialists significantly more likely than non-cornea specialists to perform Gram stain on corneal ulcers (40.7%637.7% of the time vs. 13.9%627.5% of the time, P,0.0001). Finally, therapy-resistant corneal ulcers were uncommon among the surveyed physicians (8.0%612.5%), but cornea specialists saw a significantly greater percentage of initially therapy-resistant ulcers than non-cornea specialists (14.3%617.0% vs. 4.3%66.6%, P,0.0001).…”

Section: Survey Of Demographicssupporting

confidence: 66%

Community Practice Patterns for Bacterial Corneal Ulcer Evaluation and Treatment

Park

Lee

Zhou

et al. 2015

Eye &Amp; Contact Lens: Science &Amp; Clinical Practice

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Section: Survey Of Demographicssupporting

confidence: 66%

Community Practice Patterns for Bacterial Corneal Ulcer Evaluation and Treatment

Park

Lee

Zhou

et al. 2015

Eye &Amp; Contact Lens: Science &Amp; Clinical Practice

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“…Cataract surgery often adversely affects the tear film status manifested as decreased BUT and increased corneal and conjunctival staining scores, subsequently leading to the diagnosis of postoperative dry eye 1,12–15. In patients with postoperative dry eye in this study, as well, both BUT and corneal and conjunctival staining scores were significantly deteriorated compared with preoperative levels after cataract surgery.…”

Section: Discussionmentioning

confidence: 48%

Effects of 3% diquafosol sodium ophthalmic solution on higher-order aberrations in patients diagnosed with dry eye after cataract surgery

Inoue¹,

Ochi²

2016

OPTH

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PurposeTo evaluate the effects of diquafosol sodium ophthalmic solution 3% (DQS) and artificial tears (AT) on higher-order aberrations (HOAs) in patients with dry eye after cataract surgery.DesignThis was a post hoc analysis of a previously conducted randomized clinical study.MethodsFifty-nine eyes from 42 patients (17 males and 25 females, aged 72.6±8.0 years) with verified or suspected dry eye at 4 weeks after cataract surgery were evaluated. The dry eye patients were randomly assigned to receive DQS or AT for 4 weeks. Tear breakup time (BUT), corneal and conjunctival fluorescein staining scores, and HOAs were analyzed before and after instillation. HOAs were measured consecutively for 10 seconds with a wavefront analyzer. Average HOAs, HOA fluctuations (fluctuation index [FI]) and changes in HOAs (stability index [SI]) were compared within and between the two groups.ResultsAfter 4 weeks of instillation, BUT significantly increased (P=0.001) compared with preinstillation values in the DQS group, but not in the AT group. This increase in BUT in the DQS group was significantly greater than in the AT group (P=0.014). Corneal and conjunctival fluorescein staining scores after instillation significantly improved compared with preinstillation values in the DQS group (P=0.018). In HOAs, the cornea aberration changed from an upward curve (a sawtooth pattern) to an almost constant value (a stable pattern) in the DQS group, but not in the AT group. In FI and SI, there were no significant changes in either group; however, FI and SI were significantly lower in the DQS group than in the AT group (both, P=0.004).ConclusionThe dry eye patients after cataract surgery had a visual dysfunction in HOAs. DQS is effective to treat dry eye disease after cataract surgery with improvement of visual function.

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“…Cellulose acetate strip (Tianjin Jingming New Technological Development Co., Ltd, Tianjin, People’s Republic of China) was firmly pressed against the sampled area for 20 seconds. The strip was immediately transferred into 95% alcohol and stained with periodic acid-Schiff 14. Cytology impression was performed at three visits, which were 3 days before and 1 month and 3 months after the injection.…”

Section: Methodsmentioning

confidence: 99%

Efficiency and safety of subconjunctival injection of anti-VEGF agent – bevacizumab – in treating dry eye

Jiang¹,

Lv²,

Qiu³

et al. 2015

DDDT

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PurposeDry eye is a chronic inflammatory ocular surface disease with high prevalence. The current therapies for dry eye remain to be unspecific and notcomprehensive. This study aims to explore safety and efficacy of a novel treatment – subconjunctival injection of bevacizumab – in dry eye patients.MethodsSixty-four eyes of 32 dry eye patients received subconjunctival injection of 100 μL 25 mg/mL bevacizumab. Dry eye symptoms, signs (corrected visual acuity, intraocular pressure, conjunctival vascularity, corneal staining, tear break-up time, Marx line score, and blood pressure), and conjunctival impression cytology were evaluated 3 days before and 1 week, 1 month, and 3 months after injection.ResultsSignificant improvements were observed in dry eye symptoms, tear break-up time, and conjunctival vascularization area at all the visits after injection compared to the baseline (P<0.05). The density of the goblet cell increased significantly at 1 month and 3 months after injection (P<0.05). There was no visual and systemic threat observed in any patient.ConclusionSubconjunctival injection of 100 μL 25 mg/mL bevacizumab is a safe and efficient treatment for ocular surface inflammation of dry eye disease.

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Classifying the Severity of Corneal Ulcers by Using the “1, 2, 3” Rule

Cited by 36 publications

References 8 publications

Community Practice Patterns for Bacterial Corneal Ulcer Evaluation and Treatment

Community Practice Patterns for Bacterial Corneal Ulcer Evaluation and Treatment

Effects of 3% diquafosol sodium ophthalmic solution on higher-order aberrations in patients diagnosed with dry eye after cataract surgery

Efficiency and safety of subconjunctival injection of anti-VEGF agent – bevacizumab – in treating dry eye

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Classifying the Severity of Corneal Ulcers by Using the “1, 2, 3” Rule

Cited by 36 publications

References 8 publications

Community Practice Patterns for Bacterial Corneal Ulcer Evaluation and Treatment

Community Practice Patterns for Bacterial Corneal Ulcer Evaluation and Treatment

Effects of 3% diquafosol sodium ophthalmic solution on higher-order aberrations in patients diagnosed with dry eye after cataract surgery

Efficiency and safety of subconjunctival injection of anti-VEGF agent &ndash; bevacizumab &ndash; in treating dry eye

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Product

Resources

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Efficiency and safety of subconjunctival injection of anti-VEGF agent – bevacizumab – in treating dry eye