Claudin-1, -2, -4, and -5: comparison of expression levels and distribution in equine tissues

Lee, Bonn; Kang, Hee Young; Lee, Dong‐Oh; Ahn, Changhwan; Jeung, Eui‐Bae

doi:10.4142/jvs.2016.17.4.445

Cited by 10 publications

(13 citation statements)

References 27 publications

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“…The claudin family of transmembrane proteins is integral constituent of the tight junction and is expressed in tissue and in cell-specific manners 39 . Moreover, changes in claudin proteins, especially upregulation of claudin-2 protein, in association with pathological leakiness has been widely described 13 , 15 .…”

Section: Discussionmentioning

confidence: 99%

Obesity-induces Organ and Tissue Specific Tight Junction Restructuring and Barrier Deregulation by Claudin Switching

Ahmad

Rah

Bastola

et al. 2017

Sci Rep

104

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Obesity increases susceptibility to multiple organ disorders, however, underlying mechanisms remain unclear. The subclinical inflammation assisted by obesity-induced gut permeability may underlie obesity-associated co-morbidities. Despite eminent clinical significance of the obesity led gut barrier abnormalities, its precise molecular regulation remains unclear. It is also unknown whether barrier deregulations, similar to the gut, characterize other vital organs in obese individuals. The claudin family of proteins is integral to the tight junction (TJ), the apical cell-cell adhesion and a key regulator of the epithelial barrier. Using comprehensive physiological and biochemical analysis of intestinal and renal tissues from high-fat diet fed mice, critical for maintaining metabolic homeostasis, this study demonstrates that profound TJ-restructuring by organ and tissue-specific claudin switching characterize obese organs. Protein expression and cellular distribution were examined. In-silico analysis further highlighted potential association of select claudins, modulated by the obesity, with signaling and metabolic pathways of pathological significance. In vitro studies using Leptin or DCA-treatment suggested causal significance of obesity-induced changes in tissue microenvironment in regulating barrier deregulations in tissue-specific manner. Overall, current findings advances our understanding of the molecular undertakings of obesity associated changes that help predispose to specific diseases and also identifies novel windows of preventive and/or therapeutic interventions.

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Section: Discussionmentioning

confidence: 99%

Obesity-induces Organ and Tissue Specific Tight Junction Restructuring and Barrier Deregulation by Claudin Switching

Ahmad

Rah

Bastola

et al. 2017

Sci Rep

104

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“…54–56 Interestingly, one of the claudin family proteins, claudin-7, when expressed in intestinal epithelium demonstrates a prominent basolateral membrane distribution compared with other claudins that localize primarily to the apical TJs in the intestinal epithelium. 57 Also of note, integrins have an important role in regulating the mucosal epithelial and immune homeostasis.…”

Section: The Historical Perspectivementioning

confidence: 99%

Gut permeability and mucosal inflammation: bad, good or context dependent

et al. 2017

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Inflammatory bowel disease (IBD) is a multifactorial disease. A breach in the mucosal barrier, otherwise known as “leaky gut,” is alleged to promote mucosal inflammation by intensifying immune activation. However, interaction between the luminal antigen and mucosal immune system is necessary to maintain mucosal homeostasis. Furthermore, manipulations leading to deregulated gut permeability have resulted in susceptibility in mice to colitis as well as to creating adaptive immunity. These findings implicate a complex but dynamic association between mucosal permeability and immune homeostasis; however, they also emphasize that compromised gut permeability alone may not be sufficient to induce colitis. Emerging evidence further supports the role(s) of proteins associated with the mucosal barrier in epithelial injury and repair: manipulations of associated proteins also modified epithelial differentiation, proliferation, and apoptosis. Taken together, the role of gut permeability and proteins associated in regulating mucosal inflammatory diseases appears to be more complex than previously thought. Herein, we review outcomes from recent mouse models where gut permeability was altered by direct and indirect effects of manipulating mucosal barrier-associated proteins, to highlight the significance of mucosal permeability and the non-barrier-related roles of these proteins in regulating chronic mucosal inflammatory conditions.

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“…The first extracellular loop is involved in the regulation of paracellular charge and ion selectivity. The second extracellular loop participates in adhesion of claudin-claudin interaction and works as a receptor for bacterial toxin [4,5]. The C-terminal end is the most heterogenic both in the sequence and length among claudins.…”

Section: Introductionmentioning

confidence: 99%

Claudins: New Players in Human Fertility and Reproductive System Cancers

Kozieł

Kowalska

Piastowska-Ciesielska

2020

Cancers

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Claudins are major integral proteins of tight junctions (TJs), the apical cell-cell adhesions that enable maintaining polarity of epithelial cells, their differentiation, and cell signaling. A number of studies have indicated that claudins might play a crucial role in both physiology and pathogenesis. Their tissue-specific expression was originally linked to the development of different types of cancer and triggered a hope to use them as diagnostic or prognostic markers. However, it seems that their expression is more complex than that, and undoubtedly, claudins participate in one of the most important molecular events in cells. This review summarizes the recent research evaluating the role of claudins in fertility and the most common endocrine-dependent cancers in the reproductive system and highlights the crucial role of claudins both in human fertility and the most common cancers.

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Claudin-1, -2, -4, and -5: comparison of expression levels and distribution in equine tissues

Cited by 10 publications

References 27 publications

Obesity-induces Organ and Tissue Specific Tight Junction Restructuring and Barrier Deregulation by Claudin Switching

Obesity-induces Organ and Tissue Specific Tight Junction Restructuring and Barrier Deregulation by Claudin Switching

Gut permeability and mucosal inflammation: bad, good or context dependent

Claudins: New Players in Human Fertility and Reproductive System Cancers

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