2006
DOI: 10.1016/j.humpath.2005.12.015
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Claudin-1 and claudin-2 differentiate fetal and embryonal components in human hepatoblastoma

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Cited by 40 publications
(33 citation statements)
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References 26 publications
(34 reference statements)
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“…Halász et al have recently demonstrated that in hepatoblastomas the expressions of claudin-1 and claudin-2 were significantly higher in the more differentiated fetal component when compared with the embryonal component of the tumor [24]. In our present work, tumors with heterogenous differentiation usually showed strong claudin-1 and -4 immunostaining in well-differentiated tumor parts and weak immunopositivity in less-differentiated ones.…”
Section: Discussionsupporting
confidence: 71%
“…Halász et al have recently demonstrated that in hepatoblastomas the expressions of claudin-1 and claudin-2 were significantly higher in the more differentiated fetal component when compared with the embryonal component of the tumor [24]. In our present work, tumors with heterogenous differentiation usually showed strong claudin-1 and -4 immunostaining in well-differentiated tumor parts and weak immunopositivity in less-differentiated ones.…”
Section: Discussionsupporting
confidence: 71%
“…Stem cell lines can be differentiated to hepatocyte-like cells implementing an in vitro model for the cancer cell formation from tissue stem cells [55]. During the differentiation process the continuous changes in the expression level of various genes can also be monitored [18,23,[56][57][58].…”
Section: Discussionmentioning
confidence: 99%
“…TJs play important role in hepatic differentiation, regeneration, and hepatocarcinogenesis [56,65]. To date the cell contacts and different components of hepatocytes [24,25,27,64].…”
Section: Discussionmentioning
confidence: 99%
“…Negative controls for nonspecific binding, incubated with secondary antibodies only, were processed and revealed no signals. For positive control of β-catenin immunoreaction we used human hepatoblastoma tissue previously reported to show nuclear positivity and analyzed for β-catenin mutation [28].…”
Section: Immunohistochemistrymentioning
confidence: 99%