1999
DOI: 10.1083/jcb.145.3.579
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Claudin-11/OSP-based Tight Junctions of Myelin Sheaths in Brain and Sertoli Cells in Testis

Abstract: Members of the newly identified claudin gene family constitute tight junction (TJ) strands, which play a pivotal role in compartmentalization in multicellular organisms. We identified oligodendrocyte-specific protein (OSP) as claudin-11, a new claudin family member, due to its sequence similarity to claudins as well as its ability to form TJ strands in transfected fibroblasts. Claudin-11/OSP mRNA was expressed in the brain and testis. Immunofluorescence microscopy with anti–claudin-11/OSP polyclonal antibody (… Show more

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Cited by 411 publications
(302 citation statements)
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“…Interestingly, altered TFN expression has been associated with schizophrenia and expression of TFN and MBP during development has been reported delayed in animals following chronic ethanol treatment [29,38,63]. CLDN11 is a developmentally regulated protein that is expressed in interlamellar strands of myelin sheaths [64,65], and is involved in establishment of tight-junctions in myelinating cells and has overlapping functions with PLP1 in maintaining myelin's structural integrity [66][67][68][69]. Based on these functions, decreased CLDN11 and TFN expression could compromise myelin function and structural integrity.…”
Section: Discussionmentioning
confidence: 99%
“…Interestingly, altered TFN expression has been associated with schizophrenia and expression of TFN and MBP during development has been reported delayed in animals following chronic ethanol treatment [29,38,63]. CLDN11 is a developmentally regulated protein that is expressed in interlamellar strands of myelin sheaths [64,65], and is involved in establishment of tight-junctions in myelinating cells and has overlapping functions with PLP1 in maintaining myelin's structural integrity [66][67][68][69]. Based on these functions, decreased CLDN11 and TFN expression could compromise myelin function and structural integrity.…”
Section: Discussionmentioning
confidence: 99%
“…There is no evidence for selective expression or higher expression levels of OSP in the optic nerve, although this has not been thoroughly investigated in rhesus monkeys. OSP mRNA and protein expression profiles demonstrate that OSP is present in Sertoli cells in the testis and in interlamellar strands of myelin sheaths throughout the CNS in mice [16,18,19,29], and OSP -/-mice are characterized by impaired CNS nerve conduction and not by optical problems [30]. In addition, optic neuritis has been reported to occur spontaneously in MOG-specific T cell receptor transgenic mice [31] and can be induced by immunization with MOG [32].…”
Section: Discussionmentioning
confidence: 99%
“…The non-compact regions of myelin contain 2',3'-cyclic nucleotide 3'-phosphodiesterase (CNP), myelinassociated glycoprotein (MAG), myelin/oligodendrocyte glycoprotein (MOG), the 155 kDa isoform of neurofascin (NF155), oligodendrocyte myelin glycoprotein (OMgp) and connexin-32 (Cx32) (Baumann and Pham-Dinh, 2001). A tight junctional array containing oligodendrocyte-specific protein/claudin-11 (OSP) marks the border between compact and non-compact myelin and may act as a diffusion barrier between these myelin subdomains (Bronstein et al, 2000;Gow et al, 1999;Krämer et al, 2001;Morita et al, 1999).…”
Section: Introductionmentioning
confidence: 99%