Clavacin, an Antibiotic Substance From Aspergillus Clavatus

Katzman, Philip A.; Hays, Edwin E.; Cain, C.K.; Wyk, J.J. Van; Reithel, F.J.; Thayer, Sidney A.; Doisy, Edward A.; Gaby, W. L.; Carroll, C.J.; Muir, R. D.; Jones, Lloyd R.; Wade, Nelson J.

doi:10.1016/s0021-9258(18)71930-3

Cited by 42 publications

(1 citation statement)

References 12 publications

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“…Patulin ( 3 ) also shows mutagenic and carcinogenic activity, because of its ability to inhibit DNA, RNA, and protein synthesis . Since its isolation in the 1930s, patulin ( 3 ) (isolated from Penicillium patulum ) has been known under several names, such as clavacin, clavatin, claviformin (isolated from P. claviforme ), expansin, mycoin, penicidin, and tercinin . Despite its apparently simple structure, patulin ( 3 ) has incited large interest within the field of natural product chemistry.…”

Section: Total Synthesismentioning

confidence: 99%

Chemistry and Biology of Mycotoxins and Related Fungal Metabolites

et al. 2009

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Table 2. Mycotoxins Produced by Aspergillus sp. fungus mycotoxin produced Aspergillus aculeatus Secalonic acid D (10) Aspergillus albertensis Ochratoxin A (7), Ochratoxin B (155) Aspergillus alliaceus Ochratoxin A (7), Ochratoxin B (155) Aspergillus auricomus Ochratoxin A (7), Ochratoxin B (155) Aspergillus bombycis Aflatoxin B 1 (1), Aflatoxin G (13) Aspergillus breVipes Viriditoxin Aspergillus caespitosus Fumitremorgin A Aspergillus candidus Citrinin (2), Acetylisoneosolaniol Aspergillus carneus Citrinin (2) Aspergillus claVatus Patulin (3), Tryptoquivaline A (C), Cytochalasin E (443) Aspergillus flaVipes Citrinin (2) Aspergillus flaVus Aflatoxin B 1 (1), Aflatoxin B 2 (15), Aflatoxin M 1 (12), Cyclopiazonic acid, Aflatrem (indole alkaloid), 3-Nitropropionic acid, Sterigmatocystin (62), Versicolorin A (597), Aspertoxin Aspergillus fresenii Xanthomegnin (591) Aspergillus fumigatus Fumitremorgin A, Verruculogen (543), Gliotoxin (527), Fumagillin, Helvolic acid, Sphingofungins, Brevianamide A (545), Phthioic acid, Fumigaclavin C, Aurasperone C Aspergillus giganteus Patulin (3) Aspergillus melleus Ochratoxin A (7), Viomellein, Xanthomegnin (591) Aspergillus microcysticus Aspochalasin Aspergillus nidulans (Emericella nidulans) Sterigmatocystin (62), Dechloronidulin, Emestrin Aspergillus niger Malformin, Ochratoxin A (7), Fumonisin B 2 (5) Aspergillus nomius Aflatoxin B 1 (1), Aflatoxin B 2 (15), Aflatoxin G 1 (13), Aflatoxin G 2 (19) Aspergillus ochraceoroseus Aflatoxin B 1 (1), Sterigmatocystin (62) Aspergillus ochraceus Ochratoxin A (7), Ochratoxin B (155), Ochratoxin C (156), Viomellein, Penicillic acid (187) Aspergillus oryzae Cyclopiazonic acid, Maltoryzine, 3-Nitropropionic acid Aspergillus ostianus Ochratoxin A (7) Aspergillus parasiticus Aflatoxin B 1 (1), Aflatoxin B 2 (15), Aflatoxin G 1 (13), Aflatoxin G 2 (19), Aflatoxin M 1 (12), Versicolorin A (597) Aspergillus petrakii Ochratoxin A (7) Aspergillus pseudotamarii Cyclopiazonic acid, Aflatoxin B 1 (1) Aspergillus restrictus Restrictocin Aspergillus sclerotiorum Ochratoxin B (155) Aspergillus sulfureus Ochratoxin A (7), Ochratoxin B (155)

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Section: Total Synthesismentioning

confidence: 99%

Chemistry and Biology of Mycotoxins and Related Fungal Metabolites

et al. 2009

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Occurrence and significance of mycotoxins in forage crops and silage: a review

Scudamore¹,

Livesey

1998

J. Sci. Food Agric.

176

127

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Study of mycotoxins in animal feeding stuffs has concentrated on the occurrence of aflatoxins and, to a lesser extent, other mycotoxins in cereals, raw materials and concentrate feeds. However, ruminant diets contain a high proportion of forage crops such as grass or maize silage, hay and straw. Under adverse growing, production or storage conditions, fungal spoilage is likely to occur with some degree of mycotoxin contamination. The mould flora of forage crops is likely to differ significantly from that of cereals and mycotoxin contamination, should it occur, could differ qualitatively and quantitatively. Information relating to forage crops as a potential source of mycotoxins is reviewed. Some field incidents and animal disease which may be mycotoxin related are discussed and analytical methods are reviewed. Information on dose and effect of candidate mycotoxins is given where available. The review suggests areas which the authors consider merit further study. Crown Copyright 1998.

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Antibacterial Substances from Fungi and Green Plants

Kavanagh¹

1947

Advances in Enzymology - And Related Areas of Molecular Biology

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Clavacin, an Antibiotic Substance From Aspergillus Clavatus

Cited by 42 publications

References 12 publications

Chemistry and Biology of Mycotoxins and Related Fungal Metabolites

Chemistry and Biology of Mycotoxins and Related Fungal Metabolites

Occurrence and significance of mycotoxins in forage crops and silage: a review

Antibacterial Substances from Fungi and Green Plants

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