Clavicular and meningeal alveolar soft part sarcoma: An unusual case and literature review

James, Aaron W.; Chang, Le; Levine, Benjamin D.; Dry, Sarah M.

doi:10.1016/j.jor.2013.12.014

Cited by 4 publications

(5 citation statements)

References 34 publications

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“…Other locations, such as the female genital tract [6], mediastinum [9], lung [10], gastrointestinal tract, are rare [11]. Primary bone involvement is occasional [12], and it characteristically involves the fibula, ileum and tibia [4]. Only 2 cases with primary involvement of the scapular bone have been previously reported in the literature [3].…”

Section: Discussionmentioning

confidence: 99%

“…Park and al. [13] The most characteristic finding in ASPS is the consistent demonstration of strong nuclear immunoreactivity for TFE3, reflecting the ASPSCR1-TFE3 fusion gene that had been identified by cytogenetic analysis [4] [14]. Recent studies have shown that the crystals are immunoreactive to a protein MCT1 (monocarboxylate transporter) and to CD 147 [15].…”

Section: Discussionmentioning

confidence: 99%

“…The differential diagnosis of ASPS [4] [17] involves a wide range of neoplasms that contain a similar alveolar nest-like pattern. This includes renal, adrenal and hepatocellular carcinomas, which have a similar eosinophilic cytoplasm, but are distinguished by cytokeratin markers.…”

Section: Discussionmentioning

confidence: 99%

“…Primary bone involvement is occasional, and characteristically involves the fibula, ileum and tibia [4]. Only 2 cases with primary involvement of the scapular bone have been reported previously in the literature [3].…”

Section: Introductionmentioning

confidence: 99%

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Primary Alveolar Soft Part Sarcoma of the Scapula

Sahraoui¹,

Boujelbène²,

Doghri³

et al. 2017

OJO

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Alveolar soft-part sarcoma (ASPS) is an uncommon, aggressive soft-tissue neoplasm, occurring in less than 1% of sarcomas. It is typically found in the head and neck tissues in children or in the deep soft tissues of the lower extremities in young adults. This tumor arises primarily within the skeletal muscles or musculofascial planes. Primary involvement of bone is extremely rare. ASPS has poor prognosis with a propensity for recurrence as well as distant metastasis. In this report, we present a 25-year-old male with primary ASPS in the left scapular bone and discuss the histopathological and immunohistochemical features of this sarcoma.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Primary Alveolar Soft Part Sarcoma of the Scapula

Sahraoui¹,

Boujelbène²,

Doghri³

et al. 2017

OJO

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“…The meningeal involvement was thought to be either primary or metastasis disease. 9 Typically, patients note a painless, slowly growing mass. An unusual clinical presentation with rapidly growing ASPS of the cheek has been recently reported.…”

mentioning

confidence: 99%

Alveolar Soft Part Sarcoma

Jaber¹,

Kirby

2015

Archives of Pathology &Amp; Laboratory Medicine

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Alveolar soft part sarcoma is a rare neoplasm usually arising in the soft tissues of the lower limbs in adults and in the head and neck region in children. It presents primarily as a slowly growing mass or as metastatic disease. It is characterized by a specific chromosomal alteration, der(17)t(X:17)(p11:q25), resulting in fusion of the transcription factor E3 (TFE3) with alveolar soft part sarcoma critical region 1 (ASPSCR1) at 17q25. This translocation is diagnostically useful because the tumor nuclei are positive for TFE3 by immunohistochemistry. Real-time polymerase chain reaction to detect the ASPSCR1-TFE3 fusion transcript on paraffin-embedded tissue blocks has been shown to be more sensitive and specific than detection of TFE3 by immunohistochemical stain. Cathepsin K is a relatively recent immunohistochemical stain that can aid in the diagnosis. The recent discovery of the role of the ASPSCR1-TFE3 fusion protein in the MET proto-oncogene signaling pathway promoting angiogenesis and cell proliferation offers a promising targeted molecular therapy.

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