Clavulanic acid and penicillin treatment of Staphylococcus aureus renal infection in mice

Abstract

Clavulanic acid, an inhibitor of beta-lactamase, was used together with penicillin to treat infection caused by a penicillinase-producing Staphylococcus aureus. Clavulanic acid + penicillin administered to mice, prophylactically or in treatment of established infection, reduced morbidity, bacterial counts in the kidneys, and/or mortality; these differences were statistically significant when compared with those obtained by using penicillin or clavulanic acid alone.

Clinical trial of the efficacy and safety of ticarcillin and clavulanic acid

“…Likewise, a combination of penicillin-clavulanic acid appears to provide effective therapy in a mouse model of staphylococcal renal infection, even when the infection is caused by a penicillinase-producing S. aureus (9). In a recent study of 20 patients with osteomyelitis documented by bone biopsy culture, TiClav was found to be effective in 15 of the 20 patients, with "cure" documented by repeat bone biopsy after therapy.…”