This study was carried out on the macrofungi samples collected from Silifke district of Mersin province. As a result, 122 macromycete species belonging to 89 genera, 48 families, 18 orders, and 7 classes, within Ascomycota and Basidiomycota were determined. Including the previously reported 11 species, a total of 133 macromycete taxa were compiled from the region. The list of the taxa was provided together with their habitats, collection dates, voucher numbers, and the citations for those reported before.