Clay and non-clay minerals in the pharmaceutical and cosmetic industries Part II. Active ingredients

Carretero, Marı́a Isabel; Pozo, Manuel

doi:10.1016/j.clay.2009.10.016

Cited by 302 publications

(226 citation statements)

References 17 publications

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“…Since montmorillonite and opal-CT in bentonite have similar speci c gravities (2.4 2.7 g/cm 3 ), gravity based methods are not suitable for the bene ciation of bentonite. The method based on the differences in particle size, therefore, would be a key role for the separation of them.…”

Section: Resultsmentioning

confidence: 99%

“…1) Among the special applications, bentonite is often used in the cosmetic and pharmaceutical industry as both excipient and active ingredient in the forms of liquid (suspensions, emulsions), semi-solid (creams, ointments) and solid (powder, capsules and tablets). [2][3][4] The basic requirements for bentonite to be used as raw material are pure, microbiological and mineralogical inertness. Physical properties such as swelling volume and gel formation are also important.…”

Section: Introductionmentioning

confidence: 99%

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Ultrasound-Assisted Removal of Microcrystalline Opal-CT from Ca-Bentonite

Kim

2016

Mater. Trans.

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Microcrystalline silica impurities such as quartz and opal-CT commonly associated in bentonite should be controlled and removed as far as possible when bentonite is used as biocompatible raw material because the impurities are hazardous in human health. Since opal-CT contained in Korean Ca-bentonite in trace amounts cannot be well separated by conventional sedimentation method, in this work, the ultrasound-assisted removal of the impurity was attempted. Irradiating ultrasound into bentonite-water suspension promoted the production of ne montmorillonite particles in the suspension and the production markedly increased when montmorillonite was activated by Na 2 CO 3 . Subsequent centrifugation of the suspension made it possible to recover pure montmorillonite particles as an over ow product. Only 16.2 mass% of total solids was recovered as an over ow from non-activated suspension, whereas 63.5 mass% was recovered from activated suspension at centrifuging speed of 10000 rpm. Increasing sonicating time enhanced the yield of over ow, however, excessive sonication up to 10 min hindered the high puri cation of montmorillonite. It was observed that the peak re ection of (101) plane of opal-CT in over ow increased as sonicating time increased during prolonged sonication.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Ultrasound-Assisted Removal of Microcrystalline Opal-CT from Ca-Bentonite

Kim

2016

Mater. Trans.

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“…Moreover, rice starch is often described as the most digestible starch in dogs versus other starch sources [19,20]. SENSI diet has been supplemented with Sepiolite (0.8% of the formula) which acts as clay: thanks to its high capacity to absorb excessive water and gas in the intestinal lumen, Sepiolite is aimed to normalize faeces consistency and flatulence [21,22]. Because of its demonstrated effectiveness in reducing faecal odour in a high protein diet as well as faecal ammonia and production of intestinal gases independently of protein content in the diet, Yucca schidigera extract has been incorporated to SENSI (representing 42 ppm of saponins in the diet) [23][24][25].…”

Section: Efficacy and Tolerance Of Two Lowcarbohydrate Diets In Largementioning

confidence: 99%

Efficacy and Tolerance of Two Low-Carbohydrate Diets in Large Adult Dogs with Digestive Sensitivity: A Randomized, Cross-Over, Blinded Evaluation

Leriche¹,

Ereau²,

Navarro³

et al. 2017

J Vet Med Surg

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“…국소적으로 점토광물을 피부에 도포했 을 경우에는 피부의 삼출물을 흡수하여 피부보호 효과 를 나타낼 수도 있다 (Carretero and Pozo, 2010;Hopkins, 1946 …”

Section: 서 론unclassified

Case Study of Pharmaceutical Ingredients Derived from Clay Minerals

Jin¹,

Lee²,

Hwang³

2015

Economic and Environmental Geology

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Clay minerals have been used in pharmaceutical industries as active ingredients and excipients without pharmacological activity such as diluents, emulsifying agents, viscosity-increasing agents, and lubricants. For example, bentonite, kaolin, magnesium aluminum silicate, and talc are generally and extensively used pharmaceutical ingredients, which are restrictedly regulated by Pharmacopoeias. We discuss the physicochemical and biopharmaceutical properties of clay minerals. In addition, we introduce the cases of pharmaceutical applications of clay minerals. From this review, pharmaceutical applications of clay minerals can be one of strategies for the development of high valueadded products from clay minerals.

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Clay and non-clay minerals in the pharmaceutical and cosmetic industries Part II. Active ingredients

Cited by 302 publications

References 17 publications

Ultrasound-Assisted Removal of Microcrystalline Opal-CT from Ca-Bentonite

Ultrasound-Assisted Removal of Microcrystalline Opal-CT from Ca-Bentonite

Efficacy and Tolerance of Two Low-Carbohydrate Diets in Large Adult Dogs with Digestive Sensitivity: A Randomized, Cross-Over, Blinded Evaluation

Case Study of Pharmaceutical Ingredients Derived from Clay Minerals

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