Clay-based hybrids for controlled release of 7-azaindole derivatives as neuroprotective drugs in the treatment of Alzheimer's disease

García-Vázquez, Rocio; Rebitski, Ediana P.; Viejo, Lucía; Rı́os, Cristóbal de los; Darder, Margarita; García-Frutos, Eva M.

doi:10.1016/j.clay.2020.105541

Cited by 23 publications

(12 citation statements)

References 36 publications

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“…This unique feature provides halloysite with two different surfaces . For instance, the external surface of HNTs is composed of silicon oxygen tetrahedrons, whereas the internal lumen consists of alumina oxygen octahedrons, so that the outer surface is distributed mainly with Si-O-Si groups and the inner surface is composed of Al-OH. , As a consequence, the former is negatively charged while the latter is positively charged in the 2–8 pH range, and they can be selectively modified by both electrostatic and covalent functionalization in order to tailor the nanoclay physicochemical properties, thus exploiting the different chemistry of the groups each surface is bearing and their different charges. , Most importantly, the inner volume of the clay can be loaded with active species and biomolecules for storage and delivery purposes. − Different in vitro and in vivo studies also reported that HNTs are not toxic and they show cyto-compatibility. , …”

Section: Introductionmentioning

confidence: 99%

Hydroxypropyl Cellulose Films Filled with Halloysite Nanotubes/Wax Hybrid Microspheres

Lisuzzo

Caruso

Cavallaro

et al. 2021

Ind. Eng. Chem. Res.

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The design of novel nanocomposite films based on hydroxypropyl cellulose (HPC) and wax/halloysite hybrid microspheres has been reported. In particular, we first prepared wax/clay Pickering emulsions which were characterized by thermogravimetric analysis and microscopy. SEM images allowed more detailed insights on the nanotubes disposition at the wax/water interface, acting as an outer stabilizing shell. Therefore, the cellulosic biopolymer was added, and it was found that HPC enhances the colloidal stability of the particles, preventing their coalescence and sedimentation. The preparation of the composite films was carried out by the solvent casting method, which enabled the development of very homogeneous materials. Contact angle and sliding angle measurements showed that the increasing amount of wax/halloysite microparticles into the biopolymeric matrix is responsible for an enhanced hydrophobic nature of the films and, at the same time, it facilitates the rolling process of droplets on the surfaces, thus making the prepared materials promising protective coatings. These findings were also confirmed by the decrease of the vapor permeability of the nanocomposites, which can act as a gas barrier. Moreover, the effect of the composition on the optical properties, namely transparency and colorimetric features, was investigated together with the thermal properties of the films. Results demonstrated that the presence of wax/halloysite microspheres as fillers within the HPC matrix has profound effects on the prepared systems, which were evaluated to be good energy storage and heat reservoir materials. In light of these aspects, the new HPC/wax/halloysite nanocomposites represent promising tools for the surface modification.

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Section: Introductionmentioning

confidence: 99%

Hydroxypropyl Cellulose Films Filled with Halloysite Nanotubes/Wax Hybrid Microspheres

Lisuzzo

Caruso

Cavallaro

et al. 2021

Ind. Eng. Chem. Res.

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“…LDH's include a variety of chemical compounds produce various poly-types of layered structures, such as; MMT's AlNa12SiO3 nanoparticles (cationic) have highly layered internal-surface. The core structure consists of an octagonaltwisted sheet composed of quadrilateral layers [39,40].…”

Section: Structural Propertiesmentioning

confidence: 99%

Micro and Nano Clay-Biopolymer Composites for Drug Delivery

Jabeen¹

2022

Materials Research Foundations

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Clay-based biopolymers are among the most efficient and cost-effective composite materials that find applications in a variety of biomedical applications such as drug delivery. This chapter elaborates the different physical, chemical, and structural properties of clay biopolymeric composites, which makes them most reliable to use for the applications of drug delivery. The main focus of writing this chapter is to explore the composition, structural properties, and route of action of clay-based nanomaterials, along with elaborating the mechanism of the drug delivery system. The synthesis of clay-encapsulated drug formulation and their route of administration has been investigated in this chapter. Data for the synthesis of composites and in vitro study has also been included from the existing literature.

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“…14,15 Clays had so far been used as a carrier for such drugs such as cyclodextrin, 5-fluorouracil, ciprofloxacin, tetracycline, 5-aminosalicylic acid and 7-azaindole which were used as antibiotics, neuroprotective drugs, anti-cancer drugs and anti-inflammatory drugs. [16][17][18][19][20] Despite so many reports on the use of this type of material as drug carriers and the continuous high interest in them, they have not yet been used as a carrier of bisphosphonates. Montmorillonite was also used as an element of composites, which was then used for controlled vaginal drug delivery and for bone tissue engineering.…”

Section: Introductionmentioning

confidence: 99%

Calcium montmorillonite as a potential carrier in the release of bisphosphonates

Sandomierski¹,

Zielińska²,

Adamska³

et al. 2022

New J. Chem.

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Clay-based hybrids for controlled release of 7-azaindole derivatives as neuroprotective drugs in the treatment of Alzheimer's disease

Cited by 23 publications

References 36 publications

Hydroxypropyl Cellulose Films Filled with Halloysite Nanotubes/Wax Hybrid Microspheres

Hydroxypropyl Cellulose Films Filled with Halloysite Nanotubes/Wax Hybrid Microspheres

Micro and Nano Clay-Biopolymer Composites for Drug Delivery

Calcium montmorillonite as a potential carrier in the release of bisphosphonates

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