Clay–Organic Interfaces for Design of Functional Hybrid Materials

Darder, Margarita; Wicklein, Bernd; Rytwo, Giora; Ruiz‐Hitzky, Eduardo

doi:10.1002/9783527807130.ch1

Cited by 13 publications

(12 citation statements)

References 349 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The potential use of edible clays for reducing dietinduced hypercholesterolemia and obesity in rodents has been suggested in recent studies. [13][14][15][16][17] However, those experiments used MMT, which was found to be less effective than sepiolite in adsorption of crude oils, 20,36 cholesterol, and olive oil (see our in vitro results and Refs. 21,36 ).…”

Section: Discussionmentioning

confidence: 87%

“…[13][14][15][16][17] However, those experiments used MMT, which was found to be less effective than sepiolite in adsorption of crude oils, 20,36 cholesterol, and olive oil (see our in vitro results and Refs. 21,36 ). Therefore, we believe that sepiolite will have greater efficacy as a monotherapeutic agent for the combination of obesity, hypercholesterolemia, and hyperlipidemia, than MMT.…”

Section: Discussionmentioning

confidence: 87%

“…It is yet to be determined whether the in vivo mode of action of sepiolite as an antihypercholesterolemia agent is by adsorbing dietary cholesterol, adsorbing biliary cholesterol (which will also prevent emulsification of cholesterol, further inhibiting its absorption), or both. However, previously published in vitro data show that needle-like clays, such as sepiolite and palygorskite, have a measurable advantage over plate-like clays, such as bentonite or MMT, in adsorbing hydrophobic molecules 36 -suggesting that sepiolite's in vivo mode of action as an antihypercholesterolemia agent is mainly by adsorbing nonpolar dietary sterol and not as the adsorbent of amphipathic biliary sterol.…”

Section: Discussionmentioning

confidence: 96%

See 2 more Smart Citations

Sepiolite Clay Attenuates the Development of Hypercholesterolemia and Obesity in Mice Fed a High-Fat High-Cholesterol Diet

Gutman

Rauch

Neuman

et al. 2020

Journal of Medicinal Food

Self Cite

View full text Add to dashboard Cite

Obesity reduces the quality of life and life expectancy, whereas nonoperative interventions have shown poor results so far. Statins effectively combat hypercholesterolemia but are not well tolerated at high doses, raising the need for coprescription with cholesterol sorbents and/or absorption inhibitors. Montmorillonite (MMT) clay was found to attenuate hypercholesterolemia and obesity by reducing cholesterol and fat absorption. However, acicular clay-like sepiolite may offer better results due to its more substantial adsorption of nonpolar molecules. We herein aimed at (1) assessing in vitro the capacity of sepiolite to adsorb edible oil and cholesterol compared with that of MMT and (2) assessing in vivo the effect of continuous feeding on a high-fat high-cholesterol diet (HFD) (53.6% w/w fat and 0.2% cholesterol) supplemented with 5% (w/w) edible sepiolite, on diet-induced obesity rate, hypercholesterolemia, and hyperlipidemia. Fourier transform infrared spectroscopy showed in vitro that sepiolite adsorption of olive oil and cholesterol was five to eight times greater than that of MMT clay. Sepiolite supplementation to HFD fed to mature mice for 12.5 weeks resulted in lower total blood cholesterol and triacylglycerol levels and attenuated body weight gain, by reducing fat gain. Sepiolite supplementation did not affect energy intake but increased fecal extraction of sterols and lipids, without notable side effects. These results demonstrate that supplementing a HFD with sepiolite attenuates gastrointestinal absorption of dietary lipids and sterols, thus mitigating obesity, hyperlipidemia, and hypercholesterolemia. Further exploration of the efficacy, mechanism of action, and safety of sepiolite as a food supplement for combating the metabolic syndrome is needed.

show abstract

Section: Discussionmentioning

confidence: 87%

Section: Discussionmentioning

confidence: 87%

Section: Discussionmentioning

confidence: 96%

See 1 more Smart Citation

Sepiolite Clay Attenuates the Development of Hypercholesterolemia and Obesity in Mice Fed a High-Fat High-Cholesterol Diet

Gutman

Rauch

Neuman

et al. 2020

Journal of Medicinal Food

Self Cite

View full text Add to dashboard Cite

show abstract

“…There are diverse methodologies and synthesis strategies to provide new functionalities to clays. Particularly useful for constructing nanoarchitectures is the use of organic–inorganic interphases as those provided by organoclays [12]. Besides typical 2D layered clays, fibrous (sepiolite, palygorskite) and tubular (halloysite, imogolite) clays are attracting growing interest in the development of a large variety of functional nanomaterials and nanocomposites for application in diverse fields [13–15].…”

Section: Introductionmentioning

confidence: 99%

“…Examples are the direct assembly of carbon nanotubes and sepiolite under ultrasonic irradiation [19] and the generation of layered titanosilicates in the presence of sepiolite [20]. In this context, the use of organic–inorganic interphases has proved highly effective to facilitate the co-assembly process, which favors the formation of more homogeneous and, in general, better organized nanoarchitectures [12].…”

Section: Introductionmentioning

confidence: 99%

Layered double hydroxide/sepiolite hybrid nanoarchitectures for the controlled release of herbicides

Rebitski¹,

Darder²

2019

Beilstein J. Nanotechnol.

Self Cite

View full text Add to dashboard Cite

In this work, organic–inorganic hybrid nanoarchitectures were prepared in a single coprecipitation step by assembling magnesium–aluminum layered double hydroxides (MgAl-LDH) and a sepiolite fibrous clay, with the simultaneous encapsulation of the herbicide 2-methyl-4-chlorophenoxyacetic acid (MCPA) as the MgAl-LDH retains its ion exchange properties. The synthetic procedure was advantageous in comparison to the incorporation of MCPA by ion exchange after the formation of the LDH/sepiolite nanoarchitecture in a previous step, as it was less time consuming and gave rise to a higher loading of MCPA. The resulting MCPA-LDH/sepiolite nanoarchitectures were characterized by various physicochemical techniques (XRD, FTIR and 29Si NMR spectroscopies, CHN analysis and SEM) that revealed interactions of LDH with the sepiolite fibers through the silanol groups present on the outer surface of sepiolite, together with the intercalation of MCPA in the LDH confirmed by the increase in the basal spacing from 0.77 nm for the pristine LDH to 2.32 nm for the prepared materials. The amount of herbicide incorporated in the hybrid nanoarchitectures prepared by the single-step coprecipitation method surpassed the CEC of LDH (ca. 330 mEq/100 g), with values reaching 445 mEq/100 g LDH for certain compositions. This suggests a synergy between the inorganic solids that allows the nanoarchitecture to exhibit better adsorption properties than the separate components. Additionally, in the release assays, the herbicide incorporated in the hybrid nanoarchitectures could be completely released, which confirms its suitability for agricultural applications. In order to achieve a more controlled release of the herbicide and to act for several days on the surface of the soil, the hybrid nanoarchitectures were encapsulated in a biopolymer matrix of alginate/zein and shaped into spheres. In in vitro tests carried out in bidistilled water, a continuous release of MCPA from the bionanocomposite beads was achieved for more than a week, while the non-encapsulated materials released the 100% of MCPA in 48 h. Besides, the encapsulation may allow for better handling and transport of the herbicide.

show abstract

Immobilization of Nanoparticles on Fibrous Clay Surfaces: Towards Promising Nanoplatforms for Advanced Functional Applications

Aranda

Ruiz‐Hitzky

2018

The Chemical Record

View full text Add to dashboard Cite

This account discusses on diverse general approaches employed for the preparation of heterostructured materials based on the immobilization of metal oxides and other nanoparticles on sepiolite and palygorskite fibrous clay minerals, showing the many opportunities of application offered by the resulting materials. Various examples from our own experience have been selected to show how sepiolite acts as a convenient nanoplatform for immobilization of diverse type of nanoparticles, such as TiO , Fe O , Prussian blue, zeolites, layered double hydroxides, carbon nanotubes and graphenes, etc., to produce functional materials for applications in catalysis, environmental remediation, sensing devices, energy production, and others.

show abstract

Clay–Organic Interfaces for Design of Functional Hybrid Materials

Cited by 13 publications

References 349 publications

Sepiolite Clay Attenuates the Development of Hypercholesterolemia and Obesity in Mice Fed a High-Fat High-Cholesterol Diet

Sepiolite Clay Attenuates the Development of Hypercholesterolemia and Obesity in Mice Fed a High-Fat High-Cholesterol Diet

Layered double hydroxide/sepiolite hybrid nanoarchitectures for the controlled release of herbicides

Immobilization of Nanoparticles on Fibrous Clay Surfaces: Towards Promising Nanoplatforms for Advanced Functional Applications

Contact Info

Product

Resources

About