Clays and Wound Healing

Tian, Guangjian; Wang, Zhou; Huang, Zongwang; Xie, Zuyan; Xia, Lu; Zhang, Yi

doi:10.3390/ma17071691

Cited by 3 publications

(3 citation statements)

References 90 publications

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“…When applied to wound dressings, they promote flexibility, wrapping, sealing, and impermeability. Clay minerals can also prevent infections caused by environmental bacteria and prevent losses of active dressing components [76].…”

Section: Main Clays and Clay Minerals Used In The Composition Of Biof...mentioning

confidence: 99%

“…By combining clay minerals and biopolymers, biofilms can be developed using various nanofillers, which are considered promising alternatives as active compounds (as shown in Figure 4). vent infections caused by environmental bacteria and prevent losses of active dressing components [76].…”

Section: Nanofillers As Active Compoundsmentioning

confidence: 99%

“…These modern films are designed to have antioxidant and antimicrobial activity to aid in wound treatment. Furthermore, due to their physiological inertness, biocompatibility, mixed surface charge, chemical stability, adsorption capacity, and presence of surface active sites such as hydroxyl groups and silanol groups, clay minerals have healing promotion and hemostasis characteristics, making them highly suitable for incorporation into films based on biopolymers for wound management [76].…”

Section: Wound Dressingmentioning

confidence: 99%

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Clay Minerals and Biopolymers in Film Design: Overview of Properties and Applications

Trigueiro,

Pereira,

Ferreira

et al. 2024

Minerals

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Research to replace petroleum-based plastics has been quite challenging. Currently, there is a lot of interest in biopolymers as an alternative. However, biopolymers do not have suitable mechanical properties when in film form, which limits their applications. To resolve this issue, clay minerals are being incorporated as a strategy. Clay minerals offer the films good barrier, thermal, rheological, optical, and mechanical properties. They can also work with other additives to promote antioxidant and antimicrobial activity. This brief review focuses on incorporating clay minerals with other nanofillers and bioactives to improve their physical, chemical, and functional characteristics. The synergy of these materials gives the films exceptional properties and makes them suitable for applications such as food coatings, packaging materials, dressings, and bandages for treating skin wounds.

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Section: Main Clays and Clay Minerals Used In The Composition Of Biof...mentioning

confidence: 99%

Section: Nanofillers As Active Compoundsmentioning

confidence: 99%

Section: Wound Dressingmentioning

confidence: 99%

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Clay Minerals and Biopolymers in Film Design: Overview of Properties and Applications

Trigueiro,

Pereira,

Ferreira

et al. 2024

Minerals

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Antimicrobial Mixture Based on Micronized Kaolinite and Ziziphora Essential Oil as a Promising Formulation for the Management of Infected Wounds

Karaubayeva,

Bekezhanova,

Zhaparkulova

et al. 2024

IJMS

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Kaolinite stands out as a promising natural geomaterial for developing new therapeutic systems aimed at addressing global health challenges, such as multidrug-resistant infections. In this study, we report on the formulation and biological activity of a therapeutic mixture composed of white micronized kaolinite (KAO) and Ziziphora essential oil (ZEO), intended for topical application on infected wounds. GC–MS analysis revealed that the primary component of ZEO is pulegone, constituting 72.98% of the oil. ZEO demonstrated good bioactivity against bacterial and fungal strains (MIC 1.25–5 mg/mL). Additionally, ZEO at a concentration of 0.0156% (0.156 mg/mL) was found to significantly stimulate collagen synthesis. The antimicrobial activity of the tested KAO–ZEO mixture formulation (30% KAO/0.25% ZEO in an excipient base) showed the highest effectiveness against Candida spp. (MIC 0.08–25 mg/mL) and Gram-positive bacteria (MIC 0.16–25 mg/mL), with lower activity against Gram-negative bacteria (MIC 25–50 mg/mL). Moreover, the KAO–ZEO mixture was nontoxic (cell viability near 100%) to human skin fibroblasts according to the ISO 10993-5 standard and promoted collagen synthesis by skin cells. This is the first documented formulation combining KAO and ZEO, demonstrating significant antimicrobial properties along with the ability to stimulate collagen production in fibroblasts. These properties highlight KAO–ZEO as a promising novel treatment, which may synergize with current care standards and improve wound healing outcomes.

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Development of Halloysite Nanohybrids-Based Films: Enhancing Mechanical and Hydrophilic Properties for Wound Healing

Rodríguez Pozo,

Ianev,

Martínez Rodríguez

et al. 2024

Pharmaceutics

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Most of the therapeutic systems developed for managing chronic skin wounds lack adequate mechanical and hydration properties, primarily because they rely on a single component. This study addresses this issue by combining organic and inorganic materials to obtain hybrid films with enhanced mechanical behavior, adhesion, and fluid absorption properties. To that aim, chitosan/hydrolyzed collagen blends were mixed with halloysite/antimicrobial nanohybrids at 10% and 20% (w/w) using glycerin or glycerin/polyethylene glycol-1500 as plasticizers. The films were characterized through the use of Fourier-transform infrared (FTIR) spectroscopy, thermogravimetric analysis (TGA), and electron microscopy. The mechanical properties were evaluated macroscopically using tensile tests, and at a nanoscale through atomic force microscopy (AFM) and nanoindentation. Thermodynamic studies were conducted to assess their hydrophilic or hydrophobic character. Additionally, in vitro cytocompatibility tests were performed on human keratinocytes. Results from FTIR, TGA, AFM and electron microscopy confirmed the hybrid nature of the films. Both tensile tests and nanomechanical measurements postulated that the nanohybrids improved the films’ toughness and adhesion and optimized the nanoindentation properties. All nanohybrid-loaded films were hydrophilic and non-cytotoxic, showcasing their potential for skin wound applications given their enhanced performance at the macro- and nanoscale.

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Clays and Wound Healing

Cited by 3 publications

References 90 publications

Clay Minerals and Biopolymers in Film Design: Overview of Properties and Applications

Clay Minerals and Biopolymers in Film Design: Overview of Properties and Applications

Antimicrobial Mixture Based on Micronized Kaolinite and Ziziphora Essential Oil as a Promising Formulation for the Management of Infected Wounds

Development of Halloysite Nanohybrids-Based Films: Enhancing Mechanical and Hydrophilic Properties for Wound Healing

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