A focus on zoonotic urbanisation challenges existing conceptions of global urbanism. In this article I consider how a modified urban political ecology framework might help to illuminate emerging landscapes of epidemiological risk. I show how a multi-scalar perspective on urban epidemiology, including the impact of colonialism, global capitalism, and changing relations with non-human others, unsettles existing analytical approaches. I contrast resilience-oriented public health paradigms, focused on the malleability of nature, with a historically grounded set of insights into global environmental change. I suggest that the conceptual field of zoonotic urbanisation provides an analytical entry point for understanding an emergent ‘triple crisis’ spanning climate change, biodiversity loss, and global health threats.