Clear Cell Acanthoma of the Areola and Nipple

Clear Cell Acanthoma on the Areola

“…CCA of the nipple or areola is a very rare finding, to our knowledge previously reported in only 10 patients [2,5]. All but one of the cases were in women and predominantly occurred within the second to third decade of life.…”

“…Lesions are usually solitary but may be multiple. A linear, vascular component of CCA may be seen on dermatoscopic exam, potentially aiding clinical diagnosis and explaining why CCA is prone to bleed after minimal trauma [2][3][4]. Whereas no gender or racial predilection has been observed [3], CCA of the nipple or areola is a very rare finding that has been reported primarily in young Korean women.…”

“…CCA typically presents as an asymptomatic, slowgrowing, well-demarcated pink to red papule or nodule 5-20mm in size [1]. Variable morphologies, have been described, including polypoid, pigmented, giant, and cystic forms [1,2]. Lesions are usually solitary but may be multiple.…”

Eczematous, Pruritic, Brownish Plaque of the Nipple and Areola: A Quiz

“…CCA of the nipple or areola is a very rare finding. To date, CCA seems to have been reported in no more than 12 patients, with 5 cases from Korea, 2 from the Philippines, 2 from Brazil, 1 from Spain, 1 from Italy and 1 from Cuba (4)(5)(6)(7)(8)(9). Only one male case has been described (9).…”

“…Although CCA is considered a benign lesion, appropriate treatment may be required to stop its progressive growth. No recurrences were observed with surgical resection and cryotherapy (8). Only 4 cases were reported to show remission with topical corticosteroids (7).…”