Clear Cell Adenocarcinoma Arising From Adenomyosis

Hirabayashi, Kenichi; Yasuda, Masanori; Kajiwara, Hiroshi; Nakamura, Naoya; Satō, Shigeru; Nishijima, Yoshihiro; Mikami, Mikio; Osamura, R. Yoshiyuki

doi:10.1097/pgp.0b013e31818e101f

Cited by 20 publications

(10 citation statements)

References 13 publications

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“…The most frequent histologic type of malignant neoplasm arising from adenomyosis is endometrioid adenocarcinoma. However, until recently, only 2 cases of clear cell carcinoma (CCA) arising from adenomyosis has been reported [2,4]. Here, we report additional one case of CCA arising from adenomyosis clinically mimicking smooth muscle tumor of myometrium.…”

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confidence: 88%

Clear cell adenocarcinoma arising from adenomyosis mimicking leiomyoma: A case report

Shin

Cho

Sung

et al. 2011

Korean J Obstet Gynecol

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The incidence of cancer from adenomyosis is rare. Previously, only two cases of clear cell adenocarcinoma (CCA) arising from adenomyosis have been reported in English literature. Here, we report a case of CCA arising from adenomyosis. A 52-year-old postmenopausal Korean woman presented with complaints of vaginal bleeding and back pain. Endometrial biopsy revealed endometrial polyp with atrophic change and transvaginal ultrasonography showed myomas with cystic change. Magnetic resonance imaging revealed a cystic degenerative mass consistent with leiomyoma in the posterior portion of uterus body. And the serum level of CA-125 was 17.7 U/mL. Hysterectomy revealed a yellow-ten solid mass in the myometrium that was diagnosed as CCA arising from adenomyosis. The tumor was mainly located in the myometrium and transition between adenomyosis and CCA along with endometrial stromal cell was identifi ed. Malignant tumor arising from adenomyosis could be considered as a differential diagnosis when the patient with adenomyosis and intact endometrial surface complained of vaginal bleeding.

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confidence: 88%

Clear cell adenocarcinoma arising from adenomyosis mimicking leiomyoma: A case report

Shin

Cho

Sung

et al. 2011

Korean J Obstet Gynecol

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“…EIC as a putative precursor of SEA also may develop into CCA . Even though rarely encountered, CCA may arise from adenomyosis and from endometrial polyps …”

Section: Conventional/prototypic Featuresmentioning

confidence: 99%

Immunohistochemical characterization of endometrial carcinomas: Endometrioid, serous and clear cell adenocarcinomas in association with genetic analysis

Yasuda

2014

J of Obstet and Gynaecol

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Developments in immunohistochemistry, which are closely linked with the advances in the analyses of genetic abnormalities and their associated molecular disorders as early and late histogenetic events, have contributed greatly to the improvement of pathological diagnostic confirmation and validation. Immunohistochemistry has also generated great benefit to the innovation of therapeutic strategies for various kinds of cancers. In this article, the three representative histological types of corpus cancer, namely, endometrioid adenocarcinoma, serous adenocarcinoma and clear cell adenocarcinoma, will be histologically approached in association with their immunohistochemical profiles as well as genetic disorders. First, the focus will be on 'Conventional/ prototypic features,' followed by 'Controversy over conventional histological subclassification,' and subsequently 'Tumorigenesis and re-subclassification.'

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“…In view of this, the current adenosarcoma is likely to be overstaged when using a staging system that does not take into account adenosarcomas that arise ab initio within the outer half of the myometrium (and are confined to this layer). The same situation arises when uterine adenocarcinoma arises in endometriosis or adenomyosis, 14,15 and there is no evidence of carcinoma in the eutopic endometrium.…”

Section: Discussionmentioning

confidence: 95%

Müllerian Adenosarcoma Arising in a Subserosal Adenomyoma

et al. 2012

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Müllerian adenosarcomas most commonly arise in the uterine corpus from the eutopic endometrium. Occasionally, they arise in the cervix, vagina, broad and round ligaments, and ovaries and rarely in extragenital sites, usually in association with endometriosis. The authors report a rare case of extraendometrial, intramural adenosarcoma of low grade arising from a subserosal adenomyoma in a 46-year-old woman who presented with vaginal bleeding. No evidence of eutopic endometrial origin was identified; the adenosarcoma showed only limited myometrial invasion and no serosal involvement. Because of its subserosal location, the tumor would be overstaged as IC (deeply myoinvasive) in the new FIGO staging system. Stage IC tumors would normally be considered for adjuvant treatment, which would be inappropriate in this case. To avoid overstaging and inappropriate treatment, it is important to recognize that adenosarcoma can, rarely, arise in adenomyomas (or adenomyosis).

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Clear Cell Adenocarcinoma Arising From Adenomyosis

Cited by 20 publications

References 13 publications

Clear cell adenocarcinoma arising from adenomyosis mimicking leiomyoma: A case report

Clear cell adenocarcinoma arising from adenomyosis mimicking leiomyoma: A case report

Immunohistochemical characterization of endometrial carcinomas: Endometrioid, serous and clear cell adenocarcinomas in association with genetic analysis

Müllerian Adenosarcoma Arising in a Subserosal Adenomyoma

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