Clear Cell Adenocarcinoma Arising in an Adenomyoma of the Broad Ligament

Torres, Diogo; Parker, Lynn P.; Moghadamfalahi, Mana; Sanders, Mary Ann; Metzinger, Daniel S.

doi:10.1177/1066896914539550

Cited by 9 publications

(16 citation statements)

References 23 publications

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“…[ 43 ] 3 cm, left round ligament 49 Metromenorrhagia CT inguinal adenopathy TAH with BSO and lymph node dissection M 27 Torres et al. [ 44 ] 4 cm, right broad ligament 58 Post menopausal bleeding USG,CT malignancy Total Robotic hysterectomy with bilateral salpingo- oophorectomy M 28 Sopha et al. [ 45 ] 1.4 cm, liver 47 RSO for teratoma, SCH + HRT Right quadrant and back pain CT Laparoscopic excision biopsy S, B 29 Ko et al.…”

Section: Discussionmentioning

confidence: 99%

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A rare case of ovarian adenomyoma mimicking primary invasive ovarian cancer with a contralateral serous borderline ovarian tumor: A case report and review of the literature

Liberale

Surace

Lilleri

et al. 2020

Heliyon

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Extrauterine adenomyoma is a rare type of benign tumor, characterized by nodular aggregate of smooth muscle, endometrial glands and endometrial stroma, arising outside the uterus. In this study we describe a case of primary ovarian adenomyoma associated with endometriotic cysts with contralateral serous borderline tumor in a 40-year-old woman and we highlight how preoperative exams could lead to the suspicious of invasive cancer. We provide a review of the literature, analyzing all cases of extrauterine adenomyoma published so far, classifying them on the basis of pathogenetic theories proposed, localization of the lesion, imaging modalities and treatment adopted.

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Section: Discussionmentioning

confidence: 99%

“…Torres et al. [ 44 ] reported clear cell adenocarcinoma in a case of broad ligament adenomyoma. Ulm et al.…”

Section: Discussionmentioning

confidence: 99%

A rare case of ovarian adenomyoma mimicking primary invasive ovarian cancer with a contralateral serous borderline ovarian tumor: A case report and review of the literature

Liberale

Surace

Lilleri

et al. 2020

Heliyon

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“…Similar lesions were described in the small intestine [101] and the nervous system [102]. Extrauterine adenomyomas may arise from the ovary [103], the ovarian ligament [104], the broad ligament [105] or the round ligament [106] and are not connected to the uterus. Rokitansky's early description may be an instance of an adenomyomatous polyp [21].…”

Section: Müllerianosis and Mixed Endometrial-myometrial Lesionsmentioning

confidence: 64%

The History of the Discovery of Ectopic Epithelial Cells in Lower Peritoneal Organs: The So-Called Mucosal Invasion

2021

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Through microscopy, early researchers identified the epithelium on the inner surfaces of the uterus, cervix and Fallopian tubes. The identification of ectopic epithelium was gradual, starting from the gross pathology study of unusual cystic lesions. Towards the end of the nineteenth century, attention focused on the epithelium as a critical component. The term ‘adenomyoma’ was coined around eighteen eighty to designate the majority of mucosa-containing lesions. Several theories were advanced to explain its aetiology. In the main, lesions were considered to arise from invasion from uterine epithelium; implantation of endometrium through retrograde menstruation; hematogenous or lymphatic spread; or from embryonic remnants. Although initially widely rejected, around 1920, an almost unanimous consensus formed on the endometrial nature of epithelial invasions. During the following years, adenomyosis and endometriosis came to be used to distinguished lesions within or outside the uterus. Adenomyosis was attributed to direct infiltration of uterine mucosa into the myometrium, and endometriosis to the implantation of endometrial cells and stroma into the peritoneal cavity through retrograde menstruation. Around the same time, ovarian lesions, initially described as ovarian hematomas or chocolate cysts, were regarded as a form of endometriosis. Three variants of endometriosis were thus described: superficial peritoneal, deep nodular and ovarian endometriomas. Ectopic epithelium has long been recognised as having similarities to tubal, or cervical epithelium. Lesions containing mixed epithelium are often termed Müllerianosis. This article demonstrates the stepwise evolution of knowledge, the role of the pioneers and the difficulties that needed to be overcome. It also demonstrates the value of collaboration and the inter-connected nature of the scientific endeavour.

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“…However, most authors advice adjuvant platinum-based chemotherapy (paclitaxel and carboplatin). 2,[14][15][16] In the present case, as the peritoneal cytology was positive for malignancy, the patient was planned for carboplatin and paclitaxel chemotherapy. This was followed by hormonal therapy because of the nuclear positivity for ER and PR.…”

Section: Discussionmentioning

confidence: 80%

“…The exact role of the postsurgical treatment is not a consensus. Surgery alone, 6,10 surgery followed by chemotherapy 5,7,11,[13][14][15][16] and/or radiotherapy 5,6,9 have been used for treating primary broad ligament carcinoma. However, most authors advice adjuvant platinum-based chemotherapy (paclitaxel and carboplatin).…”

Section: Discussionmentioning

confidence: 99%

Primary broad ligament adenocarcinoma

et al. 2020

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Primary broad ligament carcinoma is a very rare occurrence with 28 reported cases worldwide, to date. The epidemiology, treatment strategy and prognosis are still uncertain because of the scarcity of cases. Currently, all broad ligament carcinomas are managed similar to epithelial ovarian cancer. We report the case of a 43-year-old female with a prolonged complaint of abdominal pain and intermittent urinary retention, requiring frequent catheterization. She was diagnosed with obstructive right hydroureteronephrosis. The abdominal Contrast Enhanced Computed Tomography (CECT) revealed a well-defined heterogeneous lesion of 2.1х3х3.2cm size in the right lateral and posterior wall of the cervix. An ultrasound (USG)-guided Fine Needle Aspiration Cytology (FNAC) of the mass was done and it was suspected to be malignant. The patient underwent total abdominal hysterectomy, right salpingo-oophorectomy, pelvic lymph-nodal sampling, and peritoneal washing. Histological examination depicted an endometrioid adenocarcinoma of the broad ligament. She received adjuvant chemotherapy, followed by hormonal therapy. It has been five years since her surgery, and she is now alive and disease free.

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Clear Cell Adenocarcinoma Arising in an Adenomyoma of the Broad Ligament

Cited by 9 publications

References 23 publications

A rare case of ovarian adenomyoma mimicking primary invasive ovarian cancer with a contralateral serous borderline ovarian tumor: A case report and review of the literature

A rare case of ovarian adenomyoma mimicking primary invasive ovarian cancer with a contralateral serous borderline ovarian tumor: A case report and review of the literature

The History of the Discovery of Ectopic Epithelial Cells in Lower Peritoneal Organs: The So-Called Mucosal Invasion

Primary broad ligament adenocarcinoma

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