Clear Cell Adenocarcinoma of the Colon Arising in the Background of Endometriosis: A Case Report and Diagnostic Approach

Finkelstein, Alexander; Levy, Gillian H.; Hui, Pei

doi:10.1309/lmjctyeh9s22vqxw

Cited by 7 publications

(13 citation statements)

References 13 publications

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“…Its true incidence and prevalence remain unknown. In a study published in 1999, out of 3,486 cases of colon cancer, only 3 (0.086%) were reported having clear cell variant [ 2 – 5 ]. There are no newer similar studies.…”

Section: Discussionmentioning

confidence: 99%

“…The clear-aspect origin of these cells is still unknown; while some authors argue that the clear appearance of the cell comes from glycogen accumulation [ 6 ], some others failed to demonstrate this [ 3 ]. Most commonly, clear cell adenocarcinomas originate from the kidneys and Müllerian organs, such as the uterus, fallopian tubes, and ovaries [ 5 ]. Some cases of endometriotic dysplastic glands with clear cell changes in the colon have been reported, and they are known as endometriosis-associated intestinal tumors (EAIT) [ 5 ].…”

Section: Discussionmentioning

confidence: 99%

“…Most commonly, clear cell adenocarcinomas originate from the kidneys and Müllerian organs, such as the uterus, fallopian tubes, and ovaries [ 5 ]. Some cases of endometriotic dysplastic glands with clear cell changes in the colon have been reported, and they are known as endometriosis-associated intestinal tumors (EAIT) [ 5 ]. According to our review, males are most commonly affected than females, usually between the 6th and 7th decades of life, and the primary lesion most commonly involves the left colon [ 2 – 4 , 7 , 8 ].…”

Section: Discussionmentioning

confidence: 99%

“…According to current literature, one way to differentiate a primary intestinal neoplasia from a Müllerian neoplasia is with cytokeratins [ 3 – 5 , 10 – 14 ]. Cytokeratins (CK) are composed of at least 20 structural proteins of epithelial cells and their patterns of expression vary depending on the location of the epithelium.…”

Section: Discussionmentioning

confidence: 99%

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Clear Cell Adenocarcinoma of the Colon: A Case Report and Review of the Literature

Barrera-Maldonado

Wiener²,

Sim

2014

Case Reports in Oncological Medicine

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Clear cell adenocarcinoma of the colon has been described scarcely in the literature. It affects elderly men more commonly than women and usually appears in the left side of the colon. A Hispanic 41-year-old female came to the emergency room with abdominal pain, vomiting, and distension. Physical exam revealed generalized tenderness without peritoneal signs. Laboratory data was unremarkable. A CT scan showed an apple-core lesion in the distal colon. A flexible sigmoidoscopy revealed an obstructive mass that made further evaluation impossible. Exploratory surgery revealed a hard mass obstructing the descending colon, which was resected. Histopathology analysis with immunohistochemistry staining was positive for cytokeratin 20, cytokeratin 10, CDX2, and villin, while it was negative for cytokeratin 7, RCC, vimentin, and CD31. These results confirmed the clear cell variant of the adenocarcinoma. Clear cell adenocarcinomas usually arise from the kidneys and Müllerian organs. Immunohistochemistry is crucial for establishing the origin of these neoplastic cells. A cytokeratin 20+/7− with positive CDX2 is highly specific and sensitive for intestinal neoplastic origin. The main treatment has been surgery alone with moderately good results. More research and information about this malignancy is needed, especially in regard to prognosis and in order to provide the best treatment option.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Clear Cell Adenocarcinoma of the Colon: A Case Report and Review of the Literature

Barrera-Maldonado

Wiener²,

Sim

2014

Case Reports in Oncological Medicine

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“…Surgery has been the main treatment in all reported cases. There are some cases in which adjuvant chemotherapy has been used, but there are no reports or studies addressing the usefulness, superiority, or inferiority of chemo-or radiotherapy [10,11]. For CCA developed within attenuated AFP, with synchronous conventional intestinal type adenocarcinomas, prognosis corresponds to that of the conventional adenocarcinoma in the setting of attenuated AFP.…”

Section: Discussionmentioning

confidence: 99%

Clear Cell Adenocarcinoma of the Colon in the Setting of Attenuated Familial Polyposis: A Rare Variant of Primary Colonic Adenocarcinoma

Mhamdi¹,

Bdioui²,

Abdessayed³

et al. 2017

Next Generat Sequenc & Applic

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Clear cell adenocarcinoma of the colon has been described rarely in the literature. It affects more commonly elderly men and usually appears in the left side of the colon. A 52-year-old male with a past medical history of attenuated FAP, who was diagnosed during a routine colonoscopy with bifocal tumor associated to 2 polyps of the transverse colon. Physical exam was normal. Laboratory data was unremarkable. A total colectomy with ileo-rectal anastomosis was performed. Gross examination of surgical specimen revealed 3 tumors and 6 pedicaulated polyps. Histopathology analysis of both coecal tumors conclude to an intestinal type adenocarcinoma.However, for the third one located in the left colon was histologically different displaying clear cell features. The later showed at immunohistochemistry study a positive staining for CK20, CDX2, while it was negative for CK 7 and CD 10. These results confirmed the clear cell variant of the adenocarcinoma. Clear cell adenocarcinomas usually arises from kidneys and Mûllerian organs. Colorectal occurrence is rare especially in the setting of attenuated adenomatous polyposis. More research and information about this malignancy is needed, especially in regard to prognosis and in order to provide the best treatment option.

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Müllerian clear cell carcinoma arising from rectal endometriosis with pericolonic lymph node metastasis

Lochner,

Nakayama,

Steinhagen

et al. 2024

Virchows Arch

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Clear Cell Adenocarcinoma of the Colon Arising in the Background of Endometriosis: A Case Report and Diagnostic Approach

Cited by 7 publications

References 13 publications

Clear Cell Adenocarcinoma of the Colon: A Case Report and Review of the Literature

Clear Cell Adenocarcinoma of the Colon: A Case Report and Review of the Literature

Clear Cell Adenocarcinoma of the Colon in the Setting of Attenuated Familial Polyposis: A Rare Variant of Primary Colonic Adenocarcinoma

Müllerian clear cell carcinoma arising from rectal endometriosis with pericolonic lymph node metastasis

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