Clear cell adenocarcinoma of the bladder with intravesical cervical invasion

Marchalik, Daniel; Krishnan, Jayashree; Verghese, Mohan; Venkatesan, Krishnan

doi:10.1136/bcr-2015-209893

Cited by 2 publications

(1 citation statement)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The present tumor is highly likely to be adenocarcinoma because of the presence of focal gland formations and mucin. [1][2][3] However, the histology resembles RCC, HCC, prostatic adenocarcinoma, and clear cell malignancies of other primary sites. The present case is apparently different from papillary urothelial neoplasma and inverted papilloma.…”

Section: Discussionmentioning

confidence: 99%

Clear cell adenocarcinoma of bladder expressing prostate-specific antigen, alpha-methylacyl-CoA racemase and CD10

Terada

2016

CRCP

View full text Add to dashboard Cite

Backgrounds: Clear cell adenocarcinoma (CCA) of urinary bladder (UB) is rare. Aims: To report a case of CCA of UB immunohistochemically expressing prostate-specific antigen (PSA), alpha-methylacyl-CoA racemase (AMACR) and CD10; thus this case was difficult to differentiate from metastasis from prostatic adenocarcinoma or renal cell carcinoma (RCC). Case: An 84-year-old man presented with dysuria and hematuria, and cystoscopy revealed a bladder tumor. The biopsy showed proliferation and invasion (more than pT2) of high-grade carcinoma cells focally forming glandular structures. Lymphovascular permeations were recognized. Focally, usual urothelial carcinoma (UC) was seen and there were gradual direct transitions between the clear cell carcinoma and UC. Immunohistochemically, the carcinoma cells were positive for PSA, AMACR, CD10, p53, Ki67 (labeling = 10%), uroplakin II, thrombomodulin, and cytokeratin (CK) 20, but negative for Hepatocyte-paraffin1 (HepPar1), CK7, PAX8, and TTF-1. Conclusions: A rare case of CCA of UB with immunoexpressions of PSA, AMACR and CD10 is reported. The aberrant expressions of these three antigens are only speculative. The gradual transitions between UC and CCA and the presence of urothelial antigens in this tumor suggest that the tumor might have originated from UC.

show abstract

Section: Discussionmentioning

confidence: 99%