Clear cell adenocarcinoma of the colon is a unique morphologic variant of intestinal carcinoma: A rare case report

Bakshi, Neha; Sharma, Saurabh; Kaushal, Vijay; Mardi, Kavita

doi:10.4103/2278-0513.102901

Cited by 7 publications

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“…There are no newer similar studies. The clear-aspect origin of these cells is still unknown; while some authors argue that the clear appearance of the cell comes from glycogen accumulation [ 6 ], some others failed to demonstrate this [ 3 ]. Most commonly, clear cell adenocarcinomas originate from the kidneys and Müllerian organs, such as the uterus, fallopian tubes, and ovaries [ 5 ].…”

Section: Discussionmentioning

confidence: 99%

“…According to our review, males are most commonly affected than females, usually between the 6th and 7th decades of life, and the primary lesion most commonly involves the left colon [ 2 – 4 , 7 , 8 ]. Some authors have suggested and found a carcinogenic progression from adenoma to clear cell change adenoma and clear cell adenocarcinoma [ 3 , 4 , 8 , 9 ]. However, because of the negative past history and the acute presentation of our patient, it was impossible to determine this sequence.…”

Section: Discussionmentioning

confidence: 99%

“…According to current literature, one way to differentiate a primary intestinal neoplasia from a Müllerian neoplasia is with cytokeratins [ 3 – 5 , 10 – 14 ]. Cytokeratins (CK) are composed of at least 20 structural proteins of epithelial cells and their patterns of expression vary depending on the location of the epithelium.…”

Section: Discussionmentioning

confidence: 99%

“…CK7 is a type II keratin usually found in nonkeratinizing epithelia with a molecular weight of 54 kDa [ 4 ]. A positive CK20 and a negative CK7 would indicate an intestinal origin of the neoplasia with great accuracy because CK20 is usually expressed in the intestinal and gastric epithelium and the endocrine cells in the upper portions of the pyloric glands, whereas CK7 is usually found in the breast, lung, ovary, and urothelium [ 3 – 5 , 11 , 15 ]. CDX2 is another marker available for intestinal neoplasia [ 12 – 14 ].…”

Section: Discussionmentioning

confidence: 99%

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Clear Cell Adenocarcinoma of the Colon: A Case Report and Review of the Literature

Barrera-Maldonado

Wiener²,

Sim

2014

Case Reports in Oncological Medicine

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Clear cell adenocarcinoma of the colon has been described scarcely in the literature. It affects elderly men more commonly than women and usually appears in the left side of the colon. A Hispanic 41-year-old female came to the emergency room with abdominal pain, vomiting, and distension. Physical exam revealed generalized tenderness without peritoneal signs. Laboratory data was unremarkable. A CT scan showed an apple-core lesion in the distal colon. A flexible sigmoidoscopy revealed an obstructive mass that made further evaluation impossible. Exploratory surgery revealed a hard mass obstructing the descending colon, which was resected. Histopathology analysis with immunohistochemistry staining was positive for cytokeratin 20, cytokeratin 10, CDX2, and villin, while it was negative for cytokeratin 7, RCC, vimentin, and CD31. These results confirmed the clear cell variant of the adenocarcinoma. Clear cell adenocarcinomas usually arise from the kidneys and Müllerian organs. Immunohistochemistry is crucial for establishing the origin of these neoplastic cells. A cytokeratin 20+/7− with positive CDX2 is highly specific and sensitive for intestinal neoplastic origin. The main treatment has been surgery alone with moderately good results. More research and information about this malignancy is needed, especially in regard to prognosis and in order to provide the best treatment option.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Clear Cell Adenocarcinoma of the Colon: A Case Report and Review of the Literature

Barrera-Maldonado

Wiener²,

Sim

2014

Case Reports in Oncological Medicine

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“…There are currently two types of CCCs; the intestinal type and the Müllerian type. Three diagnostic criteria are necessary to retain the intestinal type: the presence of colonic adenoma near the tumor or a composite tumor with a classic adenocarcinoma component, the absence of endometriotic lesions, and immunohistochemical expression of intestinal differentiation (CEA, CK20, CDX-2) [ 1 , 6 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 ].…”

Section: Discussionmentioning

confidence: 99%

Right Colon Clear Cell Carcinoma of Müllerian Type

Khefacha¹,

Triki²,

Ayed³

et al. 2022

Case Rep Gastroenterol

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Clear cell carcinoma (CCC) is usually seen in tissues originating from the paramesonephric (Müllerian) ducts such as the kidneys, the ovaries, the cervix and the vagina. The pathogenesis has not yet been elucidated. The diagnostic hallmark is the clear cytoplasm. Primitive CCC of the colon is a very rare entity. There are two types of CCC of the colon; the intestinal type and the Müllerien type. The differential diagnosis arises mainly with secondary metastases of renal or ovarian origin. Immunohistochemistry allows retaining the primitive character. The treatment is not yet consensual. It depends on the type of tumor and its stage. The treatment is based on surgery and possibly chemotherapy. We report the case of a 75-year-old female patient who underwent surgery for a tumor of the ascending colon. Microscopic examination concluded an extensively necrotic carcinomatous growth which infiltrated all the layers of the intestinal wall and the peritoneum. The tumor was made of clusters and spans of clear cells which were separated by thin conjunctivo-vascular septa. The tumor cells were round to polygonal with a clear, optically empty, pseudo-vegetative (physaliferous) cytoplasm. Immunohistochemistry study showed a positive staining with CK7 and a negative staining with CK20, CDX2, PAX8, P63, CD10, chromogranin, and synaptophysin. We performed a Medical Literature databases (Pubmed and Google Scholar) research. Only forty-two cases were reported in English literature. The main age is 55.7 (25–89). The sex ratio is one, but female cases were younger (52 vs. 61). The rectum is the most involved site. The left colon location is more frequent than the right one. The Müllerian type was found only at the level of the left colon and rectum. There was no CCC in the right colon of Müllerien type. The case we report herein is the first right colon CCC which is positive in CK7 staining.

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Early stage clear cell adenocarcinoma of the colon examined in detail with image-enhanced endoscopy: a case report

Tochio¹,

Mukai²,

Baba³

et al. 2018

Clin J Gastroenterol

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Clear cell adenocarcinoma of the colon is a unique morphologic variant of intestinal carcinoma: A rare case report

Cited by 7 publications

References 0 publications

Clear Cell Adenocarcinoma of the Colon: A Case Report and Review of the Literature

Clear Cell Adenocarcinoma of the Colon: A Case Report and Review of the Literature

Right Colon Clear Cell Carcinoma of Müllerian Type

Early stage clear cell adenocarcinoma of the colon examined in detail with image-enhanced endoscopy: a case report

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