Clear cell adenocarcinoma of the uterine cervix arising from a background of cervical endometriosis

Hiromura, Tadao; Tanaka, Yumiko; Nishioka, Takeshi; Satoh, Masayuki; Tomita, Kazuhiko

doi:10.1259/bjr/75304693

Cited by 38 publications

(28 citation statements)

References 10 publications

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“…Genomic instability is suggested as a mechanism of DES-related carcinogenesis. 45,46 Diagnosis Vaginal bleeding is the most frequent initial symptom. The accuracy of cervical cytology in the diagnosis of CCAC is low.…”

Section: Molecular Biology and Geneticsmentioning

confidence: 99%

Gynecologic Cancer InterGroup (GCIG) Consensus Review for Clear Cell Carcinoma of the Uterine Corpus and Cervix

Hasegawa

Nagao

Yasuda

et al. 2014

Int J Gynecol Cancer

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Clear cell carcinomas of the uterine corpus and cervix are rare gynecological cancers with limited information regarding the pathogenesis and biology. At present, the approach to management is the same as for patients with the more common histological subtypes of endometrioid endometrial cancer and adenocarcinoma of the cervix. Surgical resection is the standard treatment for patients with early-stage disease, but there is no evidence-based approach to direct the management of patients with more advanced-stage disease at presentation or with recurrent disease. We review the epidemiology, pathology, and what is known about both uterine corpus and cervical clear cell cancers and make management recommendations.

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Section: Molecular Biology and Geneticsmentioning

confidence: 99%

Gynecologic Cancer InterGroup (GCIG) Consensus Review for Clear Cell Carcinoma of the Uterine Corpus and Cervix

Hasegawa

Nagao

Yasuda

et al. 2014

Int J Gynecol Cancer

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“…The common symptom is generally irregular vaginal bleeding and the majority of patients (80%) in the series presented with this symptom. The tumor growth is endophytic and tend to show deep infiltration of the cervix and also extend to the uterine corpus more often than other cervical carcinomas [9]. It is histologically characterized by a mixture of clear and hobnail shaped tumor cells arranged in solid masses and papillary tubule [1].…”

Section: Discussionmentioning

confidence: 99%

“…Early-stage CCCCs have a favourable prognosis and retrospective review has shown that patients with early stage disease are amenable to surgery and have a good overall survival. This review also discussed that CCCC patients with bulky tumor, more than half stromal infiltration, positive lymph nodes are at higher risk of recurrence and would appear to benefit from chemo-radiation [8,9]. The prognosis of patients with early stage CCCC treated surgically and noted to be free of lymphatic dissemination is excellent irrespective of the use of adjuvant therapy.…”

Section: Discussionmentioning

confidence: 99%

Clear Cell Carcinoma of the Uterine Cervix: A Case Series of Five Patients

Ds¹,

Rd²

2013

JCR

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In view of histopathological revelation of the parametrium involvement, two postoperative patients received adjuvant radiotherapy while three patients received radical concurrent chemo-radiotherapy along with weekly cisplatin. On a follow up of 5 years, one patient showed progressive disease and died after 27 month, one patient defaulted follow up and the remaining three patients had no relapse or metastasis and are on routine follow up. Conclusion: Primary clear cell carcinoma of uterine cervix is a rare disease where patients with low risk early stage may be managed with radical surgery alone, with or without the need for adjuvant chemotherapy or radiation. Advanced stage CCCC should be treated with a combination of platinum based chemoradiotherapy

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“…Genital endometriosis is a rare condition, but it has the potential to occur at several sites and should not be excluded from a number of differential diagnoses [21]. Diagnosis can be misinterpreted as a neoplasm and can be missed entirely in other cases.…”

Section: Discussionmentioning

confidence: 99%

Fine Needle Aspiration Cytology: A Tool to Diagnose Cervical and Vaginal Endometriosis in Low-Income Places

Oliveira-Filho

Rao²,

Eleutério³

et al. 2013

Acta Cytologica

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Regarded as infrequent, vaginal and cervical endometriosis is probably more common than is generally realized. The apparent rarity of the lesion may be ascribed to the limited awareness of its clinical appearance, combined with technical difficulty in obtaining suitable biopsy material for confirmation. Thus, clinical recognition and tissue confirmation become essential. This paper focuses on vaginal and cervical endometriosis, documenting the clinical, macroscopic, cytological and colposcopic findings in 4 cases seen at a single physical vaginal examination. Diagnosis in these patients was facilitated and improved by fine needle aspiration cytology and confirmed by histology. This technique, which is not used for the diagnosis of endometriosis, could be an option in low-income areas.

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Clear cell adenocarcinoma of the uterine cervix arising from a background of cervical endometriosis

Cited by 38 publications

References 10 publications

Gynecologic Cancer InterGroup (GCIG) Consensus Review for Clear Cell Carcinoma of the Uterine Corpus and Cervix

Gynecologic Cancer InterGroup (GCIG) Consensus Review for Clear Cell Carcinoma of the Uterine Corpus and Cervix

Clear Cell Carcinoma of the Uterine Cervix: A Case Series of Five Patients

Fine Needle Aspiration Cytology: A Tool to Diagnose Cervical and Vaginal Endometriosis in Low-Income Places

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