Clear cell adenocarcinoma of the colon: A case report and review of literature

Soga, Koichi; Konishi, Hideyuki; Tatsumi, Natsuko; Konishi, Chika; Nakano, Katsunori; Wakabayashi, Naoki; Mitsufuji, Shoji; Kataoka, Keisuke; Okanoue, Takeshi; Mukaisho, Ken‐ichi; Hattori, Takanori

doi:10.3748/wjg.14.1137

Cited by 20 publications

(19 citation statements)

References 19 publications

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“…Clear cell adenocarcinomas (CCAs) are very rare in the colon [1][2][3] . They generally affect elderly men, are preferentially located in the left colon and almost all form part of a larger conventional adenoma [4,5] .…”

Section: Introductionmentioning

confidence: 99%

Clear cell adenocarcinoma of the colon is a unique morphological variant of intestinal carcinoma: Case report with molecular analysis

Barisella¹,

Lampis²,

Perrone³

et al. 2008

WJG

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Here we report a new case of clear cell adenocarcinoma (CCA) of the colon in a 54-year-old Caucasian man. Despite of the previous reported cases, the lesion was located in the right colon and was not associated with the conventional adenoma. We performed immunohistochemical and molecular analyses in order to explore whether the CCA had the molecular features generally associated with conventional colorectal carcinoma. The immunohistochemical and molecular analyses showed that the different morphology of CCA does not reflect a distinct biological entity but only an unusual morphological variant of intestinal carcinoma.

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Section: Introductionmentioning

confidence: 99%

Clear cell adenocarcinoma of the colon is a unique morphological variant of intestinal carcinoma: Case report with molecular analysis

Barisella¹,

Lampis²,

Perrone³

et al. 2008

WJG

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“…The CCA affects mainly kidney and Mullerien organs [8], therefore it is necessary to distinguish primary CCA of the colon from colonic metastasis of CCA deriving from the ovary, kidney, and other organs. Clinical and histologic features are insufficient to make distinction between primary or secondary colorectal CCA and immunohistochemical study is essential.…”

Section: Discussionmentioning

confidence: 99%

Clear Cell Adenocarcinoma of the Colon in the Setting of Attenuated Familial Polyposis: A Rare Variant of Primary Colonic Adenocarcinoma

Mhamdi¹,

Bdioui²,

Abdessayed³

et al. 2017

Next Generat Sequenc & Applic

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Clear cell adenocarcinoma of the colon has been described rarely in the literature. It affects more commonly elderly men and usually appears in the left side of the colon. A 52-year-old male with a past medical history of attenuated FAP, who was diagnosed during a routine colonoscopy with bifocal tumor associated to 2 polyps of the transverse colon. Physical exam was normal. Laboratory data was unremarkable. A total colectomy with ileo-rectal anastomosis was performed. Gross examination of surgical specimen revealed 3 tumors and 6 pedicaulated polyps. Histopathology analysis of both coecal tumors conclude to an intestinal type adenocarcinoma.However, for the third one located in the left colon was histologically different displaying clear cell features. The later showed at immunohistochemistry study a positive staining for CK20, CDX2, while it was negative for CK 7 and CD 10. These results confirmed the clear cell variant of the adenocarcinoma. Clear cell adenocarcinomas usually arises from kidneys and Mûllerian organs. Colorectal occurrence is rare especially in the setting of attenuated adenomatous polyposis. More research and information about this malignancy is needed, especially in regard to prognosis and in order to provide the best treatment option.

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“…An up to date review of the English language literature identified 13 reported cases of clear cell change occurring in colonic adenoma and adenocarcinoma including the case reported here (see the table) [1][2][3][4][6][7][8][9][10][11] . Of those cases 9 of 13 (69.2%) occurred in male patients.…”

Section: Discussionmentioning

confidence: 99%

“…Five of 13 (38.5%) were diagnosed as invasive adenocarcinomas. Eight of 13 (61.5%) were treated endoscopically and the remainder were treated with surgical excision [1][2][3][4][6][7][8][9][10][11] . One retrospective study of 3486 colonic adenomas found changes in only 3 specimens (0.086%) [2] .…”

Section: Discussionmentioning

confidence: 99%

“…Glycogen is often implicated in other lesions with clear cell change but clear cell change in the colon is generally negative for glycogen granules when stained for PAS [1][2][3][6][7][8][9][10] . Clear cell lesions are also typically negative for alcian blue staining pointing to an absence of mucin in the clear cells [1][2][3][6][7][8][9][10] . Our case was negative for PAS staining granules and negative for mucin on Alcian Blue staining, consistent with previous reports.…”

Section: Discussionmentioning

confidence: 99%

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Clear cell change in colonic adenomas: case report and review of the literature

Chan

Cho

Neto

2014

CRCP

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Clear cell change is a very rare finding in colonic adenomas and adenocarcinomas. The few described cases were predominantly in elderly male patients with a predilection for the left colon and rectum. Here we present the second case of clear cell morphology in a colonic adenoma with high-grade dysplasia, occurring in the ascending colon of an elderly female patient. Immunohistochemical and special stains analyses were performed showing findings similar to prior reports of this unusual morphologic entity and excluding the possibility of other synchronous tumors or metastases to the colon with clear cell morphology. A review of primary colonic tumors with clear cell features was also performed and is discussed here.

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Clear cell adenocarcinoma of the colon: A case report and review of literature

Cited by 20 publications

References 19 publications

Clear cell adenocarcinoma of the colon is a unique morphological variant of intestinal carcinoma: Case report with molecular analysis

Clear cell adenocarcinoma of the colon is a unique morphological variant of intestinal carcinoma: Case report with molecular analysis

Clear Cell Adenocarcinoma of the Colon in the Setting of Attenuated Familial Polyposis: A Rare Variant of Primary Colonic Adenocarcinoma

Clear cell change in colonic adenomas: case report and review of the literature

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