Clear Cell Adenocarcinoma of the Bladder in a Male Patient: Clinicopathologic Analysis of a Case

Signori, G.; Tonini, Gerolamo; Aulenti, V.; Taher, Bassam; Rad, Farshid-Kalantary; Tosana, M; Ungari, Marco; Zorzi, Fausto

doi:10.1159/000071856

Cited by 9 publications

(5 citation statements)

References 7 publications

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“…Signori et al [ 22 ] reported a case of clear cell adenocarcinoma of the urinary bladder in 54-year-old man. He underwent cystoscopy which revealed a tumour arising from the dome of his urinary bladder.…”

Section: Discussion and Miscellaneous Narrations From Reported Casmentioning

confidence: 99%

Primary Clear Cell Carcinoma of the Urinary Bladder

Venyo

2014

International Scholarly Research Notices

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Primary clear cell carcinoma of the urinary bladder (PCCUB) is rare. Literature review has revealed 47 cases of PCCUB which commonly affects women. The histogenesis of PCCUB is not certain and Müllerian origin and urotheilal origin have been postulated. The microscopic characteristics of PCCUB include cells with abundant clear cytoplasm, arranged in a solid, glandular, tubulocystic, or papillary pattern. The cells may be flat or cuboidal with abundant clear eosinophilic cytoplasm. Hobnailing may be evident. PCCUB, on immunohistochemistry, stain positively with pan-cytokeratin, cytokeratin 7, and CA 125. PCCUB may manifest with visible haematuria, lower urinary tract symptoms, and discharge. There is no consensus opinion regarding the best treatment option for PCCUBs and patient outcomes are not very clear. Surgery has been the adopted treatment of choice. Differential diagnoses of PCCUB include nephrogenic metaplasia, urothelial carcinoma with clear cell cytoplasm, diffuse large B-cell lymphoma, and metastatic clear cell carcinoma with the primary originating elsewhere. Conclusions. A thorough radiological imaging assessment is required in cases of PCCUB to exclude a primary tumour elsewhere. Urologists and oncologists should report cases of PCCUB they encounter and should enter them into a multicentric trial to ascertain the best management option.

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Section: Discussion and Miscellaneous Narrations From Reported Casmentioning

confidence: 99%

Primary Clear Cell Carcinoma of the Urinary Bladder

Venyo

2014

International Scholarly Research Notices

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“…While it has been previously observed that CCA may focally resemble NA, this study is the first to document a series of CCA which closely resembles NA throughout the tumor. As most regard the presence of solid sheets of cells, abundant clear cytoplasm, and significant nuclear atypia as keys to the diagnosis of CCA, the absence of these features make an accurate diagnosis of this entity more challenging, even in larger tissue samples [4,5,8,13,14].…”

Section: Discussionmentioning

confidence: 99%

“…Some studies have also questioned whether NA is a precursor lesion to CCA [6,21,22]. A history of prior NA in some patients, as well as some similarity in immunohistochemical staining, has been used to favor this hypothesis [1,3,6,8,23]. Moreover, a single case report has provided molecular evidence of a common origin of the NA and CCA, although it is only a single case and the possibility exists that the "NA" in this case could have been a NAlike CCA [24].…”

Section: Discussionmentioning

confidence: 99%

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Clear cell adenocarcinoma of the bladder and urethra: cases diffusely mimicking nephrogenic adenoma

et al. 2010

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“…The gross appearance is nonspecific, but the tumor frequently grows as a papillary mass [1, 8–10]. The most common locations are the bladder neck, trigone, and lateral bladder wall [1, 4, 6, 9, 11] and the dome [12]. The most common architectural pattern is tubulocystic, followed by papillary, glandular, and diffuse [1, 8–13].…”

Section: Introductionmentioning

confidence: 99%

Concordant clear cell “mesonephric” carcinoma of the bladder and lung adenocarcinoma with clear cell features – multiple primaries versus metastatic neoplasms: a case report

et al. 2017

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BackgroundClear cell carcinoma of the bladder is a rare variant of urinary bladder adenocarcinoma. We report a case of a patient with clear cell carcinoma of the bladder and a concordant right upper lobe pulmonary adenocarcinoma with clear cell features, and we address the role of immunohistochemistry and cytogenetic analysis in distinguishing the two primary malignancies.Case presentationOur patient was a 59-year-old African American woman who presented with hematuria. Her past medical history included invasive mammary carcinoma and end-stage renal disease treated with hemodialysis. A computed tomographic urogram revealed a 3-cm polypoid bladder mass. A follow-up chest computed tomographic scan revealed a 1-cm right upper lobe nodule. The patient underwent transurethral biopsy and subsequent radical cystectomy, as well as a transthoracic core needle biopsy of the lung nodule. Histologically, the bladder tumor consisted of flat, cuboidal to columnar cells with clear or eosinophilic cytoplasm and a hobnail appearance, organized in tubulocystic and papillary patterns. The neoplastic cells were diffusely positive for α-methylacyl-coenzyme A racemase, cancer antigen 125, and cytokeratin 7; focally positive for cytokeratin 20, P53, and carcinoembryonic antigen; and negative for thyroid transcription factor 1. The lung tumor demonstrated a glandular architecture with mucin production (positive for mucin with mucicarmine and periodic acid-Schiff with diastase stain). The neoplastic cells were diffusely positive for cytokeratin 7, napsin A, and thyroid transcription factor 1, and they were negative for cytokeratin 20 and cancer antigen 125. Genetic testing of the pulmonary neoplasm demonstrated ARID2 genomic alterations.ConclusionsThe presence of clear cell features in both neoplasms raised the possibility of lung metastasis from the primary bladder tumor. However, the glandular architecture of the lung neoplasm along with its distinctive immunohistochemical and genetic profiles confirmed the presence of two separate primaries.

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Clear Cell Adenocarcinoma of the Bladder in a Male Patient: Clinicopathologic Analysis of a Case

Cited by 9 publications

References 7 publications

Primary Clear Cell Carcinoma of the Urinary Bladder

Primary Clear Cell Carcinoma of the Urinary Bladder

Clear cell adenocarcinoma of the bladder and urethra: cases diffusely mimicking nephrogenic adenoma

Concordant clear cell “mesonephric” carcinoma of the bladder and lung adenocarcinoma with clear cell features – multiple primaries versus metastatic neoplasms: a case report

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