Clear cell adenocarcinoma presenting as acute pancreatitis: A rare form of primary pancreatic malignancy

O’Neill, Robert; Lam, Lyn L.; Solanki, Parthsinh; Levingston, Robyn; Thomas, David B.

doi:10.1002/cnr2.1273

Cited by 3 publications

(4 citation statements)

References 9 publications

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“…5C-D). Negative immunostain for PAX-8, accordingly with no clinical and radiological evidence of a renal neoplasm, de nitely excluded a clear cell renal carcinoma metastasis [3], [4].…”

Section: Case Presentationmentioning

confidence: 99%

Clear Cell Carcinoma of the Pancreas Infiltrating Duodenum: A Case Report of a Multiface Aspect of an Intriguing Entity

Alfano

Villanacci

Moneghini

et al. 2022

Preprint

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Background: Although Clear-cell carcinoma has been found in various organs as a variant of ductal carcinoma of the pancreas, it still hasn’t been well recognized. According to the WHO classification, primary Clear-cell carcinoma of the pancreas is rare, and it is classified as a “miscellaneous” carcinoma. To date it has been poorly characterized and only few cases have been reported in the literature [1]. Case presentation: We report here an unusual case of Clear-cell carcinoma in a 59-year-old man involving the head of the pancreas and the second part of the duodenum initially misconceived as pyloric gland adenoma, a rare duodenal entity. Nevertheless, duodenal sub stenosis was suspected of malignancy, so further investigations were made. Subsequent abdominal computed tomography (CT) detected not only a duodenal vegetation but also an alteration of the duodenal-pancreatic interface with thickening of the duodenal wall and a common bile duct dilatation. The malignant clinical aspect and behavior of the lesion, associated to the impossibility of further investigations due to the duodenal sub stenosis, led to an exploratory laparotomy.The laparotomy revealed a retracting area straddling the duodenum and the pancreatic head. A duodenum pancreatectomy of the head of the pancreas with extended lymphadenectomy was performed and the histological evaluation showed a ductal Clear-cell adenocarcinoma of the pancreas infiltrating the duodenum. The postoperative course was characterized by a pancreatic fistula grade B. At 6 months from the surgery, the patient hasn’t had recurrence.Conclusion: Because it is a rare tumor with very few cases reported previously, the incidence and prognosis are not well known for this neoplasm. The report of our case would aid in the identification of this rare neoplasm. Further studies and more case reports are needed to clarify the diagnosis and prognostic significance of the clear cell differentiation of these tumors.

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“…5C-D). Negative immunostain for PAX-8, accordingly with no clinical and radiological evidence of a renal neoplasm, de nitely excluded a clear cell renal carcinoma metastasis [3], [4].…”

Section: Case Presentationmentioning

confidence: 99%

Clear Cell Carcinoma of the Pancreas Infiltrating Duodenum: A Case Report of a Multiface Aspect of an Intriguing Entity

Alfano

Villanacci

Moneghini

et al. 2022

Preprint

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“…Finally, O’Neill and colleagues described a 63-year-old man who was found to have a pancreatic neck mass with liver deposits [ 27 ]. The liver biopsy showed nests of round cells, large nuclei, clear cytoplasm, and well-defined membranes.…”

Section: Reviewmentioning

confidence: 99%

“…The tumor can arise from the body [ 11 - 12 , 16 ], head [ 13 , 15 , 18 - 20 , 30 ], tail [ 17 , 23 - 25 ], or even the neck of the pancreas [ 27 ]. There are other cases that presented with metastasis at diagnosis [ 11 - 12 , 19 , 23 - 25 , 27 ]. Most of the authors have described treating CCCP in the same manner as PDAC would have been treated in each time period.…”

Section: Reviewmentioning

confidence: 99%

“…Although some patients were smokers and had a history of drinking alcohol, the information needed to derive any conclusions from these modifiable risk factors remains poor. It remains unknown how current PDAC therapies impact CCCP, but in the most recent case report described, we see that the patient has responded well to gemcitabine and nab-paclitaxel and will be followed up in the future [ 27 ].…”

Section: Reviewmentioning

confidence: 99%

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Primary Clear Cell Carcinoma of the Pancreas: A Systematic Review

Tannous¹,

Rodriguez²,

Mak³

et al. 2021

Cureus

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Over the years, the world has witnessed many advances in diagnosing and treating multiple types of cancers. These breakthroughs have revolutionized the understanding of the molecular drive behind these neoplasms, leading to tangible therapeutic evolution and promising prognostic implications. However, pancreatic cancer remains a highly lethal disease. With recent discoveries, modern medicine has been able to delineate histopathologic subtypes of pancreatic cancer in hopes of improved diagnosis and treatment to improve survival. A once vague entity, clear cell adenocarcinoma of the pancreas, in particular, has been better characterized on a histopathological and molecular level over the past two decades. With novel technological support, this disease has become less inconspicuous, and more researchers have reported its occurrence. Its diagnosis relies heavily on a mix of histological and immunohistochemical clues such as a clear cell cytoplasm and positivity for cytokeratins and other markers. However, new molecular markers, such as hepatocyte nuclear factor 1 beta, have been associated with this entity and may aid in further diagnostic and therapeutic strategies. This review article aims to portray how the identification and description of clear cell adenocarcinoma of the pancreas have evolved over the past few decades and how this may impact future treatment strategies.

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Long-Term Survival After Curative Resection of a Primary Clear Cell Carcinoma of the Pancreas: A Report of a Case

Bolanaki,

Nikolaou,

Pappas Gogos

et al. 2024

Cureus

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Clear cell pancreatic carcinoma, as a primary lesion, represents a rare malignant entity with very few references. As for the incidence, the clinical characteristics and the prognosis are still to be defined. Here, we present the case of a 73-year-old female who presented with epigastric pain radiating to the back, anorexia, and dyspepsia. Abdominal computed tomography (CT) showed a well-circumscribed, low-attenuating tumor with peripheral enhancement, arising from the upper border of the pancreatic head. There were no metastases or other primary tumors. Radical resection of the tumor was undertaken. Histopathology showed round-to-oval neoplastic cells with a well-defined cell membrane, prominent cell borders, abundant clear cytoplasm, and centrally located nuclei. The periodic acid-Schiff reaction was positive and a diagnosis of primary clear cell pancreatic carcinoma was made. No adjuvant treatment was given. She remained under regular follow-ups with abdominal and thoracic CT scans for seven years without evidence of recurrence of other primary tumors. She was deceased 87 months after tumor resection because of conditions unrelated to the disease. This is the first case to the best of our knowledge, of long-term survival after radical resection of a primary pancreatic clear cell carcinoma, suggesting surgery as a treatment option for this rare tumor and review of the relevant literature.

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Clear cell adenocarcinoma presenting as acute pancreatitis: A rare form of primary pancreatic malignancy

Cited by 3 publications

References 9 publications

Clear Cell Carcinoma of the Pancreas Infiltrating Duodenum: A Case Report of a Multiface Aspect of an Intriguing Entity

Clear Cell Carcinoma of the Pancreas Infiltrating Duodenum: A Case Report of a Multiface Aspect of an Intriguing Entity

Primary Clear Cell Carcinoma of the Pancreas: A Systematic Review

Long-Term Survival After Curative Resection of a Primary Clear Cell Carcinoma of the Pancreas: A Report of a Case

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