2014
DOI: 10.7860/jcdr/2014/8798.4466
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Clear Cell Atypical Fibroxantoma: A Rare Variant of Atypical Fibroxanthoma and Review of the Literature

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Cited by 8 publications
(24 citation statements)
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“…27 Morphological features were the ones usually observed in clear cell AFX and the immunohistochemical study showed expression of vimentin, CD68, and CD10 and negativity for S100 protein, melan A, HMB45, MSA, and CK. In a recently reported case, the lesion was located on the shoulder of a 74-year-old male patient.…”
Section: Discussionmentioning
confidence: 69%
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“…27 Morphological features were the ones usually observed in clear cell AFX and the immunohistochemical study showed expression of vimentin, CD68, and CD10 and negativity for S100 protein, melan A, HMB45, MSA, and CK. In a recently reported case, the lesion was located on the shoulder of a 74-year-old male patient.…”
Section: Discussionmentioning
confidence: 69%
“…Only 12 examples of clear cell AFX have been reported to date, 15,[20][21][22][23][24][25][26][27] all of them as case reports with the exception of a small series of 3 cases. 22 We present 6 new cases of this variant, representing 5% of the AFX from our files.…”
Section: Discussionmentioning
confidence: 99%
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“…The lesions can range from 1 to more than 6 cm in diameter, but are typically 1 to 2 cm . Risk factors for AFX include a history of high ultraviolet exposure, radiation exposure, previous trauma, receiving a transplant or chronic immunosuppression . Ultraviolet signature mutations in the p53 gene and pyrimidine dimers seen in affected cells support the role of sun‐mediated damage in the lesion's pathogenesis .…”
Section: Discussionmentioning
confidence: 97%
“…Thus, despite the few number of CCAFX cases reported, there is a suggested prevalence of 1–2% of AFX cases . In addition to the Touton‐like appearance of the atypical multinucleated cells and presence of numerous mitotic figures characteristic of AFX, the histology of CCAFX includes numerous clear cells with vacuolated and foamy cytoplasm . The vacuolization may result from lipid accumulation within the cytoplasm.…”
Section: Discussionmentioning
confidence: 99%