Clear cell carcinoma arising in an endometrial polyp

Maltez, Amélia; Maia, Hugo; Oliveira, Maita; Marques, D.

doi:10.1046/j.1365-2508.1998.00148.x

Cited by 6 publications

(6 citation statements)

References 4 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…5 The occurrence of serous papillary or clear cell carcinoma confined to an endometrial polyp has been previously reported during menopause. The absence of p53 overexpression in the stroma of these tumours suggests that p53 alterations are specific to the glandular epithelium.…”

Section: Discussionmentioning

confidence: 95%

Endometrial carcinoma in postmenopausal patients using hormone replacement therapy: a report on four cases

Maia¹,

Maltez²,

Calmon³

et al. 1999

Gynaecol Endoscopy

Self Cite

View full text Add to dashboard Cite

Objective To report the occurrence of endometrial carcinoma in polyps in postmenopausal patients using hormone replacement therapy (HRT). Setting A private hospital with facilities for carrying out hysteroscopy. Subjects Four postmenopausal patients who developed endometrial carcinoma while using HRT. Interventions Hysteroscopy with biopsy, immunohistochemical investigation for oestradiol, progesterone receptors and p53 overexpression. Results All four cases of carcinoma were associated with endometrial polyps. The cancerous cells were positive for oestrogen receptors, negative for progesterone receptors and showed p53 overexpression in all cases. Conclusions The lack of detectable progesterone receptors in endometrial carcinomas arising in polyps in HRT patients indicates an unopposed action of oestrogens, which may accelerate the carcinomatous changes in polyps through a p53 pathway.

show abstract

Section: Discussionmentioning

confidence: 95%

Endometrial carcinoma in postmenopausal patients using hormone replacement therapy: a report on four cases

Maia¹,

Maltez²,

Calmon³

et al. 1999

Gynaecol Endoscopy

Self Cite

View full text Add to dashboard Cite

show abstract

“…In general, EPs are benign growths with no malignant potential, although occasional cases of carcinoma can be confined to a polyp. 13 Furthermore, EPs have been associated with degeneration to carcinoma in several studies, but no real approximation has been made for this concern. Salm 4 found 4 carcinomas (0.36%) in a series with 1100 EPs, and Cohen et al 14 found 5 carcinomas (0.48%) in a population with 1034 EPs, although both were retrospective analyses.…”

Section: Discussionmentioning

confidence: 99%

Predicting Atypia Inside Endometrial Polyps

Pérez-Medina

Bajo

Huertas

et al. 2002

J of Ultrasound Medicine

View full text Add to dashboard Cite

Objective. To evaluate the efficacy of color Doppler exploration for assessing atypia inside endometrial polyps. Methods. A prospective study was conducted in a tertiary university hospital. Eight hundred six patients with endometrial polyps were studied with color Doppler sonography, and the resistive index inside the polyp stalk was obtained. The patients were then referred for hysteroscopic resection, and pathologic analysis was performed. Results. Thirty-five polyps with sonographic indications of atypia were pathologically confirmed. Sonographic indications of atypia inside 16 polyps were not confirmed. Three nonquestionable endometrial polyps had atypia inside them. Conclusions. Low Doppler resistance is highly predictive of atypia inside endometrial polyps.

show abstract

“…In spite of representing only 5% of all endometrial adenocarcinomas, clear‐cell carcinoma is usually described as having a polypoid form, 17 which may lead to diagnostic confusion. In addition, there are reports of the occurrence of clear‐cell carcinoma in benign endometrial polyps 17–19 . The cases studied may correspond to these two possibilities.…”

Section: Discussionmentioning

confidence: 85%

Is hysteroscopic appearance a safe means of differentiating malignant from benign endometrial polyps in postmenopausal women?

et al. 2001

View full text Add to dashboard Cite

Objective To determine whether the hysteroscopic appearance of endometrial polyps in postmenopausal women offers a safe method of differentiating premalignant and malignant polyps from those that are benign. Design We performed a retrospective analysis of 60 postmenopausal patients with endometrial polyps evaluated by diagnostic hysteroscopy. These polyps were histologically examined after removal in all patients. Results All polyps had a benign hysteroscopic appearance. Histological findings were: endometrial polyp without atypia in 57 patients (95%), endometrial polyp with mild atypia in one patient (1.7%), and clear‐cell adenocarcinoma in two patients (3.3%). Conclusion Hysteroscopic appearance did not provide a safe method of differentiating malignant and atypical from benign endometrial polyps. The presence of endometrial neoplasia in our series argues for the histological diagnosis of endometrial polyps occurring after the menopause.

show abstract

Clear cell carcinoma arising in an endometrial polyp

Cited by 6 publications

References 4 publications

Endometrial carcinoma in postmenopausal patients using hormone replacement therapy: a report on four cases

Endometrial carcinoma in postmenopausal patients using hormone replacement therapy: a report on four cases

Predicting Atypia Inside Endometrial Polyps

Is hysteroscopic appearance a safe means of differentiating malignant from benign endometrial polyps in postmenopausal women?

Contact Info

Product

Resources

About