Clear Cell Carcinoma Arising in Endometriosis of the Rectum Following Progestin Therapy

Pokieser, Wolfgang; Schmerker, R.; Kisser, M.; Peters-Engl, C; Mühlbauer, Hans; Walter, Ulrich

doi:10.1078/0344-0338-00198

Cited by 12 publications

(8 citation statements)

References 10 publications

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“…Currently, there is no evidence from clinical trials to show a reduced risk of malignant transformation associated with the addition of progestins. Indeed there are case reports where progression of disease is associated with progestin HRT when used without estrogen (12). On balance, combined preparations are preferred in cases with residual endometriosis, severe endometriosis, and obese patients (10).…”

Section: Discussionmentioning

confidence: 98%

Malignant transformation of residual endometriosis after hysterectomy: a case series

Karanjgaokar

Murphy

Samra

et al. 2009

Fertility and Sterility

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Section: Discussionmentioning

confidence: 98%

Malignant transformation of residual endometriosis after hysterectomy: a case series

Karanjgaokar

Murphy

Samra

et al. 2009

Fertility and Sterility

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“…To date, 29 cases of epithelial carcinomas arising in the gastrointestinal endometriosis have been reported in the English-language literature (Tab. I) (4–5–6–7, 10–11–12, 14, 18–19–20–21–22–23–24–25–26–27). Twenty-five of 29 cases (86.2%) were endometrioid adenocarcinoma, followed by 3 cases of clear cell adenocarcinoma (10.3%).…”

Section: Discussionmentioning

confidence: 99%

Endometrioid Adenocarcinoma Arising from Intestinal Endometriosis

Nasu

Okamoto

Kawano

et al. 2014

Journal of Endometriosis and Pelvic Pain Disorders

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Purpose Gastrointestinal involvement of endometriosis may exist in up to 37% of women suffering from endometriosis, but malignant transformation of intestinal endometriosis is extremely rare. In this case report, we present a case of endometrioid adenocarcinoma arising from 2 different large bowel endometriotic sites, with a review of the reported cases of epithelial malignancies developed in gastrointestinal endometriosis. Case A 33-year-old nulligravid Japanese woman was admitted for the evaluation of massive ascites. The patient had undergone a laparoscopic bilateral cystectomy for bilateral endometriomas 8 years before. At laparotomy, we found massive serous ascites, diffuse peritoneal endometriotic lesions, edematous gastrointestinal tract with small surface nodules, stenosis of the sigmoid colon and firm and thick peritoneum. No endometriotic or tumorous lesions were found in the genital tract. The patient underwent a resection of the sigmoid colon, partial resection of the transverse colon, partial omentectomy and multiple biopsies of the peritoneum and ovaries. On the histologic examination, benign endometriosis, atypical hyperplasia and grade 1 endometrioid adenocarcinoma were found to be present in the transverse and sigmoid colon. Subsequently, the patient was treated with chemotherapy consisting of paclitaxel and carboplatin under a diagnosis of endometrioid adenocarcinoma arising in the intestinal endometriosis. The patient is well without evidence of disease 26 months following the surgery. Conclusions The tumors arising from intestinal endometriosis can clinically and pathologically mimic primary neoplasms of the gastrointestinal tract. Recognition of these lesions is important because primary gastrointestinal neoplasms are managed differently from those arising in endometriosis, and these differences may have significant clinical implications.

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“…L'adjonction de progestatifs aux estrogènes serait ainsi, pour ces auteurs, indiquée dans ces cas. À l'inverse, Pokieser et al ont rapporté le cas unique d'une tumeur à cellules claires se développant à partir de lésions d'endométriose après un traitement par médroxyprogestérone seule pendant deux ans, et ce, sans estrogènes associés [26]. Il pose ainsi le problème de l'intérêt des progestatifs dans la prévention de la transformation maligne des endométrioses.…”

Section: Discussionunclassified

Transformation maligne postménopausique d’une endométriose extragénitale. À propos d’un cas

Fat

Terzibachian

Govyadovskiy

et al. 2008

Gynécologie Obstétrique & Fertilité

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Clear Cell Carcinoma Arising in Endometriosis of the Rectum Following Progestin Therapy

Cited by 12 publications

References 10 publications

Malignant transformation of residual endometriosis after hysterectomy: a case series

Malignant transformation of residual endometriosis after hysterectomy: a case series

Endometrioid Adenocarcinoma Arising from Intestinal Endometriosis

Transformation maligne postménopausique d’une endométriose extragénitale. À propos d’un cas

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