Clear cell carcinoma arising in extraovarian endometriosis: Report of three cases and review of the literature

If, Hitti; Glasberg, SS; Lubicz, Stephane

doi:10.1016/0020-7292(91)90754-s

Cited by 5 publications

(7 citation statements)

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“…The most common histology reported in the Shizuoka Cohort Study on Endometriosis and Ovarian Cancer trial was clear cell carcinoma (18/46, 39%) followed by endometrioid carcinoma type (16/ 46, 35%). Our data are consistent with the previous results in which these types have been most strongly linked with ovarian endometrioma (9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21) .…”

Section: Discussionsupporting

confidence: 93%

“…Ovarian endometrioma, an external endometriosis, can be observed in the ovary: intraperitoneal seeding of regurgitated endometrial cells, which collect and implant on the surface of the ovary, and trigger a proliferative process leading to ovarian enlargement (chocolate cyst) and sometimes adhesion of contiguous organs. Prior studies have found an increased overall cancer incidence in women with endometriosis (5)(6)(7)(8) , and many retrospective studies have documented an increased rate of endometriosis in women with ovarian cancer, especially endometrioid and clear cell histologies (9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22) . Thus, epidemiologic studies have shown that endometriosis has been shown to increase developing ovarian cancer.…”

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confidence: 99%

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Risk of developing ovarian cancer among women with ovarian endometrioma: a cohort study in Shizuoka, Japan

Kobayashi

Sumimoto

Moniwa

et al. 2007

International Journal of Gynecological Cancer

274

192

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Although some studies have indicated that endometriosis may increase the risk of developing ovarian cancer, there are no data from epidemiologic studies in Japan. We prospectively analyzed all cases of ovarian endometrioma enrolled in the prefecture-wide Shizuoka Cohort Study on Endometriosis and Ovarian Cancer Programme, which was initiated in 1985. To evaluate the risk of ovarian cancer by time periods subsequent to ovarian endometrioma diagnosis, a cohort of 6,398 women with a clinically documented ovarian endometrioma in Shizuoka between 1985 and 1995 was identified from the Shizuoka Cancer Registry (SCR), with follow-up through 2002. Ovarian cancer incidence among cohort members was ascertained by linkage to the SCR using a unique person-identification number. Standardized incidence ratios (SIR) and their 95% confidence intervals (CI) were computed by a use of prefecture-wide rates of ovarian cancer, adjusted for age and calendar year. During follow-up of up to 17 years of the ovarian endometrioma cohort, 46 incident ovarian cancers were identified, yielding that the ovarian cancer risk was elevated significantly among patients with ovarian endometrioma (SIR = 8.95, 95% CI = 4.12-15.3). The SIR did not increase with increasing follow-up duration. The risk increased with increasing age at ovarian endometrioma diagnosis, with a SIR equal to 13.2 (95% CI = 6.90-20.9) in women above 50 years of age. Our findings for the first time support the hypothesis that ovarian endometrioma increases the subsequent risk of developing ovarian cancer in Shizuoka, Japan.

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Section: Discussionsupporting

confidence: 93%

mentioning

confidence: 99%

Risk of developing ovarian cancer among women with ovarian endometrioma: a cohort study in Shizuoka, Japan

Kobayashi

Sumimoto

Moniwa

et al. 2007

International Journal of Gynecological Cancer

274

192

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“…First, endometriosis symptoms can appear on average 4.8 years (2) after the surgical scar (ranging from 1 to 20 years). Second, the delay between ''benign'' endometriosis and malignant transformation is extremely variable: the literature review of malignant degeneration in cesarean section scars (first localization of extragonadal endometriosis in order of frequency) revealed an interval of between 3 and 39 years, with a mean of 17 years (3) , which is comparable to the only two cases of malignant degeneration in episiotomy scar so far reported (Table 1) (4,5) . It is also interesting to note that perineal benign endometriosis is a rare event, with 81 published cases in the world and 11 with sphincter invasion.…”

Section: Discussionmentioning

confidence: 87%

“…In conclusion, we confirmed the first hypothesis, ie, a malignant degeneration of perineal endometriosis as a serous papillary cystadenocarcinoma (Figs. [1][2][3][4].…”

Section: Case Reportmentioning

confidence: 99%

Malignant degeneration of perineal endometriosis in episiotomy scar, case report and review of the literature

Chêne¹,

Darcha²,

Déchelotte³

et al. 2007

International Journal of Gynecological Cancer

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Although malignant degeneration of cutaneous endometriosis is rare at only 0.3-1% in endometriosis surgical scars, diagnosis and management need to be defined. A case of malignant degeneration of perineal endometriosis is reported, with a review of literature. Physiopathology, epidemiological data, diagnostic and therapeutic methods are discussed for malignant degeneration of cutaneous endometriosis. Any scar lesion that evolves in response to the menstrual cycle should be considered endometriosis until proven otherwise, and thus could require surgical resection, with histological analysis. A history of cutaneous endometriosis with frequent recurrences can indicate malignant degeneration. All cases require long-term clinical follow-up because, despite the rarity of this diagnosis, the delay between benign endometriosis and malignant transformation can vary from a few months to over 40 years.

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“…But some studies suggest that certain aspects of endometriosis are similar to those of malignant disease. For example, like cancer, endometriosis can be both locally and distantly metastatic; it (7) 46 CS Clear cell carcinoma TAH/BSO/excision NED at 30 months Hitti et al (7) 43 Episiotomy Clear cell carcinoma Chemo/XRT DOD at 30 months Miller et al (3) 38 Abdominal Clear cell carcinoma Excision/chemo/XRT NED at 60 months Markopoulos et al (8) 50 CS Endometrioid carcinoma Excision NED at 24 months Gucer et al (2) 45 CS Endometrioid carcinoma Excision NA Park et al (9) 54 CS Clear cell carcinoma Excision NA Matter et al (10) 60 attaches to other tissues, invades, and damages them. There are numerous reported cases of malignancy arising from endometriotic deposits and substantial histologic evidence that endometriosis is associated with endometrioid carcinoma and clear cell carcinoma of the ovary (11) .…”

Section: Discussionmentioning

confidence: 99%

Carcinosarcoma arising from atypical endometriosis in a cesarean section scar

J¹,

Lang²,

Guo³

et al. 2006

Int J Gynecol Cancer

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Malignant change of endometriosis in a cesarean scar (CS) is rare. We report a case of carcinosarcoma arising from atypical endometriosis in a CS scar, which was successfully treated with complete excision of the lesion and repair of the abdominal wall defect with autologous skin-muscle flap graft. A 41-year-old woman presented with a recurrent endometriosis in a CS scar. Within 16 years it changed from benign to atypical endometriosis and finally to carcinosarcoma after three operations. Complete excision of the tumor was performed, with a big defect of abdominal wall successfully repaired by autologous pedicle skin-muscle graft. The diagnosis of carcinosarcoma arising from atypical endometriosis was confirmed histologically. The lesion recurred 6 months after the fourth operation. She died of disease 15 months after the fourth operation. This case demonstrated that long-standing recurrent scar endometriosis could undergo malignant changes and should be made aware. The primary treatment is complete surgical excision.

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Clear cell carcinoma arising in extraovarian endometriosis: Report of three cases and review of the literature

Cited by 5 publications

References 0 publications

Risk of developing ovarian cancer among women with ovarian endometrioma: a cohort study in Shizuoka, Japan

Risk of developing ovarian cancer among women with ovarian endometrioma: a cohort study in Shizuoka, Japan

Malignant degeneration of perineal endometriosis in episiotomy scar, case report and review of the literature

Carcinosarcoma arising from atypical endometriosis in a cesarean section scar

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