Clear Cell Hidradenoma of the Axilla: a Case Report with Literature Review

Cho, Kyung Eun; Son, Eun Ju; Kim, Jeong Ah; Youk, Ji Hyun; Kim, Min Jung; Kwak, Jin Young; Jeong, Joon

doi:10.3348/kjr.2010.11.4.490

Cited by 19 publications

(25 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Because the incidence is low, these tumors are rarely reported based on radiological findings. Similar to our case, clear cell hidradenomas tend to be well-circumscribed and cystic with a variable solid portion and hypervascularity on ultrasound imaging [6]. …”

Section: Discussionsupporting

confidence: 70%

Malignant Clear Cell Hidradenoma of the Breast

Chambers

Rahal

Reddy

et al. 2017

Cureus

View full text Add to dashboard Cite

A 58-year-old female had a mass in the right breast palpable beneath the areola. A mammogram revealed a 1.5-centimeter soft tissue density that was confirmed with a subsequent ultrasound. The patient underwent a core needle biopsy which was initially reported as a moderately differentiated invasive ductal carcinoma. Immunohistochemical analysis revealed negative staining for estrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor receptor (HER2), mammaglobin, and gross cystic disease fluid protein 15 (GCDFP-15). A wide local excision of the mass was performed. The pathology report stated the tumor had an infiltrative growth pattern with a desmoplastic stromal response with enhanced epithelial atypia consistent with malignant transformation of a nodular clear cell hidradenoma. Clear cell hidradenoma is a very rare tumor originating from the sweat gland and has a propensity for the face and extremities. The malignant variant of this tumor is extremely rare and has been reported to originate from the breast in few cases. This case represents the difficulty in diagnosing this tumor along with the radiographic and histologic features that can distinguish this malignancy from other entities.

show abstract

Section: Discussionsupporting

confidence: 70%

Malignant Clear Cell Hidradenoma of the Breast

Chambers

Rahal

Reddy

et al. 2017

Cureus

View full text Add to dashboard Cite

show abstract

“…3 However, its usefulness for nodular hidradenoma has been so far unclear because skin ultrasound examination of nodular hidradenoma has been described in only a few reports. 4,5 In previous published works, mass with irregular internal echo in the hypoechoic area has been reported as a common ultrasonographic feature. 4,5 On the other hand, the power Doppler effect of the tumor varies from one case to another and remains poorly understood.…”

Section: Ultrasonographic Diagnosis Of Nodular Hidradenomamentioning

confidence: 98%

“…4,5 In previous published works, mass with irregular internal echo in the hypoechoic area has been reported as a common ultrasonographic feature. 4,5 On the other hand, the power Doppler effect of the tumor varies from one case to another and remains poorly understood. 4,5 At all events, this characteristic finding as an intracystic papillary lesion detected by ultrasonography can be a reliable one for diagnosing nodular hydradenoma.…”

Section: Ultrasonographic Diagnosis Of Nodular Hidradenomamentioning

confidence: 98%

“…4,5 On the other hand, the power Doppler effect of the tumor varies from one case to another and remains poorly understood. 4,5 At all events, this characteristic finding as an intracystic papillary lesion detected by ultrasonography can be a reliable one for diagnosing nodular hydradenoma. 4,5 In conclusion, our case emphasizes that skin ultrasonography is a useful tool for predicting nodular hidradenoma before excision.…”

Section: Ultrasonographic Diagnosis Of Nodular Hidradenomamentioning

confidence: 99%

See 1 more Smart Citation

Ultrasonographic diagnosis of nodular hidradenoma

Horie

Ito

2015

The Journal of Dermatology

View full text Add to dashboard Cite

“…Hidradenomas, also known as nodular hidradenomas, are skin adnexal neoplasms occasionally reported to occur in the breast [9,10,11,12,13,14,15,16,17,18]. These tumors are thought to derive from apocrine or distal eccrine sweat duct origin, and a subset have been reported with a recurrent t(11;19), resulting in a MECT1-MAML2 fusion protein [19].…”

Section: Introductionmentioning

confidence: 99%

Atypical Hidradenoma Mimicking Primary Mammary Carcinoma on Breast Fine-Needle Aspiration: A Case Report with Long-Term Follow-Up

Rooper

Iding

Cuda³

et al. 2016

Acta Cytologica

View full text Add to dashboard Cite

Background: Fine-needle aspiration (FNA) is well-established as an accurate technique for the diagnosis of palpable breast masses. While the differential diagnosis of such lesions usually focuses on benign or malignant mammary proliferations, a subset of breast neoplasms arises from skin and soft tissue. Skin adnexal neoplasms such as hidradenoma can pose a particular pitfall on breast FNA cytology (FNAC) as epithelial proliferations that are not of ductal or lobular origin. Case: A 59-year-old female presented with a superficial breast mass. FNAC revealed a hypercellular lesion with marked nuclear atypia that was highly suspicious for carcinoma. However, at partial mastectomy, the histological features of the tumor were consistent with atypical hidradenoma. Negativity for estrogen receptor (ER) and progesterone receptor (PR) confirmed the diagnosis. Eighteen years later, the patient remains free of recurrence or metastasis. Conclusions: This report offers the first description of findings of atypical hidradenoma on FNAC. In the breast, its high cellularity and nuclear atypia can mimic a primary mammary carcinoma on FNAC. Although breast and skin adnexal tumors show a immunohistochemical overlap, negative ER and PR stains in a low-grade tumor can suggest a nonmammary lesion. Skin adnexal neoplasms should be considered in the differential diagnosis of superficial breast tumors.

show abstract

Clear Cell Hidradenoma of the Axilla: a Case Report with Literature Review

Cited by 19 publications

References 9 publications

Malignant Clear Cell Hidradenoma of the Breast

Malignant Clear Cell Hidradenoma of the Breast

Ultrasonographic diagnosis of nodular hidradenoma

Atypical Hidradenoma Mimicking Primary Mammary Carcinoma on Breast Fine-Needle Aspiration: A Case Report with Long-Term Follow-Up

Contact Info

Product

Resources

About