Clear cell odontogenic carcinoma: A case report and literature review

Moro, Alessandro; Gasparini, Giulio; Saponaro, Gianmarco; Barbera, Giorgio; Doneddu, Piero; Petrone, Gianluigi; Alberti, Caterina; Azzuni, Camillo; Foresta, Enrico; Todaro, Mattia

doi:10.1016/j.omsc.2021.100211

Cited by 6 publications

(2 citation statements)

References 20 publications

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“…While EWSR1 rearrangements is identified in clear cell odontogenic carcinoma, BRAF V600E point mutation is instead identified in ameloblastic carcinoma. [ 16 ] Furthermore, the spindle cell variant of AC should be differentiated from odontogenic sarcoma: spindle cell areas are negative for vimentin and positive for cytokeratin. [ 8 ] The squamous odontogenic tumour may also be mistaken for AC.…”

Section: Discussionmentioning

confidence: 99%

Ameloblastic carcinoma of the mandible

Selenne

Nancy

Valente

2023

Journal of Oral and Maxillofacial Pathology

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Ameloblastic carcinoma (AC) is a rare, primary epithelial odontogenic malignant neoplasm. It is the malignant counterpart of ameloblastoma. It comprises 1% of all cysts and tumours occurring in the jaws, arising from tissues associated with odontogenic epithelium. The objective of the present study was to describe a clinical case of a 63-year-old male with an enlargement in the mandible on the left side. Panoramic radiography revealed a radiolucent area with poorly defined borders, and an incisional biopsy was performed for the histopathological study using immunomarkers such as SOX2 and Ki-67. Ki-67 is considered a marker of cell proliferation, and SOX2 reportedly participates in the development of the ameloblastic epithelium lineage and is associated with a more aggressive clinical course. A final histopathological diagnosis of AC was given. Unfortunately, the patient died one week before surgical resection (the surgical treatment of choice for AC).

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Section: Discussionmentioning

confidence: 99%

Ameloblastic carcinoma of the mandible

Selenne

Nancy

Valente

2023

Journal of Oral and Maxillofacial Pathology

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“…[6,7]. With a higher prevalence in women over 50 years of age and associated with risk factors such as obesity, smoking, hypertension, and occupational exposure, clear cell odontogenic carcinoma does not present a similar behavior and or pattern, the nonspecificity of signs and symptoms as well as its radiographic appearance without a pattern makes the diagnosis difficult, however its most common signs and symptoms are pain or discomfort, nonspecific radiating pain in the mandible, mobility or displacement of the dental element, bleeding, pain, local ulcerations that do not regress, paresthesias and destruction of the cortical bone [5,8]. clear cells with well-defined borders and a centrally located nucleus and hyperchromatic polygonal cells with eosinophilic cytoplasm and centrically located nuclei, both embedded in a fibrous stroma.…”

Section: Discussionmentioning

confidence: 99%

Clear Cell Odontogenic Carcinoma of the Mandible, Case Report

Almeida¹

2022

J Dent Oral Sci

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Caucasian patient, ECOG-PS 0, 38 years old, presented at the hospital with symptoms of pain in the lower left region of the mandible, objectively without swelling, on radiographic examination, she presented an extensive lesion with radiolucency in the region of element 37, with image filling, displacement of element 38 and apical involvement of element 36. In the tomographic exam, he presented a lesion with great destruction of the lingual wall and accentuated bone sequestration. It was opted for the differential diagnosis of the same by biopsy of the region with partial removal of healthy and diseased tissue associated with aspiration puncture, the histopathological examination was diagnosed as odontogenic clear cell carcinoma, a rare malignant tumor of epithelial origin, common in aged over 50 years and without behavioral pattern at its emergence.

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