Clear-cell renal carcinoma metastasis to the base of the tongue and sphenoid sinus: Two very rare atypical ENT locations

Morvan, J.; Veyrières, J.-B.; Mimouni, O.; Cathelinaud, O.; Allali, L.; Verdalle, P.

doi:10.1016/j.anorl.2010.11.003

Cited by 31 publications

(17 citation statements)

References 8 publications

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“…17 In the second part of our analysis, we focused our attention on the organ-specific effect of metastases. Although RCC can metastasise to virtually any organ, 18 we confirmed that lung and bone represent the two at a higher prevalence of metastases from RCC, at least in patients who are candidates for surgical debulking. Interestingly, conversely to bone or liver, multiple metastases frequently affect lungs without any other site affected.…”

Section: Discussionsupporting

confidence: 69%

Effect of number and location of distant metastases on renal cell carcinoma mortality in candidates for cytoreductive nephrectomy: Implications for multimodal therapy

et al. 2012

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Abbreviations & AcronymsObjective: To test whether the combination of number and location of distant metastases affects cancer-specific survival in patients with metastatic renal cell carcinoma. Methods: Overall, 242 metastatic renal cell carcinoma patients with synchronous metastases at diagnosis underwent cytoreductive nephrectomy at a single institution. Combinations of number and location of distant metastases were coded as: single metastasis and single organ affected, multiple metastases and single organ affected, single metastasis for each of the multiple organs affected, and multiple metastases for each of the multiple organs affected. Covariates included age, symptoms, performance status, American Society of Anesthesiologists score, hemoglobin, lactate dehydrogenase, tumor size, Fuhrman grade, T stage, lymph node status, necrosis, sarcomatoid features and metastasectomy at the time of nephrectomy. Results: The median survival was 34.7 versus 32.3 versus 29.6 versus 8.5 months for single metastasis and single organ affected, multiple metastases and single organ affected single metastasis for each of the multiple organs affected, and multiple metastases for each of the multiple organs affected patients, respectively. At multivariable analyses, the combination of number and location of distant metastases resulted in one of the most informative and independent predictors of cancer-specific survival in metastatic renal cell carcinoma patients. The lung was the location with the highest rate of single organ affected (50.3% vs 35.1% in other sites; P < 0.001). Considering only patients with a single metastasis, no statistically significantly different cancer-specific survival rates were recorded (P > 0.3) among different metastatic organs. Conclusions: Among metastatic renal cell carcinoma patients undergoing cytoreductive nephrectomy, the combination of the number and location of distant metastases is a major independent predictor of cancer-specific survival. Patients with multiple organs affected by multifocal disease are more likely to have poorer survival.

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Section: Discussionsupporting

confidence: 69%

Effect of number and location of distant metastases on renal cell carcinoma mortality in candidates for cytoreductive nephrectomy: Implications for multimodal therapy

et al. 2012

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“…Due to low radiosensitivity, surgery is the preferred option if the tumor can be resected without unacceptable functional sequelae [15] .…”

Section: Discussionmentioning

confidence: 99%

Gallbladder’s clear cell renal carcinoma metastasis: A case report

Ruiz

Pedrazzoli

Bonacini

2016

International Journal of Surgery Case Reports

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“…First-line treatment is surgical, due to low radiosensitivity, with radiation therapy as a possible second line [10][11].…”

Section: Discussionmentioning

confidence: 99%

Metastasis to Paranasal Sinuses as the First Presenting Sign of Renal Cell Carcinoma

Bechara¹,

Júnior²,

Gouveia³

et al. 2012

OJU

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The clear cell carcinoma is a relatively rare tumor, represented approximately 85% by renal cell carcinoma (RCC), but has a characteristic of early metastatic, which sometimes spread to unusual places. Metastatic tumors in the paranasal sinuses are very rare. This case report a 65 years-old patient who presented sinusitis and epitaxis as a first sign of renal cell carcinoma with metastasis to the right maxillary sinus, which was opereted at Lagoa Hospital-RJ and strengthen the inclusion of this disease in the differential diagnosis of sinus disease. The renal cell carcinoma is a relatively rare tumor, representing approximately 3% of malignant tumors. About a third of patients with renal cell carcinoma have metastasis at diagnosis. The sinuses are a rare location of metastasis. The maxillary sinuses and the paranasal sinuses are most commonly affected by metastatic tumors to the sinuses region. The most frequent primary tumor to metastasis to paranasal sinuses is the renal cell carcinoma. This report highlights the rarity of the case and the importance in the differential diagnosis of sinus disease.

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Clear-cell renal carcinoma metastasis to the base of the tongue and sphenoid sinus: Two very rare atypical ENT locations

Abstract: Such metastases may sometimes occur years after the discovery of the primitive renal tumor; any history of kidney cancer should, therefore, be noted in patients with suspect ENT lesions.

Cited by 31 publications

References 8 publications

Effect of number and location of distant metastases on renal cell carcinoma mortality in candidates for cytoreductive nephrectomy: Implications for multimodal therapy

Effect of number and location of distant metastases on renal cell carcinoma mortality in candidates for cytoreductive nephrectomy: Implications for multimodal therapy

Gallbladder’s clear cell renal carcinoma metastasis: A case report

Metastasis to Paranasal Sinuses as the First Presenting Sign of Renal Cell Carcinoma

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