Clear cell renal cell carcinoma bone metastasis: What should be considered in prognostic evaluation

Huang, Zixiong; Du, Yiqing; Zhang, Xiaopeng; Liu, Huixin; Liu, Shijun; Xu, Tao

doi:10.1016/j.ejso.2019.01.221

Cited by 19 publications

(16 citation statements)

References 24 publications

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“…However, the survival time after metastasis is about 12 months for mRCC patients (6). There were studies found that the prognosis of RCC patients with bone metastasis is closely related to age, TNM stage, other organ metastasis, whether receive targeted treatment (7,8). However, these predictions have not been validated effectively due to the rarity of the disease and there is still a lack of a predictive model that calculates different variables simultaneously.…”

Section: Introductionmentioning

confidence: 99%

Survival nomogram for patients with bone metastatic renal cell carcinoma: A population-based study

Wang

et al. 2021

Int. braz j urol.

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Purpose: Increased attention has been focused on the survival of renal cell carcinoma (RCC) patients with bone metastasis. This study proposed to establish and evaluate a nomogram for predicting the overall survival (OS) and cancer-specific survival (CSS) of RCC patients with bone metastasis. Materials and Methods: RCC patients with bone metastasis between 2010 and 2015 were captured from the surveillance, epidemiology and end results (SEER) database. Univariate and multivariate cox regressions were performed to assess the effects of clinical variables on OS and CSS. The nomogram based on the Cox hazards regression model was developed. Concordance index (C-index) and calibration curve were performed to evaluate the accuracy of nomogram models, receiver operating characteristic (ROC) curves and decision curve analysis (DCA) were conducted to assess the predict performance. Results: A total of 2.471 eligible patients were enrolled in this study. The patients were assigned to primary (n=1.672) and validation (n=799) cohorts randomly. The 1-, 2-, and 3-year OS and CSS nomogram models were constructed based on age at diagnosis, sex, marital status, pathological grade, T-stage, N-stage, brain/liver/lung metastasis, surgery, radiotherapy and chemotherapy. The c for OS and CSS prediction was 0.730 (95% confidence interval [CI]: 0.719-0.741) and 0.714 (95%CI:0.702-0.726). The calibration curves showed significant agreement between nomogram models and actual observations. ROC and DCA indicated nomograms had better predict performance. Conclusions: The nomograms for predicting prognosis provided an accurate prediction of OS and CSS in RCC patients with bone metastasis, and contributed clinicians to optimize individualized treatment plans.

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Section: Introductionmentioning

confidence: 99%

Survival nomogram for patients with bone metastatic renal cell carcinoma: A population-based study

Wang

et al. 2021

Int. braz j urol.

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“…All patients in Table 4 were male. Studies have reported a 4:1 male predominance in clear cell renal cell carcinoma with bone metastasis [57]. Almost all the patients received surgical treatment.…”

Section: Discussionmentioning

confidence: 99%

“…As no therapeutic standard or guideline currently exists for RCC with bone metastasis. The median survival time of RCC with bone metastasis is usually below 24 months [57]. Acrometastases are often associated with extensive metastasis in other sites, so the prognosis is poor.…”

Section: Discussionmentioning

confidence: 99%

Metatarsal metastasis from clear cell renal cell carcinoma: a case report and literature review

Han

Zhang

et al. 2020

BMC Urol

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Background: Bone metastasis is known to occur in some patients with cancer, usually in the spine, pelvis or ribs, and less than 0.01% of patients have metastases in the foot bone, so metatarsal metastasis is quite rare. The initial symptoms of osseous metastases are swelling, pain, or both. Case presentation: We report a 68-year-old man with solitary metatarsal metastasis 26 months after a diagnosis of renal clear cell carcinoma. The patient suffered intermittent swelling of his right foot and pain for one year due to trauma and was not treated. The doctor attributed the symptoms to trauma, administering massage therapy and a plaster cast to the patient at the local clinic. After reviewing the medical records, we found that this patient had a history of clear cell renal cell carcinoma. The patient underwent radiological examination and open biopsy of the first metatarsal bone of the right foot. These findings confirmed that the patient had a metatarsal metastasis from clear cell renal cell carcinoma. The patient subsequently underwent right foot amputation. No local recurrence or distant metastasis was found after a 6-month follow-up. Conclusion: Clinicians should be aware of a history of renal cell carcinoma (RCC) and fully understand the patient's past medical history. When treating patients with clear cell renal cell carcinoma who have unresolving bony pain or swelling, clinicians should always keep in mind the possibility of bone metastasis of RCC.

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“…12 The presence of bone metastasis in renal cell carcinoma is also associated with poor prognosis. 13 Shoulder impairment and dysfunction in cancer patients have been merely studied. Studies have been conducted only on breast cancer patients because treatment for breast cancer directly involves neuromusculoskeletal tissues of one or more shoulder girdle regions.…”

Section: Lessons From the Casementioning

confidence: 99%

“…12 The presence of bone metastasis in renal cell carcinoma is also associated with poor prognosis. 13…”

Section: Lessons From the Casementioning

confidence: 99%

Shoulder pain in a patient with renal cell carcinoma? Suprascapular neuropathy caused by bone metastasis of renal cell carcinoma: A case report

et al. 2021

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Background: Pain management is crucial in palliative care for patients with advanced cancer. Here, we report a case of shoulder pain in a patient with renal cell carcinoma. Case presentation: A 36-year-old male diagnosed metastatic renal cell carcinoma presented with pain and weakness on left shoulder for more than 6 months. Physical examination showed limited range of motion and atrophic changes on supraspinatus and infraspinatus muscles. Weakness in shoulder abduction and external rotation was also noted. Possible courses of action: In this case, suprascapular neuropathy, adhesive capsulitis of shoulder and metastatic lesions involving shoulder joint were suspected. Formulation of a plan: We planned imaging studies including X-ray, bone scan, magnetic resonance imaging, and electrodiagnostic studies. Outcome: Imaging and electrodiagnostic studies showed suprascapular neuropathy by bone metastasis. Conservative treatment including injection and rehabilitation therapy reduced the patient’s pain and improved the range of motion limitation. Lessons from the case: Clinicians should be aware that bone metastasis in patients with advanced cancer can cause suprascapular neuropathy, shoulder pain and shoulder dysfunction. View on research problems, objectives, or questions generated by the case: More research is expected on development of an early surveillance model, barriers to cancer pain management, communication from patients’ perspectives.

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Clear cell renal cell carcinoma bone metastasis: What should be considered in prognostic evaluation

Cited by 19 publications

References 24 publications

Survival nomogram for patients with bone metastatic renal cell carcinoma: A population-based study

Survival nomogram for patients with bone metastatic renal cell carcinoma: A population-based study

Metatarsal metastasis from clear cell renal cell carcinoma: a case report and literature review

Shoulder pain in a patient with renal cell carcinoma? Suprascapular neuropathy caused by bone metastasis of renal cell carcinoma: A case report

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