Clear cell sarcoma of the penis

Clear cell sarcoma of tendons and aponeuroses, and osteoclast-rich tumour of the gastrointestinal tract with features resembling clear cell sarcoma of soft parts: a review and update

“…The tumour most often involves the foot and ankle, with less common sites of involvement including the knee, thigh, hand, elbow and forearm. Isolated cases of CCS occurring in the head/neck,25 trunk,26 penis,27 retroperitoneum,28 bone,29 kidney17 and gastrointestinal tract30 have been reported. CCS is typically a deeply situated lesion that often appears to arise from or in association with the tendons and aponeuroses, involving the skin only in long-standing or larger lesions.…”

EWS-ATF1 fusion transcripts in gastrointestinal tumors previously diagnosed as malignant melanoma

“…Recent case reports have demonstrated that CCS can involve a wide range of anatomic sites beyond the soft tissues including the dermis [14], ear [15], penis [16], kidney [17], and gastrointestinal (GI) tract including the stomach [18], duodenum [19], ileum [20], and transverse colon [21]. The description of primary CCS of the GI tract raises an important issue in differential diagnosis because cutaneous melanoma is well known to metastasize to the GI tract [22,23], but CCS and metastatic melanoma (MM) are essentially indistinguishable by morphologic, immunohistochemical, and electron microscopic features [6].…”

Clear Cell Sarcoma of the Jaw

“…In the majority of cases, the primary tumor was located in the foot (including toes), ankle/heel, knees/popliteal fossa, thigh, buttock, back, arm (including elbow), wrist, fingers, shoulder, chest wall, and abdominal wall (Fig. 9 Other unusual locations included cheek 10 ; paraspinal, paravertebral, and dorsal root 9,4,11,12 ; GI tract (upper GI and stomach); penis 13 ; kidney (primary, not CSS of the kidney) 1 ; and lung (primary site). Rare locations included bone as the primary site: rib, 5 humerus 6 (this tumor was negative for HMB-45 and S-100, which is atypical for CCS, see discussion below), scapula, 7 tibia, 8 and ulna 8 ; muscle as the primary site: sternocleidomastoid muscle, 9 masseter muscle, 9 and trapezius muscle.…”