Clear cell sarcoma of the mediastinum

Tirabosco, Roberto; Lang-Lazdunski, Loı̈c; Diss, TC; Amary, Maria Fernanda; Rodriguez‐Justo, Manuel; Landau, David; Lorenzi, Will; Flanagan, Adrienne M.

doi:10.1016/j.anndiagpath.2008.02.014

Cited by 12 publications

(10 citation statements)

References 21 publications

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“…Clear cell sarcomas, mostly present on the distal extremities in young adults, have also been reported at unusual sites, such as the pelvis, kidney, gastrointestinal tract, skin, breast, and mediastinum [6,[9][10][11][12][13][14][15][16]. Although classic histologic features as first described by Enzinger [9] are present in the majority of cases, morphological variations are also recorded.…”

Section: Discussionmentioning

confidence: 95%

EWSR1-ATF1 chimeric transcript in a myoepithelial tumor of soft tissue: a case report

Flucke¹,

Mentzel²,

Verdijk³

et al. 2012

Human Pathology

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Section: Discussionmentioning

confidence: 95%

EWSR1-ATF1 chimeric transcript in a myoepithelial tumor of soft tissue: a case report

Flucke¹,

Mentzel²,

Verdijk³

et al. 2012

Human Pathology

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“…Of all published studies on CCSs, there are only 2 reported cases in the literature involving mediastinum [11, 12]. Morphologic appearances in both cases were similar to cutaneous melanoma.…”

Section: Discussionmentioning

confidence: 92%

Primary mediastinal clear cell sarcoma: a case report and review of the literature

et al. 2017

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BackgroundClear cell sarcoma (CCS) is a rare malignant soft-tissue neoplasm that displays melanocytic markers and exhibits striking histopathological features. The tumour has a predilection for the lower extremities and rarely presents in the mediastinum.Case presentationWe present a case of primary mediastinal CCS in a 57-year-old man. Computer tomography (CT) revealed a 12 × 12 × 7.5 cm mass in the anterior mediastinum. Microscopically, the tumour mainly consisted of epithelioid cells with oval vesicular nuclei and eosinophilic cytoplasm. Immunohistochemically, the tumour was positive for human melanoma black 45 (HMB-45) and vimentin but negative for S-100 and Melan-A. Fluorescence in situ hybridisation (FISH) showed a translocation involving the EWSR1 gene region.ConclusionThis report will illustrate that the mediastinum is a potential site for primary CCS and FISH plays an important role in making a conclusive diagnosis.

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“…Our case was diagnosed with a primary CCS in the mediastinum. A search of the English literature revealed only one previously reported case of primary CCS in the mediastinum [4]. …”

Section: Discussionmentioning

confidence: 99%

Primary Clear-Cell Sarcoma in the Mediastinum

et al. 2014

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We report a case of primary clear-cell sarcoma (CCS) in the mediastinum. In October 2011, a 63-year-old man was admitted to our hospital for surgical resection. The tumor was completely excised by video-assisted thoracoscopic surgery. The tumor was well encapsulated and did not invade the pleura. Histological examination led to a final diagnosis of primary CCS in the mediastinum. The patient remains alive without evidence of recurrence at 15 months after surgery.

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Clear cell sarcoma of the mediastinum

Cited by 12 publications

References 21 publications

EWSR1-ATF1 chimeric transcript in a myoepithelial tumor of soft tissue: a case report

EWSR1-ATF1 chimeric transcript in a myoepithelial tumor of soft tissue: a case report

Primary mediastinal clear cell sarcoma: a case report and review of the literature

Primary Clear-Cell Sarcoma in the Mediastinum

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