Clear cell tumor of the lung

Abstract

Clear cell tumor of the lung is a rare benign tumor. We report herein a case of clear cell tumor of the lung. A 45 year-old woman with a round mass lesion of approximately 2 cm diameter on chest X-ray underwent a thoracotomy. Pathologic examination revealed sheets of large round or polygonal cells with clear cytoplasm and immunoreactive positivity for HMB-45 and vimentin. Investigation with abdominal CT scans showed no evidence of renal disease, and the tumor was diagnosed as clear cell tumor of the lung.

Clear cell tumor of the lung: a case report and literature review

“…The clear cell tumor has to be differentiated from other malignant clear-cell tumors, particularly unusual primary clear cell adenocarcinoma of the lung and metastatic renal cell carcinoma, both of which can have a bland morphologic appearance and, therefore, can mimic CCTL. The tumor cells in both primary and secondary clear cell adenocarcinomas of the lung are positive for cytokeratin, whereas CCTL cells are always non-reactive for cytokeratin [22]. In our case, the diagnosis was based on the typical histology picture of the tumor, the positivity for PAS and HMB-45, and the absence of clinical signs of a renal tumor.…”

“…This CT finding appears to be a result of the vascular stroma [8,13,17,24], although occasionally, for an unknown reason, there is no enhancement [22]. The characteristics of CCTL, which have been described as having an intense heterogeneous enhancement in the arterial phase and homogeneous in the delay phase, have not been previously reported.…”

“…Partial resection and enucleation have been reported as treatments in previous studies [22]. Only one case of CCTL was diagnosed pre-operatively by a transbronchial lung biopsy [19], and three cases (including the case reported here) by fine-needle aspiration biopsy [9,23].…”

Clear cell “sugar“ tumor of the lung — case report

“…The treatment for sugar tumor of the lung is limited to a surgical procedure: lobectomy, segmentectomy, partial resection and enucleation [21].…”

Early clear cell “sugar” lung cancer management: A case report and a brief literature review

“…These immunohistochemical features discriminate CCTL from pulmonary metastasis related to primary renal cell carcinoma, clear cell variants of squamous cell carcinoma, and clear cell adenocarcinoma . Radiological features on contrast‐enhanced computed tomography (CT) show intense heterogeneous enhancement in the arterial phase (wash‐in) and washout in the delayed phase, as a probable result of the tumor vascular stroma . Because of its low metastatic potential, CCTL generally has a benign prognosis, although a few malignant clinical cases have been reported .…”