Clear cell variant of calcifying epithelial odontogenic tumor: Case report with immunohistochemical findings

Turatti, Eveline; Brasil, Juviano; Andrade, Bruno Augusto Benevenuto de; Romañach, Mário José; Almeida, Oslei Paes de

doi:10.4317/jced.51995

Cited by 14 publications

(12 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Section: Peripheral Ceot Casesmentioning

confidence: 99%

“…Long-term follow-up of the central variant of CEOT has shown the best results, with no recurrence following block resection with safe margins; however, well-documented cases are scarce [ 1 , 24 ]. Additionally, there is discussion regarding aggressive behavior involving clear cells in the CEOT [ 1 , 21 , 24 ]. Other odontogenic lesions with clear cells including ameloblastoma and clear cell odontogenic tumors have been reclassified as malignant, in which a more aggressive course can be expected [ 24 , 25 ].…”

Section: Peripheral Ceot Casesmentioning

confidence: 99%

“…Other odontogenic lesions with clear cells including ameloblastoma and clear cell odontogenic tumors have been reclassified as malignant, in which a more aggressive course can be expected [ 24 , 25 ]. Nonetheless, this premise has not been confirmed for CEOT because the latest review of all central variants showed no conclusive data regarding the worse course for this type of lesion [ 1 , 24 , 25 ].…”

Section: Peripheral Ceot Casesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“…Calcifying Epithelial Odontogenic Tumor (CEOT) is an uncommon jaw lesion with a benign and slow-growing pattern but locally aggressive course [ 1 ]. The lesions are most prevalent among patients aged 30 to 50 years, and no sex predilection has been observed [ 1 , 2 ]. Clinically, the CEOT appears as a slowly asymptomatic expansion with radiolucent honeycomb appearance in the posterior areas of the mandible [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Is Conservative Surgery the Best Approach for Peripheral Calcifying Epithelial Odontogenic Tumors?

Flores

Schneider

Vasconcelos

et al. 2018

TODENTJ

View full text Add to dashboard Cite

Background:Peripheral Calcifying Epithelial Odontogenic Tumors (CEOT) rich in clear cells are a rare entity in the oral cavity, with only 14 previous case reports in the English literature. None have discussed recommended treatment approaches for extraosseous CEOT.Objective:This brief descriptive review describes a treatment approach for peripheral CEOT including the clear cell variant.Study design:A complete review of all well-documented extraosseous case reports with an emphasis on the treatment was performed. Additionally, the present article reports a case of a 21-year-old woman with an asymptomatic swelling in the gingiva finally diagnosed as peripheral CEOT abundant in clear cells.Results:Twenty-four cases of peripheral CEOT were described; conservative surgery was the first treatment approach in approximately 80% of cases, with only one recurrence.Discussion:Clear cell finding was not associated with more aggressive behavior.Conclusion:Conservative surgery may be an advantageous approach for this group of peripheral lesions with or without clear cells, with a recurrence rate of approximately 4%.

show abstract

Section: Peripheral Ceot Casesmentioning

confidence: 99%

Section: Peripheral Ceot Casesmentioning

confidence: 99%

Section: Peripheral Ceot Casesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Is Conservative Surgery the Best Approach for Peripheral Calcifying Epithelial Odontogenic Tumors?

Flores

Schneider

Vasconcelos

et al. 2018

TODENTJ

View full text Add to dashboard Cite

show abstract

Microcystic Calcifying Epithelial Odontogenic Tumor

Sánchez‐Romero

Carlos²,

Almeida

et al. 2017

Head and Neck Pathol

View full text Add to dashboard Cite

Microcystic variant of calcifying epithelial odontogenic tumor is rare. We herein describe an additional well-documented case of microcystic CEOT. The affected patient is a Guatemalan 42-year-old female with an expansile well-defined mixed radiolucent-radiopaque lesion located in the right posterior mandible. The lesion was associated to an unerupted third molar. Histopathologic examination revealed nests and cords of moderately pleomorphic, eosinophilic polyhedral epithelial cells surrounded by a fibromyxoid stroma. The neoplastic cells showed microcystic pattern made of pseudo-glandular spaces with variable diameter. Occasional amyloid deposits and calcified acellular material were observed. Tumor cells were positive for AE1/AE3, CK14, CK19, p63, CD138, and beta-catenin. Conservative surgical resection was performed with an uneventful immediate post-surgical follow-up. After 1 year follow-up there is no evidence of recurrence. Pathologists should be aware of this unusual microcystic presentation of CEOT, which may pose a diagnostic challenge and potential diagnostic dilemma.

show abstract

CEOT Variants or Entities: Time for a Rethink? A Case Series with Review of the Literature

Siriwardena

Speight

Franklin

et al. 2020

Head and Neck Pathol

View full text Add to dashboard Cite

The first detailed description of calcifying epithelial odontogenic tumor (CEOT) are ascribed to Jens Pindborg, but this tumor was described some years previously. Subsequently, CEOT was included in the 1971 WHO classification of odontogenic tumors and a since then number of variants have been described, which have added confusion to the diagnostic criteria. We aimed to survey the literature on the variants of CEOT, in parallel with a review of our single institution experience of CEOTs. Cases identified were collated, including available clinical, radiological and histological information and then reviewed, taking into account changes in the understanding and classifications of odontogenic tumors since initial diagnosis. We identified 26 cases from 1975 to 2017 for which histological material was available. Of these, only 13 (50%) showed the "classic" histological appearance, whilst two cases were identified as recognized variants. In 11 cases, other diagnoses or a differential diagnosis were preferred, with no agreed diagnosis in four of these. The proliferation fraction (Ki67) in the 10 cases tested was 2.1% ± 0.18. These findings illustrate the diagnostic challenges in this group of tumors and highlight the gaps in knowledge. Techniques, such as EWSR1 gene cytogenetic analysis, may be helpful in cases with clear cells. However, in other areas of controversy, including the non-calcifying and Langerhans cell rich variants, further investigation, perhaps utilizing sequencing technologies may be needed to refine the classification. Owing to the relative rarity of these lesions it would be beneficial if future work could be pursued as an international collaboration.

show abstract

Clear cell variant of calcifying epithelial odontogenic tumor: Case report with immunohistochemical findings

Cited by 14 publications

References 15 publications

Is Conservative Surgery the Best Approach for Peripheral Calcifying Epithelial Odontogenic Tumors?

Is Conservative Surgery the Best Approach for Peripheral Calcifying Epithelial Odontogenic Tumors?

Microcystic Calcifying Epithelial Odontogenic Tumor

CEOT Variants or Entities: Time for a Rethink? A Case Series with Review of the Literature

Contact Info

Product

Resources

About