Clear cells in epithelial rests of Malassez

An unsuspected ameloblastoma in the subpontic region of the mandible with consideration of pathogenesis from the radiographic course

“…We theorized that the cyst lining epithelium progressed and underwent ameloblastomatous change. Histopathologically this is a feasible concept because the epithelial cell rests of Malassez, which gives rise to radicular cyst, have been implicated in the origin of multiple odontogenic cysts and neoplasms [12]. In addition, the histopathological examination results are consistent with the above consideration.…”

Botryoid Odontogenic Cyst with Extensive Clear Cells

“…Because lateral periodontal cysts usually show clear cells, most investigators have concluded that they arise from dental lamina remnants, which sometimes present clear cells, unlike reduced enamel epithelia, rests of Malassez [6]. Bascones [7] in the histopathological study of a periapical lesion attached to a superior canine in a 54-yearold male, has yielded a singular finding that may shed light on the genesis of some odontogenic lesions.…”

Hamartomatous proliferations of odontogenic epithelium within the jaws: a potential histogenetic source of intraosseous epithelial odontogenic tumors

“…Not uncommonly, the clear appearance has been recorded in small inactive epithelial islands of dentigerous cyst (39), lateral periodontal cyst (40), opercula (20) and periodontal ligament (23, 41). Of note is that the larger proliferated rests of Malassez averaging eight to 10 times the size of the normal resting type as observed in our case were found in patients over 50 years (5, 23).…”

“…Unlike conventional small rests, the present hyperplastic clear nests exhibit many overlapping features of neoplastic or pre‐neoplastic rests of Malassez in carcinogen‐administered rats (42). We are not certain whether clear cell odontogenic carcinoma is thought to be histogenetically related to the periodontal ligament rests of clear cell type (41).…”