Clearance of Fetal Products and Subsequent Immunoreactivity of Blood Salvaged at Cesarean Delivery

Fong, Jill; Gurwitsch, Edith D.; Kump, Lisa; Klein, Renata

doi:10.1097/00006250-199910000-00032

Cited by 10 publications

(20 citation statements)

References 3 publications

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“…Fetal red blood cells were still present in the final product, consistent with previous studies, 2 6 and so could be significant in cases of red cell antigen incompatibilities between the mother and fetus. Rh(D) incompatibilities, although clinically significant, are generally avoided by routine prophylactic anti-D treatment throughout the pregnancy.…”

Section: Discussionsupporting

confidence: 90%

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Contamination of salvaged maternal blood by amniotic fluid and fetal red cells during elective Caesarean section

Sullivan

Faulds

Ralph

2008

British Journal of Anaesthesia

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BackgroundCell salvage in obstetrics is still a controversial subject and has yet to be fully embraced. The aim of this exploratory study was to measure amniotic fluid (AF), heparin, and fetal red cell contamination of washed filtered salvaged maternal blood and to investigate differences based on the number of suction devices used.MethodsPatients undergoing elective Caesarean section were assigned alternately to one of two groups. In Group 1, all blood and AF was collected with one suction. In Group 2, AF was aspirated to waste with a second separate suction device before collection of any blood.ResultsIn both groups, alpha-fetoprotein (AFP), squames cells, and heparin were significantly reduced (P<0.001) by the washing and filtering process. Mean AFP levels post-filtration were 2.58 IU ml−1 in Group 1 and 3.53 IU ml−1 in Group 2. Squames cells were completely removed in all but two cases. Fetal red blood cells were still present in the final product, range 0.13–4.35%. In Group 1, haemoglobin and haematocrit were higher than in Group 2, with lower white blood cell, AFP, and fetal red cell counts.ConclusionsThis study adds to the growing body of evidence that there is little or no possibility for AF contamination to enter the re-infusion system when used in conjunction with a leucodepletion filter.

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Section: Discussionsupporting

confidence: 90%

“…AFP was significantly reduced post-wash to levels well within the normal range for the general population, confirming the results from previous studies. 1 5 6 …”

Section: Discussionmentioning

confidence: 99%

Contamination of salvaged maternal blood by amniotic fluid and fetal red cells during elective Caesarean section

Sullivan

Faulds

Ralph

2008

British Journal of Anaesthesia

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“…They recommend clinicians inform the transfusion laboratory if cell salvage has been used to guide appropriate dosage. [44][45][46]…”

Section: "Weak D Positive" (D U -Positive)mentioning

confidence: 99%

Prevention of RhD Alloimmunization: A Comparison of Four National Guidelines

et al. 2017

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“…Recent data from the obstetrical literature suggest that intraoperative cell salvage is safe at the time of cesarean section through the cell washing and filtration process 30 . Similarly, oncological studies show a dramatic reduction in cancer cells after cell‐saver processing, with those remaining cells being nonviable.…”

Section: Preoperative Techniquesmentioning

confidence: 99%