Clearance of inhaled technetium-99m-DTPA as a clinical index of pulmonary vascular disease in systemic sclerosis

Kon, OM; Daniil, Zoe; Black, CM; Bois, RM du

doi:10.1183/09031936.99.13113399

Cited by 14 publications

(8 citation statements)

References 18 publications

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“…Studies in humans with acute respiratory distress syndrome showed that the lung clearance correlated with the severity of the hypoxia and parenchymal lesions [6]. In patients with progressive systemic sclerosis, lung clearance was higher in fibrosing alveolitis than in pulmonary vascular disease alone, but both were increased compared to normal controls [7].…”

Section: Discussionmentioning

confidence: 99%

“…A possible way to measure the alveolar capillary membrane permeability is by radionuclide aerosol lung imaging. The rate of the clearance of the aerosol is inversely related to the integrity of the alveolar capillary barrier [5][6][7]. In smokers and in patients with fibrotic lung disease this integrity is disrupted causing an increased clearance of the radionuclide aerosol [8,9].…”

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confidence: 99%

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Pertechnegas lung clearance in different forms of interstitial lung disease

Thomeer

Dehaes²,

Mortelmans³

et al. 2002

Eur Respir J

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Interstitial lung diseases (ILD) are characterized by an acute or chronic inflammation of the alveolar capillary membrane, which affects the permeability of this membrane. A possible way to measure the permeability of the membrane is by radionuclide aerosol imaging. Pertechnegas, a gas composed of technetium-labelled carbon particles, has recently been proposed as a new ventilation agent to measure this lung clearance.The clearance by pertechnegas in the four most common forms of ILD (eight patients with connective tissue disease, 10 with hypersensitivity pneumonitis, nine with idiopathic interstitial pneumonia and 10 with sarcoidosis) was measured and compared with 10 nonactive smoking controls. Because forced vital capacity (FVC), total lung capacity (TLC) and carbon monoxide diffusing capacity of the lung (DL,CO) are used in the assessment of functional severity of the ILD, the pertechnegas clearance was correlated with these lung-function indices.It was found that the time to half clearance of pertechnegas of the lung is significantly decreased in idiopathic interstitial pneumonia (pv0.0001), hypersensitivity pneumonitis (p=0.0005) and connective tissue disease (p=0.002) but not in sarcoidosis when compared with 10 nonsmoking controls. A significant correlation is also found between time to half clearance and FVC (r=0.76; pv0.0001), TLC (r=0.63; pv0.0001) and DL,CO (r=0.75; pv0.0001) for all groups together. For all subjects as a group, the time to half clearance is shorter in the upper lung zones than in the lower zones (pv0.0001) and the ratio between both zones is not significantly different between the different types of disease.These results indicate that pertechnegas clearance is increased in idiopathic interstitial pneumonia, hypersensitivity pneumonitis and connective tissue disease, but not in sarcoidosis and is related to the functional severity of the disease.

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Pertechnegas lung clearance in different forms of interstitial lung disease

Thomeer

Dehaes²,

Mortelmans³

et al. 2002

Eur Respir J

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“…Alveolar clearance is an index of epithelial permeability and has been used as a marker of alveolar inflammation in a number of pulmonary pathologies (17,18,19). In our experience, in non-smoking patients, alveolar clearance may be a further tool in identifying patients with a higher probability of presenting an active alveolitis.…”

Section: Discussionmentioning

confidence: 81%

Bronchoalveolar lavage in systemic sclerosis with lung involvement: role and correlations with functional, radiological and scintigraphic parameters

et al. 2010

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Objectives: To evaluate the role and the prognostic value of bronchoalveolar lavage (BAL) in scleroderma patients with interstitial lung disease. Methods:We reviewed the records of 79 patients with Systemic Sclerosis (SSc) who had dyspnea and pulmonary involvement and underwent BAL study. Sixty-two patients were prospectively followed-up for 12-36 months and reevaluated by pulmonary function tests (PFTs).Results: 79 SSc patients were enrolled (71 F and 8 M), 55 with limited and 24 with a diffuse form; mean age 55 ± 13 years; mean disease duration 55.2 ± 59 months. All patients were ANA positive, of these 30 were

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“…The halftime of clearance was estimated in minutes for each lung and the average value was obtained. A clearance half-time of <40 min was regarded as abnormal and a clearance half-time of less than 20 min [50% of normal] was categorized as very rapid [5,14,15].…”

Section: Hrct In Sarcoidosis Patientsmentioning

confidence: 99%

Clearance of technetium-99m-DTPA in pulmonary sarcoidosis

Αντωνίου

Tzanakis

Malagari

et al. 2016

Monaldi Arch Chest Dis

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Background. The aim of this study was to explore the possible association of the lung clearance of 99mTc- DTPA scan with HRCT lung abnormalities and with the pulmonary function tests [PFTs] in patients with sarcoidosis. Methods. We studied prospectively 15 patients [5 males, 10 females] of median age 46yr [range 27-67] with histologically proved sarcoidosis. HRCT scoring included the sum of the severity and extent of lymph node enlargement and parenchymal involvement. Results. The mean DTPA clearance half-time [τ 1/2 <40 min] was found [mean [SD]] 38.3+4.5min. The lymph node enlargement was found 34% and the parenchymal involvement 12%. DTPA clearance was negatively correlated with the parenchymal involvement [r= -0.651, p=0.009]. The HRCT parenchymal abnormalities were found significantly correlated with PFTs [FVC [r= -0.65, p=0.008] and TLCO [r= -0.76, p=0.02]. Conclusions. Our data suggest a moderate association between 99mTc-DTPA scan and HRCT in pulmonary sarcoidosis. However, further studies in large scale of sarcoid patients are needed to clarify the role of this novel methodology in the evaluation and follow-up of this disorder.

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Clearance of inhaled technetium-99m-DTPA as a clinical index of pulmonary vascular disease in systemic sclerosis

Cited by 14 publications

References 18 publications

Pertechnegas lung clearance in different forms of interstitial lung disease

Pertechnegas lung clearance in different forms of interstitial lung disease

Bronchoalveolar lavage in systemic sclerosis with lung involvement: role and correlations with functional, radiological and scintigraphic parameters

Clearance of technetium-99m-DTPA in pulmonary sarcoidosis

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