Clearance of intracellular bacterial infections by hyaluronic acid-based ROS responsive drug delivery micelles

Qiu, Yuanhao; Shang, Kun; Xu, Ningning; Chen, Peng; Gao, Huashan; Mu, Haibo; Wei, Feng; Duan, Jinyou

doi:10.1016/j.ijbiomac.2023.125506

Cited by 4 publications

(2 citation statements)

References 41 publications

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“…13 Saccharides and their polymers, renowned for their ubiquitous availability and biocompatibility, often play a fundamental role in targeted drug delivery systems. 14 N-Acetylglucosamine, 15 mannose, 16 sialic acid, 17 and hyaluronic acid 18,19 can be modified or incorporated into polymers to specifically bind to receptors such as galectins, mannosebinding lectins, siglecs, and CD44, respectively, offering promising targeted therapeutic approaches. However, most of these compounds have restricted efficacy, hindering their broader use in biomedical application.…”

Section: Introductionmentioning

confidence: 99%

“…Saccharides and their polymers, renowned for their ubiquitous availability and biocompatibility, often play a fundamental role in targeted drug delivery systems . N-Acetylglucosamine, mannose, sialic acid, and hyaluronic acid , can be modified or incorporated into polymers to specifically bind to receptors such as galectins, mannose-binding lectins, siglecs, and CD44, respectively, offering promising targeted therapeutic approaches. However, most of these compounds have restricted efficacy, hindering their broader use in biomedical application. , Inspired by natural polysaccharides, glycopolymers, a class of polymers with sugar pendants attached to the backbone, were designed and prepared to mimic the interaction between carbohydrate polymers and lectins (known as carbohydrate-binding proteins for receptors on the cell membrane). ,− Mannose-based polymers are frequently utilized in studies on RAW264.7 macrophage endocytosis , and galactose-containing polymers exhibit enhanced intracellular uptake by HepG2 cells in vitro as compared to L929 and MCF-7 cells .…”

Section: Introductionmentioning

confidence: 99%

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Enhancing Targeted Photodynamic Therapy: Star-Shaped Glycopolymeric Photosensitizers for Improved Selectivity and Efficacy

Lin,

Ma,

Zuo

et al. 2024

Biomacromolecules

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Targeted photodynamic therapy (PDT) offers advantages over nontargeted approaches, including improved selectivity, efficacy, and reduced side effects. This study developed star-shaped glycopolymeric photosensitizers using porphyrin-based initiators via ATRP. Incorporating a porphyrin core gave the polymers fluorescence and ROS generation, while adding fructose improved solubility and targeting capabilities. The photosensitizers had high light absorption, singlet oxygen production, specificity, low dark toxicity, and biocompatibility. The glycopolymers with longer sugar arms and higher density showed better uptake on MCF-7 and MDA-MB-468 cells compared to HeLa cells, indicating enhanced targeting capabilities. Inhibition of endocytosis confirmed the importance of the GLUT5 receptor. The resulting polymers exhibited good cytocompatibility under dark conditions and satisfactory PDT under light irradiation. Interestingly, the polymers containing fructose have a GLUT5-dependent elimination effect on the MCF-7 and MDA-MB-468 cells. The intracellular ROS production followed a similar pattern, indicating that the fructose polymer exhibits specific targeting toward cells with GLUT5 receptors.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Enhancing Targeted Photodynamic Therapy: Star-Shaped Glycopolymeric Photosensitizers for Improved Selectivity and Efficacy

Lin,

Ma,

Zuo

et al. 2024

Biomacromolecules

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Hyaluronic Acid Receptor‐Mediated Nanomedicines and Targeted Therapy

Ouyang,

Zhao,

et al. 2024

Small Methods

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Hyaluronic acid (HA) is a naturally occurring polysaccharide found in the extracellular matrix with broad applications in disease treatment. HA possesses good biocompatibility, biodegradability, and the ability to interact with various cell surface receptors. Its wide range of molecular weights and modifiable chemical groups make it an effective drug carrier for drug delivery. Additionally, the overexpression of specific receptors for HA on cell surfaces in many disease states enhances the accumulation of drugs at pathological sites through receptor binding. In this review, the modification of HA with drugs, major receptor proteins, and the latest advances in receptor‐targeted nano drug delivery systems (DDS) for the treatment of tumors and inflammatory diseases are summarized. Furthermore, the functions of HA with varying molecular weights of HA in vivo and the selection of drug delivery methods for different diseases are discussed.

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ROS sensitive micelles of carbon dioxide based amphiphilic polymer for delivery of avermectin

Qiu,

Zhao,

Niu

et al. 2024

European Polymer Journal

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Clearance of intracellular bacterial infections by hyaluronic acid-based ROS responsive drug delivery micelles

Cited by 4 publications

References 41 publications

Enhancing Targeted Photodynamic Therapy: Star-Shaped Glycopolymeric Photosensitizers for Improved Selectivity and Efficacy

Enhancing Targeted Photodynamic Therapy: Star-Shaped Glycopolymeric Photosensitizers for Improved Selectivity and Efficacy

Hyaluronic Acid Receptor‐Mediated Nanomedicines and Targeted Therapy

ROS sensitive micelles of carbon dioxide based amphiphilic polymer for delivery of avermectin

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